Lazio vs Napoli Odds & Prediction – Serie A Round 27

By Gary Gowers in Soccer News
Published:

- It’s Lazio vs Napoli in Serie A on Friday, February 27 at 2:45 pm ET
- Napoli is just two points and two places behind league leaders AC Milan
- We preview the game, look at the odds, and offer some picks below
It is Lazio vs Napoli as the two of Italy’s big names clash in round 27 of Serie A on Friday, February 27 at 2:45 pm ET at the Stadio Olimpico. Lazio is currently in sixth place, in the final European place, while Napoli is in the race for the title – just two places and two points behind leaders AC Milan.
We preview Lazio vs Napoli and offer below the best picks for this huge Serie A clash.
Lazio vs Napoli Odds
Matchup | Spread | Moneyline | Total |
---|---|---|---|
Lazio vs Napoli | LAZ -0.5 (-167) | NAP +0.5 (+138) | LAZ +195 | DRAW +245 | NAP +138 | Ov 2.5 (-113) | Un 2.5 (-110) |
Odds as of February 25 at Barstool Sportsbook.

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The bookies find this one tough to call but have made Napoli slight favorites at +138 in the Serie A odds with an implied win probability of 42%, while Lazio, at +195, has an implied 33.9% chance of a win. The Over 2.5 goals bet is pitched at -113, while under is also in negative money at -110, so, again, the bookies are unsure how this is going.
If you’re new to this sport and need advice on soccer betting’s pros and cons, there are plenty of directions you can go to betting this match and others.
Five Undefeated for Lazio in League
Lazio is currently sixth in Serie A, on the cusp of the European places, and comes into this game off the back of a run of five undefeated in the league and have kept clean sheets in their last two home games. In their last six Serie A games, they have picked up 11 points from the 18 available.
Let's stop war.#StopWar pic.twitter.com/T687rMUJdX
— Official SSC Napoli (@en_sscnapoli) February 24, 2022
In midweek, I Biancazzurri drew 2-2 at home to Porto but, as a result, crashed out of the Europa League 4-3 on aggregate, and also drew 1-1 in Serie A last Sunday with Udinese. The performance level against Udinese was a poor one and it took a Felipe Anderson equalizer on the stroke of halftime to earn them a point after falling behind as early as the fifth minute.
Sarri With Injury Problems
Coach Maurizio Sarri has a few injury problems to contend with, with Pedro (ankle), Ciro Immobile (influenza), Patryk Dziczek (heart condition), and Manuel Lazzari (hamstring) all unavailable for Sunday’s match.
📸 Morning training session 🏃♂️#UEL
💙 #ForzaNapoliSempre pic.twitter.com/moxAugCSAI
— Official SSC Napoli (@en_sscnapoli) February 23, 2022
Recent meetings between these two have been dominated by the Neapolitans who have won 11 of their last 14 head-to-heads in all competitions, including a 4-0 win in the reverse fixture in November and a 5-2 win last April.
Lazio vs Napoli Head-to-Head Stats
12-7-7 | Serie A record | 16-6-4 |
53 | Goals for | 47 |
40 | Goals against | 18 |
6th | Position in Serie A | 3rd |
L-D-W-D-L-D | Form guide (all competitions) | W-D-W-D-W-L |
Midweek Disappointment for Napoli
Napoli comes into this game off the back of a run of a seven-game run without defeat and has amassed a total of 14 points in Serie A from the last 18 available. They did however suffer disappointment in midweek when losing 4-2 at home to Barcelona; a result that saw them knocked out of the Europa League after drawing 1-1 in the Camp Nou.
⏹ | #LazioPorto 2-2
Triplice fischio all'Olimpico!#UEL#CMonEagles 🦅 pic.twitter.com/SHCwH7qC9D— S.S.Lazio (@OfficialSSLazio) February 24, 2022
Last weekend, they dropped crucial points in their quest for another Scudetto title when they drew 1-1 away at Cagliari although, in the end, were grateful for a point with Victor Osimhen equalizing with a header three minutes from time. A win would have taken them to the top of the table, so it was an opportunity missed but a point kept them in the title race.
Napoli With the Upper Hand
Luciano Spalletti, like Sarri, also has a few absentees to manage without, with Kévin Malcuit (calf), Lorenzo Insigne (muscle fatigue), Stanislav Lobotka (hamstring), André Zambo Anguissa (groin), and Hirving Lozano (shoulder) all unavailable for the trip to Rome.
🔥 Ultimo allenamento per la squadra prima di #LazioPorto!#UEL#CMonEagles 🦅 pic.twitter.com/rOExiGWRob
— S.S.Lazio (@OfficialSSLazio) February 23, 2022
Gli Azzurri will head into this with confidence off the back of their good form and fine record against Lazio, who will be hoping to use home advantage to tilt the odds back in their favor.
Lazio vs Napoli Picks
This is a tough one to call given that both teams have momentum and have similar records over the last six games, but Napoli’s incentive is huge given their proximity to the league leaders and having dropped two vital points last weekend. Therefore, with them still in plus money at +138, there is value in the away win.
Picks: Napoli to win (+138)
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Sports Writer
Once just a sports fanatic, fan-turned-writer Gary Gowers has been featured on European television and radio networks to discuss several professional football clubs. His work can be found in an assortment of publications like The Metro, MyFootballWriter.com, and BBC Radio Norfolk.