NFL Week 16 Odds – Opening Betting Lines & Spreads for All Games
- NFL Week 16 begins with the Jaguars visiting the Jets on Thursday Night Football
- The Chiefs are the week’s biggest opening favorites at 10 points over the Seahawks
- All the NFL Week 16 opening odds can be found below with early predictions
NFL Week 16 kicks off with the Jacksonville Jaguars visiting the New York Jets on Thursday Night Football.
The Jaguars (6-8) are favored by 1.5 points after beating the Dallas Cowboys 40-34 in overtime Sunday. The Jets (7-7) lost to the Detroit Lions 20-137
With Christmas falling on Sunday, the bulk of the NFL Week 16 schedule will be played Saturday. In a Christmas Eve game on Saturday night, the Pittsburgh Steelers host the Las Vegas Raiders and are 1.5-point favorites.
Three games will be played on Sunday. The Green Bay Packers visit the Miami Dolphins as 4.5-point underdogs, the Los Angeles Rams host the Denver Broncos as one-point dogs, and the Tampa Bay Buccaneers play at the Arizona Cardinals as a four-point pick.
Monday Night Football features the Indianapolis Colts playing at home against the Los Angeles Chargers, who are favored by three points.
The NFL odds will be updated throughout the week.
NFL Week 16 Opening Odds
| Team | Moneyline | Spread | Over/Under |
|---|---|---|---|
| Jacksonville Jaguars | -110 | -1.5 (-102) | Over 41.5 (-110) |
| New York Jets | -106 | +1.5 (-120) | Under 41.5 (-110) |
| Team | Moneyline | Spread | Over/Under |
| New York Giants | +168 | +4 (-110) | Over 47.5 (-110) |
| Minnesota Vikings | -200 | -4 (-110) | Under 47.5 (-110) |
| Team | Moneyline | Spread | Over/Under |
| New Orleans Saints | +132 | +3 (-115) | Over 35.5 (-110) |
| Cleveland Browns | -156 | -3 (-105) | Under 35.5 (-110) |
| Team | Moneyline | Spread | Over/Under |
| Detroit Lions | -148 | -3 (-106) | Over 44.5 (-110) |
| Carolina Panthers | +126 | +3 (-114) | Under 44.5 (-110) |
| Team | Moneyline | Spread | Over/Under |
| Cincinnati Bengals | -166 | -3 (-112) | Over 41 (-110) |
| New England Patriots | +140 | +3 (-108) | Under 41 (-110) |
| Team | Moneyline | Spread | Over/Under |
| Buffalo Bills | -360 | -8 (-110) | Over 41 (-110) |
| Chicago Bears | +295 | +8 (-110) | Under 41 (-110) |
| Team | Moneyline | Spread | Over/Under |
| Houston Texans | +275 | +7 (-106) | Over 41 (-110) |
| Tennessee Titans | -340 | -7 (-114) | Under 41 (-110) |
| Team | Moneyline | Spread | Over/Under |
| Seattle Seahawks | +370 | +10 (-110) | Over 48.5 (-110) |
| Kansas City Chiefs | -480 | -10 (-110) | Under 48.5 (-110) |
| Team | Moneyline | Spread | Over/Under |
| Atlanta Falcons | +265 | +7 (-110) | Over 40.5 (-110) |
| Baltimore Ravens | -330 | -7 (-110) | Under 40.5 (-110) |
| Team | Moneyline | Spread | Over/Under |
| Washington Commanders | +285 | +7.5 (-114) | Over 40.5 (-110) |
| San Francisco 49ers | -355 | -7.5 (-106) | Under 40.5 (-110) |
| Team | Moneyline | Spread | Over/Under |
| Philadelphia Eagles | -112 | -1.5 (-105) | Over 51 (-110) |
| Dallas Cowboys | -104 | +1.5 (-115) | Under 51 (-110) |
| Team | Moneyline | Spread | Over/Under |
| Las Vegas Raiders | +102 | +1.5 (-110) | Over 40.5 (-110) |
| Pittsburgh Steelers | -120 | -1.5 (-110) | Under 40.5 (-110) |
| Team | Moneyline | Spread | Over/Under |
| Green Bay Packers | +168 | +4.5 (-114) | Over 46.5 (-110) |
| Miami Dolphins | -200 | -4.5 (-106) | Under 46.5 (-110) |
| Team | Moneyline | Spread | Over/Under |
| Denver Broncos | -108 | -1 (-105) | Over 35 (-110) |
| Los Angeles Rams | -108 | +1 (-115) | Under 35 (-110) |
| Team | Moneyline | Spread | Over/Under |
| Tampa Bay Buccaneers | -200 | -4 (-110) | Over 41 (-110) |
| Arizona Cardinals | +168 | +4 (-110) | Under 41 (-110) |
| Team | Moneyline | Spread | Over/Under |
| Los Angeles Chargers | -164 | -3 (-110) | Over 47.5 (-114) |
| Indianapolis Colts | +138 | +3 (-110) | Under 47.5 (-106) |
Odds as of December 18th at DraftKings Sportsbook.
