NFL Week 16 Odds – Opening Lines and Spreads for All Games

• NFL Week 16 opens Thursday night with the 49ers visiting the Titans
• The Buccaneers are the week’s biggest favorites at 13 points on the road over the Panthers
• A look at all the Week 16 opening odds and lines can be found below

Week 16 of the NFL season begins Thursday night when the Tennessee Titans host the San Francisco 49ers.

The 49ers (8-6) opened as 2.5-point favorites after being the Atlanta Falcons 31-13 on Sunday at home for their fifth win in six games. The AFC South-leading Titans (9-5) lost for the third time in four games, 19-13 to the Steelers in Pittsburgh.

Two Christmas games will be played Saturday with the Green Bay Packers (11-3) hosting the Cleveland Browns (7-6) and the Indianapolis Colts (8-6) visiting the Arizona Cardinals (10-4) in primetime. The Packers are favored by seven points and the Cardinals are three-point choices.

Sunday Night Football features the Dallas Cowboys (10-4) playing at home against the Washington Football Team (6-7) as 9.5-point picks. And the Miami Dolphins (7-7) travel to the New Orleans Saints (6-7) for Monday Night Football as three-point underdogs.

Here is look at the Week 16 opening lines:

NFL Week 16 Opening Odds

Odds as of December 19th at FanDuel.

Buccaneers Big Favorites Over Falcons

The Tampa Bay Buccaneers (10-3) are the week’s biggest favorites despite being on the road as they are 13-point picks over the Carolina Panthers (5-9).

Tampa Bay took a four-game winning streak into Sunday night’s game against the Saints in New Orleans. While the Panthers saw their losing streak reach four games by falling 31-14 to the Bills in Buffalo earlier in the day.

It seemed clear it wouldn’t be the Panthers’ day when kicker Zane Gonzalez injured his quadriceps a little more than hour before the game during warmups. He had to be helped off the field and Carolina was left without a placekicker.

Panthers K Zane Gonzalez injured his quad in warmups and miss the game.

This will be interesting…

(via @NFLonFox)pic.twitter.com/IoVPVk3X01

— B/R Gridiron (@brgridiron) December 19, 2021

Cam Newton lost his 12^th straight start for the Panthers, completing just 18 of 38 passes for 156 yards and one touchdown with one interception. But he did rush for 71 yards and a score on 15 carries.

Jaguars Slim Road Picks Over Jets

Despite having the worst record in the NFL, the Jacksonville Jaguars (2-12) are road favorites, albeit the slimmest on the board at one point, over the New York Jets (3-11).

The Jaguars lost their sixth straight game Sunday, dropping a 30-16 decision to the Houston Texans at home four days after coach Urban Meyer was fired.

Three and out, thanks to this 😤

📺 » @NFLonCBS pic.twitter.com/r4fu5dMz0m

— Houston Texans (@HoustonTexans) December 19, 2021

Jaguars rookie quarterback Trevor Lawrence did not show marked improvement in offensive coordinator Darrell Bevell’s first game as interim coach. In the game, the No. 1 overall pick in this year’s NFL Draft threw for 210 yards on 22-of-38 passing with no touchdowns or interceptions.

The Jets lost their third straight and for the six time in seven games as they blew an early 10-0 lead and fell 31-24 to the Dolphins in Miami.

Despite the loss, Brandin Echols had the biggest highlight for the Jets when he returned an interception 20 yards for a touchdown in the fourth quarter. Both Zach Wilson and Braxton Berrios rushed for scores.

FIRST PICK
FIRST PICK-SIX

LET'S GO @matayo_echols!!#NYJvsMIA on CBS pic.twitter.com/cGPCkIeRpo

— New York Jets (@nyjets) December 19, 2021

Unfortunately, Jets safety Elijah Riley was taken off the field on a backboard after being injured during the third quarter.

Highs and Lows

The week’s highest total is 49.5 points for the Los Angeles Rams’ visit to the Minnesota Vikings.

The Rams (9-4) entered the weekend fourth in the NFL in scoring average at 28.2 points a game. They visit the Seattle Seahawks on Tuesday night in a game postponed from Sunday because a COVID-19 outbreak with the Rams.

Los Angeles quarterback Matthew Stafford shined in the Rams’ 30-23 road victory over the Cardinals on Monday night.

Matthew Stafford vs Cardinals:

🐏 23/30
🐏 287 yards
🐏 3 TDs
🐏 139.2 passer rating pic.twitter.com/zpIKIdGK53

— PFF (@PFF) December 14, 2021

The Vikings (6-7) have a 26.5 scoring average going into their game against the Bears on Monday night in Chicago. That figure ranked 10^th in the league prior to Sunday.

Monday night’s game between the Dolphins and Saints total points is listed at 40.5. But the 31 points by the Dolphins against the Jets on Sunday was their second-highest total of the year. The Saints went into Sunday night’s game with the Buccaneers 11^th in the NFL in scoring defense with a 21.9 average.

Movement on the Line?

While the Titans are struggling, it still seems a bit of a surprise they are 2.5-point underdogs at home to the streaking 49ers. The Titans are winning their division after all, so look for the line to dip a little bit before Thursday.

The Saints being three-point picks at home over the Dolphins also seems like a light spread. While the Dolphins are on a six-game winning streak, only one of those victories have come over a team with a winning record — the Baltimore Ravens.