College Football Upset Predictions Week 4 – Top Underdog Picks Today

• Let’s go, Week 4 of the college football season is here and I’ve got the best underdog picks for today
• Can we trust Clemson with a two-touchdown spread? What’s Notre Dame’s mindset after a heartbreaking loss to Texas A&M?
• Check out my CFB upset predictions and picks for Week 4 in college football today

Fresh off a three out of four-performance last week with my CFB upset picks (thank you, Old Dominion), let’s talk upset potential in college football Sept. 20.

College football is more of an emotional game than the one played on Sundays, and we can use that in the early season to spot some teams that may be due for a letdown.

Here are my college football upset special predictions and picks for Week 4. All odds are as of Sept. 20.

CFB Upset Predictions: Syracuse +17.5 at Clemson

Last week we picked Georgia Tech to upset Clemson and we hit on it and now I am wondering if the Tigers have started to lose some faith in Dabo. The offense has not clicked and defensively, Georgia Tech did what it wanted for the most part.

Syracuse is 2-1, but the two wins came against patsies. Orange QB Steve Angeli (former Notre Dame back-up) leads the nation in passing yards at 1,072.

Clemson is 0-3 against the spread this season and has failed to cover the spread in its last six home games. I believe Syracuse will score some points and keep this one well within the spread.

• College Football Upset Picks: Syracuse +17.5 (-112 at DraftKings)

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CFB Upset Predictions: Purdue +24.5 at Notre Dame

This one might be my favorite one on the board today. Notre Dame is 0-2, and already, people are saying they’ve got no shot at the college football playoff, and the keyboard warriors want defensive coordinator Chris Ash out, already.

All that noise impacts college kids and I wonder about the Irish’s mindset coming in today. Purdue is 2-1 for new coach Barry Odom. They lost last week to USC 33-17, but did cover the 20.5 spread. This line opened at 27.5 and has dropped. Notre Dame destroyed Purdue last year 66-7.

Either Notre Dame obliterates Purdue or the Boilermakers hang around for a while and keep in close. I’m betting they keep it close. Notre Dame’s defense has some issues.

• College Football Upset Picks: Purdue (+24.5)

CFB Upset Predictions: Troy +5.5 at Buffalo

Remember Troy battled Clemson close, before losing by 11 in their second game of the season. I just don’t think Buffalo is that good. The Bulls were 23.5 point favorites over Kent State and hung on to win by three last week.

Troy lost starting QB Goose Crowder (great, great football name) against Memphis last week and now has had a week to get back-ups Tucker Kilcrease and Ui (short for Uiolevanuseaulaoleolo, yes, really) Ale ready. Troy has 16 defensive touchdowns since 2020, third most of any team in the nation.

I’m just not sold on Buffalo and think they’ll struggle against a good Troy defense.

• CFB Upset Pick: Troy +5.5 (-110 at Bet365)

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CFB Upset Predictions: Stanford +16.5 at Virginia

Virginia put up a whopping 700 yards in a win over William & Mary last week, but the Cavaliers step up in class today.

Stanford showed some major growth in a win over Boston College last week. Running back Micah Ford is a name to remember. He had 157 yards for the Cardinal.

Stanford has lost its last seven road games and the favorite has covered the spread in the last six Virginia games, but I like the Cardinal to slow down Virginia QB Chandler Morris and play well.

• CFB Upset Picks: Stanford +16.5 (-105 at FanDuel)