- A trio of midweek Eastern Conference MLS games is highlighted by the New York derby
- Inter Miami meets Nashville in a 2020 playoff rematch, while first-place New England visits Chicago
- Read on for a look at all the odds, along with betting previews and best bets
While some MLS observers will spend Wednesday looking towards that night’s Leagues Cup final between Club León and the Seattle Sounders, for six teams, there is the usual meat and potatoes of MLS regular-season games to whet the appetite.
MLS Odds – Sept 22
|Inter Miami vs Nashville SC||+195||+235||+145|
|New York Red Bulls vs New York City FC||+210||+280||+120|
|Chicago Fire vs New England Revolution||+215||+280||+120|
Odds as of September 21st at DraftKings
Inter Miami vs Nashville SC Prediction
This pair of 2020 expansion teams meet for just the sixth time in their short histories at 7:30 pm ET on Wednesday evening. Nashville won the teams’ first meeting last season on an Anibal Godoy goal, before a goalless draw was promptly followed by a memorable playoff meeting won 3-0 by Nashville.
The 2021 campaign witnessed Indiana Vassilev capping a 2-1 victory for Inter’s first win in the series back in August, a couple of months after the pair had again played out a nil-nil draw back in May.
Miami saw the club-record six-game unbeaten streak halted last Friday when the New York Red Bulls subjected it to a 4-0 thrashing, while Nashville had a five-game unbeaten run of its own upended with a 2-1 loss at Toronto.
— Nashville SC (@NashvilleSC) September 21, 2021
Nashville enters this game second in the Eastern Conference, with its three losses the fewest in the entire MLS. While it packs a potent one-two punch in Hany Mukhtar and CJ Sapong – making Nashville one of just two teams with two 10-goal scorers – the team’s real strength has been defense. No one has done more in that department than goalkeeper Joe Willis, who leads the league in shutouts with a career-high 10. He also has the lowest goals-against average of any goalie in the Eastern Conference with 0.96.
Best bet: Draw (+235)
New York Red Bulls vs New York City FC Prediction
Wednesday’s match is the first leg of a home-and-home series between these two city rivals, with both coming off long-awaited victories last weekend.
The Red Bulls ended a four-game winless run with their 4-0 win over Miami, which featured two goals from Fabio and was also just their second win since early July. That run of futility has seen the club slip from postseason contention, with the team now nine points off a playoff spot.
— Major League Soccer (@MLS) September 18, 2021
NYCFC meanwhile came from behind to register a 2-1 win over FC Cincinnati, with Valentin Castellanos converting a penalty for his 12th goal of the year to win the game. Castellanos will be hoping to continue his recent form against the Red Bulls, having scored a hat trick against them in the team’s 5-2 home victory over its rival last season, New York City’s largest victory in the history of the rivalry.
— Major League Soccer (@MLS) September 19, 2021
The Red Bulls won their home game against Citizens last year on a close 1-0 decision, one of 10 victories that the Red Bulls have clinched in the 18-game history of the rivalry, with two of those games ending in draws.
But while the Red Bulls have struggled this season, NYC is in a rich vein of form. The team is third in the conference, three points back of Nashville, and with 43 goals on the year is the second-highest-scoring team in the league, behind only New England’s 48.
Best bet: Draw (+280)
Chicago Fire vs New England Revolution Prediction
A playoff spot and a franchise-record win total will be New England’s reward if the Revs can grab a victory in Chicago on Wednesday. In addition, the team would also tie the team mark for most points in a season as well, with the Revs currently riding high in the race for the Supporters’ Shield, 10 points clear of second-placed Kansas City.
Seven points separating 3️⃣-🔟?
— Major League Soccer (@MLS) September 20, 2021
Though New England was held 1-1 by the Columbus Crew last weekend, it wasn’t for lack of trying. The Revs tied the all-time MLS single-game record with 33 shots on the day, with free-scoring forward Adam Buksa uncorking 11 of those. The Polish international also scored the team’s only goal, scoring his 11th of the season in the process.
Immediate response from the #NERevs!
The Crew gift-wrap one for Adam Buksa. 1-1. pic.twitter.com/76MaXmvZqh
— Major League Soccer (@MLS) September 19, 2021
The Revs, who drew in Chicago in the last meeting between the sides earlier this season and are unbeaten in the last four in the series, are 7-3-3 on the road this season, tying the Seattle Sounders for most road victories in MLS. Chicago meanwhile has a 5-4-4 home record at Soldier Field, and fell 2-0 to Montreal last Sunday for its fourth shutout loss in its past five games.
Best bet: New England (+120)