Final LSU vs Ole Miss Prediction, Picks & Updated Odds (Sep. 19)
By Chris Amberley in College Football
Published:
- LSU vs Ole Miss brings Lane Kiffin back to Oxford for Saturday’s SEC showdown
- My LSU vs Ole Miss prediction is on the Tigers now that Sam Leavitt is ready to go
- See my Final LSU vs Ole Miss prediction, picks and updated odds for Sep. 19, below
Lane Kiffin returns to Oxford as LSU’s head coach tonight, with Pete Golding’s Ole Miss team waiting at Vaught-Hemingway Stadium. Both programs are 2-0 entering the 7:30 p.m. ET game on ABC.
LSU has beaten Clemson 51-10 and Louisiana Tech 45-14. Ole Miss opened with a 41-38 win over Louisville before defeating Charlotte 41-9, setting up a meeting between two offenses that have started quickly.
My LSU vs Ole Miss prediction weighs the Tigers’ defensive production and their offensive now that Sam Leavitt is expected to start. The prediction, best picks and updated market prices follow.
Prediction | Best picks | Updated odds
Final LSU vs Ole Miss Prediction
- My prediction: LSU wins. My bet: Kalshi Yes at 59¢.
I’m picking LSU to win in Oxford, with the Tigers’ pass rush making the difference. Sam Leavitt has gone from doubtful to questionable to now expected to start over the course of the last few days, and his availability was the key to me ultimately siding the Tigers. See our Kalshi promo code guide for the current offer.
Leavitt has thrown for 574 yards and accounted for nine total touchdowns through two games. I like how his passing complements a rushing attack that has already produced 456 yards and eight scores. That balance gives LSU more ways to sustain drives than relying on one receiver to win downfield.
LSU’s defense is the biggest reason I favor the Tigers. They have allowed 12 points and 221.5 yards per game, with 10 sacks and 17 tackles for loss through two outings. I expect that pressure to disrupt Ole Miss often enough to give LSU the edge in a close game.
Trinidad Chambliss has thrown for 561 yards and five touchdowns for the Rebels. I expect LSU to make him work through longer passing situations by winning on early downs. A sack or tackle for loss can be especially costly here, forcing Ole Miss away from the quick completions that keep its offense moving.
LSU vs Ole Miss Picks
- My best bet: LSU to win, Yes at 59¢.
I prefer LSU to win outright rather than cover the spread. The winner contract costs 59¢, compared with 55¢ for LSU to win by more than 2.5 points. I’m willing to pay that difference so a one- or two-point Tigers win still cashes my bet.
Ole Miss has a reliable scoring threat in Kewan Lacy, who has scored a rushing touchdown in 11 straight games dating to 2025. He ran for 87 yards and two touchdowns against Charlotte. LSU cannot focus solely on pressuring Chambliss and leave Lacy easy opportunities to sustain drives.
Deuce Alexander adds another problem for the Tigers. He has 235 receiving yards through two games and caught all eight of his targets for 76 yards last week. Keeping those completions short would help LSU force Ole Miss to repeatedly execute rather than turn one catch into a scoring possession.
I lean over 58.5, but LSU to win is my only recommended bet. Both offenses can score quickly, yet a strong night from the Tigers’ defense could keep the total down while still delivering the result I’m backing.
LSU vs Ole Miss Updated Odds
Kalshi buy prices checked September 18. See our college football betting apps for more options.
Buying LSU at 59¢ therefore produces 41¢ in profit before fees if the Tigers win. The separate 42¢ No quote is a purchase price for the opposite outcome, not the profit on a winning LSU Yes contract.
The spread contract requires LSU to win by at least three points, while Over 58.5 needs 59 combined points. At 59¢ for an outright win, I prefer the Tigers without a margin requirement. That is my final LSU vs Ole Miss prediction: LSU wins, with the moneyline-style contract as my best bet.
Sports Writer
As SBD's resident Swiss Army Knife, Chris covers virtually every sport including NFL, PGA, NBA, MLB, NCAAB, NCAAF and the Olympics. A true grinder, he'd rather pick off small edges in the player props market than swing for the fences with a 5-leg parlay.
