- Italian giant hosts Portuguese high-flyers in San Siro at 3:00 pm ET on Wednesday
- Porto is in the second spot at home with Inter Milan also second in Italy domestically
- See our Inter Milan vs Porto prediction, odds and best bets for the Champions League last 16
Two teams with shared Champions League history meet in Inter Milan vs Porto in the last 16 first leg in Italy on Wednesday with Inter favored in the Inter Milan vs Porto odds.
Both clubs were led to glory in the competition by superstar coach Jose Mourinho – Porto in 2004 and Inter Milan in 2010.
Now they meet at the San Siro with Porto in second place in the Portuguese league and Inter Milan in the same spot in Serie A, making it tough to pick our Inter Milan vs Porto prediction.
Porto won a tough qualifying group ahead of second-placed Club Brugge – after recovering from two straight opening defeats with a run of four successive wins.
Meanwhile, Inter Milan finished in second place in its group ahead of mighty Barcelona, winning at home and drawing away with the Spanish giants.
However, it was beaten home and away by Germany’s group winners Bayern Munich. See the odds and our Inter Milan vs Porto picks below.
Inter Milan vs Porto Odds
Inter Milan is a wide favorite for a second-leg win at -130 odds in the table above. Moreover, Porto is priced at +370 with the draw at +285. The game kicks off at 3:00 pm ET. Odds as of February 21 at DraftKings Sportsbook. Claim this DraftKings Sportsbook promo code before betting on the match to claim a unique sign-up bonus.
Over/Under & Spread for Inter Milan vs Porto
Porto is on a run of six straight wins in the Portuguese league.
But oddsmakers believe Inter Milan is more likely to be on target with a price of -310 to score at least twice (Team Total Over 1.5).
It could be more productive to back Inter Milan to score at least three goals at +100 (Team Total Over 2.5).
Meanwhile, Porto is rated at +240 to score only once or fail to hit the target (Team Total Under 1.5).
Among the spread offerings, Inter Milan is rated at +210 to win by two goals or more (Spread – 1.5).
For Porto, the odds for a win by one goal are an intriguing +330 (Spread -0.5).
Inter Milan is furthermore priced at -160 to advance to the next round. Porto is rated at +130. Both are considered longshots in the Champions League odds to win the title.
Inter Milan vs Porto Preview
Both these sides boast impressive defensive records ahead of this match.
Furthermore, Inter Milan has won 11 and lost just once in its last 12 competitive games.
It has won three times and drawn once in its last four Serie A games. But it sits 15 points behind leaders Napoli so the UCL is its only chance of winning a big honor this season.
The form of Porto is just as impressive as it has won its last 10 competitive games.
It is also unbeaten since late October with 19 wins and three draws during that spell ahead of Inter Milan vs Porto.
Therefore, it seems there could be a tight encounter in store at the San Siro with both teams full of confidence but also displaying an ability to get good results just now.
Inter was a 3-1 winner at home against Udinese last weekend, making it 12 wins from the last 13 games at its HQ.
Furthermore, Porto was a 1-0 home winner against Rio Ave last Saturday.
Lautaro Martinez to Score Odds
Argentine striker Lautaro Martinez has scored 13 goals in Serie A this season, with four of them coming in his last four appearances.
With one further UCL goal to his credit this season, he is the favorite to score in the Inter Milan vs Porto odds at +130.
Moreover, he is priced at +330 to score first or last.
— Inter (@Inter_en) February 20, 2023
His teammate Romelu Lukakau is the second favorite to score at +160. He has 11 Serie A goals and one UCL goal.
Iranian forward Mehdi Taremi of Porto has five UCL goals this season as well as 11 in the Portuguese league.
But he is only the fourth favorite to be on target in the Champions League picks at +275 – and at +750 to score first or last.
Inter Milan vs Porto History
These teams last met in 2005-16 with Porto winning 2-0 at home in the group stage and Inter claiming a 2-1 victory in the return meeting.
Inter Milan vs Porto Line-Ups & Injuries
Inter Milan potential line-up: Onana; Skriniar, Bastoni, Acerbi; Dumfries, Barella, Calhanoglu, Brozovic, Dimarco; Lukaku, Martinez
Inter Milan Injuries: Correa, Dalbert
Porto potential line-up: Costa; Mario, Pepe, Carmo, Sanusi; Franco, Eustaquio, Grujic, Pepe; Taremi, Namaso
Porto Injuries: Evanilson, Otavio
Inter Milan vs Porto Statistics
*Statistics from UCL Group Stage 2022-23.
Inter Milan vs Porto Prediction
Porto is surprisingly underrated by the oddsmakers ahead of this tie in the Inter Milan vs Porto odds.
They may trouble Inter Milan. And with five UCL goals this season – three in his last three appearances – Mehdi Teremi looks a good bet to score in our Inter Milan vs Porto prediction.
Inter Milan vs Porto Picks: Mehdi Taremi to Score +275