The Kansas City Chiefs are the NFL Week 16’s biggest opening favorites by 10 points over the Seattle Seahawks. The Denver Broncos are the smallest favorites at one point over the Los Angeles Rams.
The largest over/under is 51 points for the Philadelphia Eagles-Dallas Cowboys game. Broncos vs Rams has the lowest total at 35 points.
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Eagles vs Cowboys Early Odds & Prediction
Some of the luster is off this matchup after the Philadelphia Eagles all but clinched the NFC East title Sunday with a combination of their 25-20 victory over the Chicago Bears and the Dallas Cowboys’ 40-34 loss in overtime to the Jacksonville Jaguars.
However, it should still be an interesting game after Jalen Hurts tied a career-high with three touchdown runs Sunday for the Eagles. His 13 rushing TDs are one short of the NFL single-season record for a quarterback set by Cam Newton in 2011 with the Carolina Panthers.
Hurts finished with 61 yards rushing. He also threw for 315 yards, completing 22 of 37 passes with two interceptions.
68 big ones#PHIvsCHI | #FlyEaglesFly pic.twitter.com/N2YUdm6fFm
— Philadelphia Eagles (@Eagles) December 18, 2022
The Cowboys couldn’t hold a 27-10 lead and wound up losing when the Jaguars’ Rayshawn Jenkins had a 52-yard interception return for a TD in overtime. That snapped Dallas’ five-game winning streak.
Cowboys quarterback Dak Prescott completed 23 of 30 passes for 256 yards, with three touchdowns and two interceptions. Two of his TD passes went to Noah Brown.
The Eagles have the best record in the NFL but the Cowboys need this game to try to get a good playoff seed.
Pick: Cowboys +1.5 (-115)
Bengals vs Patriots Early Odds & Prediction
The Cincinnati Bengals (10-4) will bring a six-game winning streak into this matchup after rallying for a 34-23 victory over the Tampa Bay Buccaneers on Sunday on the road. The Patriots (7-7) bizarrely lost to the Raiders 30-24 in Las Vegas for their third defeat in the four games.
Joe Burrow threw four touchdown passes in the second half as the Bengals overcame a 17-3 deficit at intermission. Cincinnati took over sole possessions of first place in the AFC Central by a game over the Baltimore Ravens.
Burrow finished 27 of 39 for 200 yards and was intercepted once.
First career TD for @wilcox_mitchell 👏#CINvsTB | 📺 CBS pic.twitter.com/tQHdyTAZR8
— Cincinnati Bengals (@Bengals) December 19, 2022
The Patriots lost when the Raiders’ Chandler Jones returned a botched lateral 48 yards for a touchdown on the game’s final play.
With the game tied 24-24, the Patriots tried a series of pitches to score a touchdown at the end of regulation. However, Jakobi Meyers heaved the ball across the field right into Jones’ arms and he scored untouched.
The Patriots’ backs are again the wall, so look for a strong bounce-back effort at home.
Pick: Patriots +3 (-108)
Jaguars vs Jets Early Odds & Prediction
Based solely on recency bias, it’s understandable why the Jaguars have opened as favorites. Jacksonville has won three of its last four games and the Jets have lost three games in a row and four of their last five.
However, the Jets still have a talented team – more so than the Jaguars — despite Zach Wilson’s disappointing play at quarterback. QB Mike White will likely return from rib injuries to play Thursday. If he does, then the Jets are a live dog.
Pick: Jets +1.5 (-120)
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John Perrotto has been covering and writing about sports for various outlets for over 40 years. His work has appeared in the likes of USA TODAY, ESPN.com, SI.com, Forbes.com, The Associated Press, Baseball Digest, and more. John is based out of Beaver Falls, PA.
