- NFL Week 12 begins Thursday when the Bills visit the Lions in the traditional Thanksgiving Day game in Detroit
- The Chiefs are the biggest opening favorites by 14 points over the Rams
- A look at all the NFL Week 12 opening odds can be found below with early predictions
NFL Week 12 starts off Thursday with three Thanksgiving games, beginning with the Buffalo Bills visiting the Detroit Lions. The Bills have opened as 10-point favorites.
Also on the Turkey Day docket are the New York Giants at Dallas Cowboys and New England Patriots at Minnesota Vikings. The Cowboys are 7.5-point favorites, and the Vikings are three-point picks.
Sunday Night Football features the Philadelphia Eagles hosting the Green Bay Packers. The Pittsburgh Steelers visit the Indianapolis Colts on Monday Night Football. The Eagles are favored by 6.5 points and the Colts by three points.
The NFL odds will be updated throughout the week.
NFL Week 12 Opening Odds
|Buffalo Bills||-510||-10 (-110)||Over 52.5 (-110)|
|Detroit Lions||+390||+10 (-110)||Under 52.5 (-110)|
|New York Giants||+310||+7.5 (-106)||Over 43.5 (-110)|
|Dallas Cowboys||-390||-7.5 (-114)||Under 43.5 (-110)|
|New England Patriots||+144||+3 (-104)||Over 42.5 (-110)|
|Minnesota Vikings||-172||-3 (-118)||Under 42.5 (-110)|
|Baltimore Ravens||-205||-4 (-110)||Over 46.5 (-110)|
|Jacksonville Jaguars||+172||+4 (-110)||Under 46.5 (-110)|
|Denver Broncos||-146||-2.5 (-115)||Over 36.5 (-106)|
|Carolina Panthers||+124||+2.5 (-105)||Under 36.5 (-114)|
|Atlanta Falcons||+148||+3 (-104)||Over 42.5 (-114)|
|Washington Commanders||-176||-3 (-118)||Under 42.5 (-106)|
|Tampa Bay Buccaneers||-172||-3 (-118)||Over 44.5 (-106)|
|Cleveland Browns||+144||+3 (-104)||Under 44.5 (-114)|
|Cincinnati Bengals||-126||-1.5 (-110)||Over 42.5 (-114)|
|Tennessee Titans||+108||+1.5 (-110)||Under 42.5 (-106)|
|Houston Texans||+440||+11.5 (-110)||Over 45.5 (-110)|
|Miami Dolphins||-590||-11.5 (-110)||Under 45.5 (-110)|
|Chicago Bears||+154||+3.5 (-105)||Over 44.5 (-110)|
|New York Jets||-184||-3.5 (-115)||Under 44.5 (-110)|
|Las Vegas Raiders||+158||+3.5 (-110)||Over 47.5 (-110)|
|Seattle Seahawks||-188||-3.5 (-110)||Under 47.5 (-110)|
|Los Angeles Chargers||-158||-3 (-105)||Over 48 (-110)|
|Arizona Cardinals||+134||+3 (-115)||Under 48 (-110)|
|Los Angeles Rams||+640||+14 (-110)||Over 44 (-110)|
|Kansas City Chiefs||-950||-14 (-110)||Under 44 (-110|
|New Orleans Saints||+340||+8.5 (-110)||Over 42 (-110)|
|San Francisco 49ers||-430||-8.5 (-110)||Under 42 (-110)|
|Green Bay Packers||+260||+6.5 (-105)||Over 45.5 (-110)|
|Philadelphia Eagles||-320||-6.5 (-115)||Under 45.5 (-110)|
|Pittsburgh Steelers||+126||+3 (-118)||Over 39.5 (-110)|
|Indianapolis Colts||-148||-3 (-104)||Under 39.5 (-110)|
Odds as of November 20th at FanDuel Sportsbook.
The Kansas City Chiefs are the biggest favorites on the board at 14 points over the Los Angeles Rams. The Cincinnati Bengals are the slimmest choices by 1.5 points against the Tennessee Titans.
Bills vs Lions has the largest over/under at 52.5 points. The lowest total is 36.5 points for the Denver Broncos-Carolina Panthers game.
Patriots vs Vikings Early Odds & Prediction
The Patriots (6-4) will take a three-game winning streak into their Thanksgiving Night matchup with the Vikings in Minneapolis. The Vikings (8-2) had their seven-game winning streak end in a big way Sunday as they were routed 40-3 by the visiting Dallas Cowboys.
The Patriots stunned the Jets 10-3 as rookie Marcus Jones returned a punt 84 yards for a touchdown with five seconds remaining. It was the first punt return for a TD in the NFL this year.
— New England Patriots (@Patriots) November 20, 2022
Mac Jones completed 23 of 27 passes for 246 yards. However, the Patriots were 4 of 15 on third down and did not score an offensive touchdown.
The Vikings offense was stifled by the Cowboys as Kirk Cousins was 12-of-23 passing for 105 yards and Justin Jefferson was limited to three catches for 33 yards. A week earlier, Jefferson had a career-high 193 yards in a win over the Bills.
The Patriots aren’t very pretty but find ways to win. Look for them to tuck up the number.
Pick: Patriots +3 (-104)
Packers vs Eagles Early Odds & Prediction
The Eagles (9-1) bounced back from their first loss of the season by edging the Indianapolis Colts 17-16 on Sunday on the road. The Packers (4-7) are in desperation mode after losing six of their last seven games.
Jalen Hurts ran for an 8-yard touchdown with 1:20 left to give the Eagles the win. He completed 18 of 25 passes for 190 yards and rushed for 86 yards on 16 carries.
— Philadelphia Eagles (@Eagles) November 20, 2022
Philadelphia never led until Jake Elliott kicked the extra point following Hurts’ TD.
The Packers lost to the visiting Tennessee Titans 27-17 on Thursday Night Football.
Sunday Night Football gives the Eagles a national stage to show why they have the best record in the league. Look for them to win handily.
Pick: Eagles -6.5 (-115)
Rams vs Chiefs Early Odds & Prediction
Though the Rams (3-7) are having a miserable season, it is still jarring to see a defending Super Bowl champion listed as two-touchdown underdogs against the Chiefs (7-2).
The Rams’ losing streak reached four games Sunday as they fell 27-20 to the Saints in New Orleans. The Rams led 14-10 at halftime but could not hold on after quarterback Matthew Stafford left the game in the third quarter and was placed in concussion protocol.
The Chiefs (7-2) had won three in a row going into their road game against the Los Angeles Chargers on Sunday Night Football. Still, look for the Rams to show some pride and lose by less than two touchdowns.
Pick: Rams +14 (-110)
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