Opening College Football Week 10 Odds, Spreads & Early Best Bets 2025

• The college football Week 10 odds have been posted at online sportsbooks
• The Week 10 slate is highlighted by #10 Vanderbilt vs #22 Texas, and #13 Oklahoma vs #17 Tennessee
• See the opening NCAAF Week 10 odds for all the power-conference and top-25 games

Six more top-25 teams lost on Saturday, throwing further chaos into an already muddled playoff picture. The college football Week 10 odds have been posted, including opening lines for the two ranked-vs-ranked games (#10 Vanderbilt vs #22 Texas, and #13 Oklahoma vs #17 Tennessee) and the two big rivalry games (Penn State vs Ohio State, and Georgia vs Florida).

The table below lists the opening college football Week 10 odds for all the power-conference and top-25 games. Under the table, find my favorite early lines to target in NCAAF Week 10.

College Football Week 10 Odds

More games will be added to the table as lines are released.

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The national championship odds ahead of Week 10 continue to favor undefeated #1 Ohio State (+200) with #2 Indiana a distant +600 second-favorite.

Early Week 10 Lines to Target: Vanderbilt (+1.5) vs Texas

The Commodores’ near-perfect season continued in Week 9 with an impressive 17-10 win at home over #15 Missouri. Vandy’s pass defense was suffocating, holding Matt Zollers to just 138 yards through the air on 14-of-23 passing.

Texas has rebounded from a disappointing 3-2 start with three straight wins, including a 23-6 home victory over then-#6 Oklahoma. But the last two wins have been anything but inspiring; the Longhorns eked out a 16-13 OT win at Kentucky in Week 8 as 13.5-point favorites, and needed overtime again in a 45-38 win at Mississippi State in Week 9 as 8.5-point chalk.

Making matters worse, starting QB Arch Manning left their Week 9 win with a concussion. Backup Matt Caldwell, a Troy transfer and former DII pivot, has thrown just 11 passes this season, though that includes a game-winning TD pass against Mississippi State. Early injury reports render it unlikely that Manning will play in Week 10 against Vanderbilt.

Texas is now just 2-6 ATS on the season, compared to a 6-2 ATS mark for the Commodores, who have smashed all preseason expectations. Vandy was picked to finish 13th in the SEC preseason media poll, and 14th by ESPN.