Alabama vs Missouri Odds, Spread & Early Prediction – CFB Week 7

• Missouri faces their toughest test against Alabama in CFB Week 7
• The Tigers look to stay undefeated on the season after facing the Crimson Tide
• See our Alabama vs Missouri odds, spread and early predictions

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No. 14 Missouri returns from a bye week to face No. 8 Alabama in College Football Week 7. The Tigers get their first ranked matchup of the season with extra preparation, while the Crimson Tide come in battle-tested after a grueling stretch. Alabama upset Georgia on the road 24-21, then followed it up by handling an improved Vanderbilt team 30-14, winning and covering in both games.

Since their season-opening loss to Florida State, the Tide have been rolling and look every bit like one of the nation’s top teams.

Can Missouri rise to the challenge and earn a signature win, or will Alabama’s talent prove too much? Let’s break it down with our Alabama vs. Missouri odds, spread, and early predictions.

Alabama vs Missouri Odds

Odds via DraftKings as of October 7 at 11 am ET. Bet on Alabama vs. Missouri at US betting sites.

Alabama vs Missouri Spread

The consensus line has Alabama as a 3-point road favorite with the total sitting at 51.5. The books haven’t been consistent with these odds, though. Originally, this matchup opened with the Tide as high as -5.5 and the total set at 55.5.

Given Missouri’s strong start and Alabama’s demanding schedule, it’s no surprise bettors have shown interest in the home underdog. For the Tigers, this is easily their biggest game of the season, but for Alabama, every week carries that weight after their opening loss to Florida State.

Crimson Tide vs Tigers Early Prediction

It’s tough to predict the tempo and scoring in this matchup, as both teams boast explosive offenses and elite defenses.

The Tigers are averaging 45.2 points per game, the second-most in the SEC. Defensively, they rank 2nd nationally in yards allowed per game (203.8), 1st in rushing yards allowed (62.4), and 10th in passing yards allowed (141.4).

Alabama has gone under the total in its last two games against Georgia and Vanderbilt, and has held three opponents to 14 points or fewer since its season-opening loss to Florida State. The Tide are allowing just 16.2 points per game, while Missouri is giving up only 14.6.

On offense, Alabama thrives through the air with Ty Simpson leading the way, but the ground game continues to lag. They rank 9th nationally in pass success rate but just 123rd in rush success rate. Missouri’s defense, meanwhile, sits 4th in pass success rate allowed and 39th against the run.

Are Missouri’s numbers as good as they appear, or are they a reflection of the weaker schedule they’ve faced so far?

We’ll find out here, along with how much Alabama’s run defense can hold up against sophomore Ahmad Hardy, who’s arguably been the best tailback in the country. He’s totaled 103 carries for 730 yards at 7.1 yards per rush with nine touchdowns. Alabama, meanwhile, gave up 227 rushing yards to Georgia a couple of weeks ago and then allowed 7.5 yards per carry to Vanderbilt last Saturday.

Ahmad Hardy leads the ENTIRE COUNTRY in rushing yards and touchdowns.

No other back in the country is within 100 yards of him.

If you don’t have him on your Heisman ballot you are not a serious person.

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— SEC Numbers Guy (@secnumbersguy) September 28, 2025

If that discrepancy carries over in Columbia, then the market moving the total toward the under and the spread toward Missouri makes sense.

Alabama vs Missouri Best Early Bet

I believe the Tigers can live up to the statistical standards we’ve seen so far. This is their biggest game in quite some time, and they have the pieces in place to either get the win or at least cover the number.

Mizzou has the best home winning percentage IN THE COUNTRY since 2023.

The Crimson Tide will become just the 2nd team to beat the Tigers at home if they can find a way to pull off a victory.

You simply don’t visit Faurot and leave with a win.

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— SEC Numbers Guy (@secnumbersguy) October 7, 2025

If the spread were below the key number of +3, or if Alabama weren’t in the middle of such a brutal stretch, this conversation might look different. But that’s not the case, which puts the Tide at a disadvantage and makes Missouri the more appealing side.

While the consensus spread is Missouri +3, some shops like FanDuel are offering +3.5 with -118 juice attached. I’ll pay a bit more to gain the hook on the points with the Tigers.

• Best Bet: Missouri +3.5 (-118)