Arizona State vs Colorado Prediction, Props & Saturday Night CFB Odds 

• No. 25 Arizona State heads to Boulder to face Colorado
• The Buffaloes are seven-point underdogs to the Sun Devils
• See our Arizona State vs Colorado prediction, props, and Saturday night CFB odds

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Can Colorado put a stop to their current losing skid? The Buffaloes have dropped three straight and are looking to get back in the win column when they host Arizona State at 8:00 PM ET on Saturday night at Folsom Field in Boulder, Colorado. ESPN2 will have coverage of the game.

Let’s take a deeper look at this matchup with our Arizona State vs Colorado prediction, props, and Saturday night CFB odds.

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Arizona State vs Colorado Prediction

• Spread Pick: Colorado +7 (-110 at Bet365)
• Total Pick: Under 47 (-110 at Bet365)

I’m backing the Buffs to cover the seven-point spread in what should be a defensive struggle. While Colorado has lost three straight, they’re at home and getting a touchdown against an inconsistent Arizona State offense.

While the Buffaloes are in the middle of a three-game losing streak, the Sun Devils are actually seeking their third straight win. Arizona State is coming off victories at Iowa State (24-19) and against West Virginia (25-23).

Let’s work 🦾 pic.twitter.com/k1Tk409gwM

— Colorado Buffaloes Football (@CUBuffsFootball) November 18, 2025

Oddsmakers opened ASU as high as a nine-point favorite, but the line has since tightened to -7. The total opened around 47.5 and has dipped a half point to 47.

The Sun Devils are 5-5 against the spread, while hitting the game total over in seven out of 10 games this season. On the other side, the Buffs are 3-7 ATS and have hit the under in seven out of 10 contests.

For this game, the attention on the under makes sense. The Sun Devils’ offense has been volatile all season, ranking 78th in EPA per play and 74th in success rate. They’re also running into a respectable Colorado defense that sits 57th in EPA per play and 60th in success rate allowed.

Flipping to the other side, Colorado’s offense has struggled all season, ranking 105th in success rate, and now draws an Arizona State defense that’s 49th in success rate allowed. It’s hard to envision the Buffaloes suddenly exploding in this matchup, making our Arizona State vs Colorado prediction lean toward a defensive battle.

The Sun Devils are led by senior quarterback Jeff Sims, who in four games has thrown for 566 yards with five touchdowns and one interception. His 55.4% completion rate remains shaky, but he’s added 411 rushing yards and two scores on the ground.

Colorado freshman quarterback Julian Lewis gets the nod for Deion Sanders. In his latest outing at West Virginia, he completed 22 of 35 passes for 299 yards with two touchdowns and no interceptions. The young signal-caller has shown promise despite the Buffs’ recent struggles.

JULIAN LEWIS FULL HIGHLIGHTS VS WEST VIRGINIA:

299 PASSING YARDS-2 TDS-63% CMP-0 INT

The future is bright. pic.twitter.com/cd3E3UUWm5

— GUCCE🦬🐦‍⬛ (@gucceCU) November 8, 2025

Lewis’ potential is much higher than Sims’. Sims is in his sixth year of college football—he’s dangerous with his legs but still turnover-prone. Lewis is young, raw, and still developing, but Saturday night will give us a clearer picture of what he’s capable of against one of the better defenses he’ll see.

I’m aligned with the market move—I like Colorado to cover the +7, and I do lean toward this being a lower-scoring matchup. The Buffaloes ATS is the stronger play in my Arizona State vs Colorado prediction.

Arizona State vs Colorado Props

• Prop Pick: Jeff Sims Under 197.5 Passing Yards (-115 at Bet365)

A prop I’m targeting is fading Jeff Sims. The senior quarterback is not known for having a lethal, consistent arm. Even if he does get a healthy dose of attempts, he’ll likely struggle to get into a rhythm, considering his subpar completion percentage throughout his career.

I’m taking under 193.5 passing yards at -122. Colorado’s pass defense is allowing fewer than 210 passing yards per game, and Sims is far more comfortable scrambling than consistently throwing. In a defensive-tilted game, his passing output should stay limited. He may have a few flashy throws here and there, but ultimately, he won’t get enough action or time in the pocket to eclipse this prop mark.

Jeff Sims had no idea he broke ASU's single-game rushing yards by a QB record after the team's win over Iowa State.

Here's his reaction when he found out😂 pic.twitter.com/vnX7Jw3z55

— Gabriella Chernoff (@GabbyJChernoff) November 1, 2025

This prop aligns perfectly with our overall Arizona State vs Colorado prediction of a low-scoring, defensive battle where both quarterbacks will face pressure throughout the night.

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Arizona State vs Colorado Odds – Saturday Night CFB

Odds as of Nov. 22, at Bet365 Sportsbook. Bet on ASU vs Colorado tonight by registering with a Bet365 bonus code.

The Saturday night CFB odds reflect Arizona State’s recent momentum and the Buffs’ ongoing struggles. With the Sun Devils favored by a touchdown and the total set at 47, bettors should consider both teams’ defensive strengths when making their wagers on this Big-12 showdown.