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NFL Week 10 Odds – Opening Betting Lines & Spreads for All Games

John Perrotto

by John Perrotto in NFL Football

Updated Nov 6, 2022 · 5:11 PM PST

Nov 6, 2022; Landover, Maryland, USA; Minnesota Vikings quarterback Kirk Cousins (8) walks off the field against the Washington Commanders during the second half at FedExField. Mandatory Credit: Brad Mills-USA TODAY Sports
  • The Panthers are 2.5-road favorites over the Falcons on Thursday Night Football to open NFL Week 10
  • The unbeaten Eagles are the biggest opening favorites at 10.5 points over the visiting Commanders
  • A look at all the opening NFL Week 10 odds can be found below with early predictions

Week 10 of the NFL season begins Thursday night when the Atlanta Falcons visit the Carolina Panthers in an NFC South matchup.

The Falcons (4-5) have opened as 2.5-point favorites despite losing to the Los Angeles Chargers 20-17 at home Sunday. The Panthers (2-7) got handled by the Bengals 42-21 in Cincinnati.

Sunday Night Football will feature the San Francisco 49ers (4-4) hosting the Chargers (5-3). The Washington Commanders (4-5) play the Eagles (8-0) in Philadelphia on Monday Night Football.

The NFL odds will be updated throughout the week.

NFL Week 10 Opening Odds

Team Moneyline Spread Over/Under
Atlanta Falcons -132 -2.5 (-110) Over 41.5 (-110)
Carolina Panthers +112 +2.5 (-110) Under 41.5 (-110)
Team Moneyline Spread Over/Under
Seattle Seahawks -102 +1 (-110) Over 44.5 (-110)
Tampa Bay Buccaneers -116 -1 (-110) Under 44.5 (-110)
Team Moneyline Spread Over/Under
Jacksonville Jaguars +350 +10 (-110) Over 49.5 (-110)
Kansas City Chiefs -450 -10 (-110) Under 49.5 (-110)
Team Moneyline Spread Over/Under
Houston Texans +210 +6 (-110) Over 38.5 (-115)
New York Giants -255 -6 (-110) Under 38.5 (-105)
Team Moneyline Spread Over/Under
New Orleans Saints -148 -3 (-106) Over 41.5 (-115)
Pittsburgh Steelers +126 +3 (-114) Under 41.5 (-105)
Team Moneyline Spread Over/Under
Detroit Lions +116 +2.5 (-110) Over 47.5 (-110)
Chicago Bears -136 -2.5 (-110) Under 47.5 (-110)
Team Moneyline Spread Over/Under
Cleveland Browns +176 +4 (-110) Over 48 (-110)
Miami Dolphins -210 -4 (-110) Under 48 (-110)
Team Moneyline Spread Over/Under
Minnesota Vikings +290 +7.5 (-110) Over 48.5 (-110)
Buffalo Bills -360 -7.5 (-110) Under 48.5 (-110)
Team Moneyline Spread Over/Under
Denver Broncos +114 +2 (-110) Over 39.5 (-110)
Tennessee Titans -134 -2 (-110) Under 39.5 (-110)
Team Moneyline Spread Over/Under
Indianapolis Colts +164 +4 (-110) Over 42 (-110)
Las Vegas Raiders -196 -4 (-110) Under 42 (-110)
Team Moneyline Spread Over/Under
Arizona Cardinals +158 +3.5 (-110) Over 43.5 (-110)
Los Angeles Rams -188 -3.5 (-110) Under 43.5 (-110)
Team Moneyline Spread Over/Under
Dallas Cowboys -215 -4.5 (-110) Over 43.5 (-110)
Green Bay Packers +180 +4.5 (-110) Under 43.5 (-110)
Team Moneyline Spread Over/Under
Los Angeles Chargers +210 +6 (-110) Over 47.5 (-110)
San Francisco 49ers -255 -6 (-110) Under 47.5 (-110)
Team Moneyline Spread Over/Under
Washington Commanders +400 +10.5 (-110) Over 44.5 (-110)
Philadelphia Eagles -520 -10.5 (-110) Under 44.5 (-110)

Odds as of November 6th at FanDuel Sportsbook.

The Eagles, the last unbeaten team in the NFL, are the biggest Week 10 favorites at 10.5 points over the Commanders. The smallest line is the one point in which the Tampa Bay Buccaneers are favored over the Seattle Seahawks in a game that will be played in Munich, Germany.


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The Jacksonville Jaguars-Kansas City Chiefs matchup has the largest over/under at 49.5 points. The lowest total is 38.5 points for the Houston Texans-New York Giants game.

Vikings vs Bills Early Odds & Prediction

The Bills have opened as 7.5-point home favorites over the Vikings for next Sunday afternoon’s game in Orchard Park, N.Y. Minnesota will enter on a six-game winning streak.

Kirk Cousins threw two touchdowns passes Sunday to lead the Vikings (7-1) to a 20-17 road victory over the Washington Commanders. He completed 22 of 40 attempts for 265 yards.

The Vikings’ Harrison Smith had an interception midway through the fourth quarter to set up the tying touchdown. Greg Joseph won it with a 28-yard field goal with 12 seconds left.

The Bills (6-2) were on the wrong of a 20-17 score against the New York Jets at East Rutherford, ending Buffalo’s four-game winning streak.

Josh Allen ran for two touchdowns, but the Jets defense limited him to 18-of-34 passing for 205 yards. New York also picked Allen off twice while holding him with a TD pass.

The Vikings have the better record, but the Bills have the most talented team in the league. Thus, the spread seems a little low and one Buffalo should cover with a bounce back performance.

Pick: Bills -7.5 (-110)

Cowboys vs Packers Early Odds & Prediction

Despite being on the road, the Cowboys have been established as four-point picks over the Packers in the Sunday late-afternoon window.

The Cowboys (6-2) were off this weekend after winning their previous two games. Dallas defeated the visiting Chicago Bears 49-29 in Week 8.

The Packers (3-6) lost their fifth straight game with an ugly 15-6 defeat against the Lions in Detroit. Aaron Rodgers threw three interceptions to tie a career-worst and his incompletion on fourth down from the Detroit 17 in the last minute ended the Packers’ hopes of winning.

Rodgers finished 23 of 42 for 291 yards and a touchdown. The five-game losing streak is the Packers’ longest since 2008, Rodgers’ first season as their starter.

The Packers are reeling but the Cowboys could be rusty coming off their bye. Surely, Rodgers can rally Green Bay to a good performance at home.

Pick: Packers +4 (-110)

Chargers vs 49ers Early Odds & Prediction

Coming off a bye this week, the 49ers are six-point home favorites over the Chargers on SNF at Santa Clara, Calif. San Francisco got back to .500 by beating the Los Angeles Rams 31-14 on the road in Week 8.

Cameron Dicker’s 37-yard field goal as time expired gave the Chargers their road victory Sunday over the Falcons. Dicker was signed as a free agent three days earlier to take the place of the injured Dustin Hopkins.

Justin Herbert’s 22-yard pass to Joshua Palmer set up Dicker’s kick. Herbert was 30-of-43 passing for 245 yards with one touchdown and one interception.

The addition of running back Christian McCaffrey in a trade with the Carolina Panthers has boosted the 49ers’ offense. However, the Chargers are winners of four of their last five games and should at least keep it close.

Pick: Chargers +6 (-110)



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