Seahawks vs 49ers Picks, Predictions & Betting Splits (Jan. 3)

• The Seahawks visit the 49res in a massive Week 18 game
• The winner will get the top seed and lone bye in the NFC
• See the Seahawks vs 49ers picks, predictions, betting splits, and latest odds for Jan. 3

A massive NFC West clash kicks off Week 18 as the Seattle Seahawks (13-3, 7-1 away, 11-5 ATS, 9-7 O/U) visit the San Francisco 49ers (12-4, 5-2 home, 11-5 ATS, 10-6 O/U) with the NFC #1 seed in the NFL playoff bracket on the line. The winner will get to rest next week while the loser is relegated to a road game on Wild Card weekend.

Seattle enters Levi’s Stadium as a slight road favorite. The game is set for a primetime kickoff on Saturday, January 3rd, at 8:00 pm ET, broadcast nationally on ABC/ESPN. This article will break down everything bettors need to know, from odds and key statistics to public-betting trends and my final Seahawks vs 49ers picks predictions.

Seahawks vs 49ers Picks & Predictions

This NFC West showdown profiles as a classic clash of offensive styles. The visiting Seahawks bring a high-volume scoring attack that averages 29.0 points per game, while the 49ers counter with a methodical, hyper-efficient offense that excels in critical situations. While Seattle is the slight road favorite, the underlying metrics suggest the 49ers possess the key advantages needed to secure a win at home.

Moneyline Pick: San Francisco 49ers (+108) at FanDuel Sportsbook

The 49ers’ offensive identity is built on sustaining drives and capitalizing on scoring opportunities. Their phenomenal 51.0% third-down conversion rate is one of the best in the league and stands in stark contrast to Seattle’s 39.4% mark. This situational mastery extends to the red zone, where San Francisco scores touchdowns at an impressive 66.2% clip, compared to 57.1% for the Seahawks.

In a game with a razor-thin spread, the ability to avoid field goals and punch it in for six is a decisive factor.

While Seattle boasts a fearsome pass rush that has accumulated 44.0 sacks, San Francisco’s offense is built to mitigate that pressure. The potential absence of star tackle Trent Williams is a concern, but the 49ers’ system is predicated on rhythm and getting the ball out quickly.

Given the 49ers’ superior efficiency on crucial downs and the value of getting them as home underdogs, the moneyline presents the most attractive straight bet.

Game-Total Pick: Over 47.5 (-110) at bet365

Two top-tier offenses are set to trade blows. Seattle averages 29.0 points per game, while the 49ers put up 26.9. The 49ers’ offensive efficiency should translate long drives into points, while the Seahawks’ aggressive attack will do its part to push the total.

With both teams posting negative turnover differentials, the potential for short fields and quick scores for both sides is elevated.

Best Player Prop: George Kittle Over 5.5 Receptions (-105) at DraftKings

Despite being on the injury report, Kittle is the engine of the 49ers’ passing game over the middle. Against Seattle’s potent pass rush (44.0 sacks), expect Brock Purdy to rely on quick, high-percentage throws to his most reliable target.

Kittle is a go-to receiver on third down, and with the 49ers converting over half of their attempts, he will have ample opportunity to rack up catches. His role as a safety valve and chain-mover makes this a strong bet to hit.

Seattle Seahawks vs San Francisco 49ers Odds

The latest NFL odds show the 49ers as long as +108 at FanDuel, while Caesars Sportsbook has the best moneyline price on the Seahawks at -124.

The spread is Seattle -1.5 across the board. Caesars once again has the best price on Seattle (-109 to cover) while DraftKings Sportsbook has the best price on San Francisco to cover (-102).

The total ranges from 47.5 to 48.0. Over bettors should take 47.5 (-110) at bet365; under bettors should take 48.0 (-110) at BetMGM.

Public Betting Trends for Seahawks vs 49ers

An analysis of the NFL public betting markets reveals where the majority of the money is flowing for this NFC West finale. While the moneyline shows a slight lean, bettors have taken a strong stance on both the point spread and the game total.

Here is a breakdown of where the money is going:

• Spread: A significant majority of the handle (61%) is backing the San Francisco 49ers to cover at home.
• Moneyline: The money is leaning toward the home underdog, with 59% of the cash on the San Francisco 49ers to win the game outright.
• Total: There is heavy action on the under, which is attracting 64% of the total money wagered.

Injury Report for Seahawks vs 49ers Week 18

SEA vs SF Team Stats Comparison

All stats from 2025 regular season.

While both teams boast offenses that are trending upwards, their methods for moving the ball and putting points on the board differ significantly. Seattle relies on explosive, high-volume scoring, while San Francisco leans on methodical, hyper-efficient drives that control the clock and capitalize on every opportunity.

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