Cardinals vs Seahawks Predictions, Injuries & Betting Splits

• The 3-5 Cardinals take on the 4-4 Seahawks Sunday afternoon in Seattle
• Arizona has won two of three while the Seahawks have dropped three of their last four
• Keep reading for Cardinals vs Seahawks odds, NFL player props and public betting splits

The Seattle Seahawks (4-4-0 SU, 2-4-2 ATS, 4-4-0 O/U) host the Arizona Cardinals (3-5-0 SU, 4-4-0 ATS, 5-3-0 O/U) for a critical NFC West battle at Lumen Field Sunday. Kickoff is slated for 1:25 PM PT / 4:25 PM ET on FOX. Seattle steps onto the turf reeling from a recent loss and a ravaged injury report.

Starting quarterback Sam Darnold is sidelined with a quad injury, meaning Drew Lock takes the reins under center. The defense also takes a hit with linebacker Uchenna Nwosu and defensive tackle Leonard Williams ruled out. The Cardinals enter off an OT victory over Dallas and look to engineer a divisional upset. Below I break down the NFL odds and dial in the best value for this Week 9 duel.

Cardinals vs Seahawks Predictions & Expert Picks

These units mirror each other. Arizona logs 333.0 total net yards per game compared to Seattle’s 331.9. The scoring output is nearly identical, with the Seahawks averaging 23.1 points per game and the Cardinals producing 21.9. I am always hesitant to back a heavy favorite deploying a backup quarterback. Asking Drew Lock to cover more than a touchdown against a defense that has already generated 19.0 sacks is a tall order, despite his success vs Arizona in Week 2 (19-26, 235 yds, 3 TD’s).

ATS Pick: Arizona Cardinals +9.5 (-113, Kalshi)
The 9.5-point spread feels inflated given the quarterback swap. Seattle boasts a stingy pass defense, but relying on their backup signal-caller to separate by two scores is risky. Arizona’s ability to match Seattle in total yardage gives them the leverage piece needed to keep this within the number.

Arizona’s primary equalizer lies in early-down rushing efficiency, where the Cardinals generate 4.8 yards per carry and rank 11th in rush success rate. Seattle’s defense allows 118.4 yards on the ground per game, giving Arizona a direct blueprint to sustain drives, bleed clock, and minimize pass-rush exposure for Gardner Minshew. Of course, the Cards are also starting ostensibly their backup QB after trading Jacoby Brissett away. Minshew came in last weekend in relief vs the Cowboys and went 17-23 for 188 yards and 3 TD’s.

On the other side, Lock’s career 3.2% interception rate and vulnerability under duress make it difficult for Seattle to generate explosive separation against an Arizona pass rush generating pressure on 34.2% of snaps.

Game-Total Pick: Under 38.5 (+117, Novig)
Both squads struggle finishing drives. Seattle converts just 46.4% of red zone trips into touchdowns, while Arizona sits at 45.5%. Expect drives to stall between the 20-yard lines, creating a field position battle dominated by punts and field goals. While sportsbooks list the Under at +100, buying ‘No’ shares on Over 38.5 points for 47¢ on Kalshi offers superior payout value.

With Seattle surrendering an NFL-low 156.0 passing yards per contest and both teams ranking among the league leaders in punt percentage inside opposing territory, reaching 39 total points requires an unrealistic surge in sudden-change scoring plays.

Best Player Prop Edge: Trey McBride 62+ Receiving Yards (-108, Novig)
Cardinals receiver Michael Wilson was limited in practice due to rest. Tight end Trey McBride should dominate the target share. Seattle surrenders just 156.0 passing yards per game, forcing Gardner Minshew to rely on high-percentage, underneath throws to his tight end to move the chains. Look to the sports betting picks market to capitalize on this volume.

McBride operates as the undisputed alpha pass-catcher in this offense, commanding an elite 28.4% target share and running routes on 86.8% of Minshew’s dropbacks.

Averaging 7.4 targets and 68.2 yards per contest over his last six games, McBride’s massive target volume gives him a rock-solid floor to clear 62 yards.

Cardinals vs Seahawks Public-Betting Trends

• Spread Money: Seattle (52.9%) | Arizona (47.1%)
• Total Money: Under (51.9%) | Over (48.1%)
• Moneyline Money: Seattle (71.1%) | Arizona (28.9%)

The NFL public betting data shows a slight majority laying the points with the hometown favorite, contrasting my Arizona +9.5 recommendation. However, the Under 38.5 prediction aligns perfectly with the market, as 51.9% of the handle backs a low-scoring script. Unsurprisingly, the heavy moneyline favorite commands 71.1% of the outright winner cash.

ARI vs SEA Odds (Week 9)

Odds as of Sunday, November 8 at 9:58 AM ET from theScore Bet.

Seahawks vs Cardinals Injury Reports

Seahawks vs Cardinals Team Stats