AI College Football Picks Week 11: Computer Predictions for Spreads & Totals

• Georgia holds the No. 1 spot in the CFP rankings at 8-1 ahead of hosting Missouri
• Utah is 9-0 and No. 2, and the model makes the Utes a short road favorite at Arizona
• See below for all 20 Week 11 picks, five matchup breakdowns and last week’s results

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The Sportradar model went 7-3 against the spread and 7-3 on totals for a 14-6 board, with no pushes anywhere on the card.

That lifts the season to 52-48-1 ATS and 52-49 on totals, or 104-97-1 overall.

The AI college football picks for Week 11 cover 10 games on the November 14 slate. Here is the full card, followed by five matchups worth a closer look.

Week 11 College Football AI Picks

The totals split five overs and five unders. Eight of the sides back a favorite, with Vanderbilt and Texas the two underdog calls that stand out most on the board.

Vanderbilt plus 15.5 is the biggest number the model is taking points on. Alabama is No. 3 in the CFP rankings at 7-2 after a 31-13 win at LSU, so that one asks a lot of the home side.

These are the lines each selection was recorded against. Four do not match BetMGM’s main numbers as of early November 11, where Miami sits at -13, Oregon at -11, Notre Dame at -29 and the Texas game total at 45.5, so compare the live college football odds before betting.

Texas at LSU Prediction & AI Picks

• Spread pick: Texas +4
• Total pick: Over 46.5

Texas is No. 6 in the CFP rankings at 7-2 and LSU is No. 21 at 6-3, yet the Tigers are the home favorite. Kickoff is 7:30 p.m. ET on ABC at Tiger Stadium.

Arch Manning was sharp in the 34-20 win at Missouri. He completed 28 of 38 passes for 297 yards and three touchdowns, with every one of those scores covering more than 20 yards.

LSU moved the ball in its 31-13 loss to Alabama without turning it into points. Sam Leavitt threw for 380 yards in that game and the Tigers still managed only 13.

The model takes the points and the over 46.5. Two offenses that both cleared 290 passing yards last week support the total, and this is a game worth price shopping across sportsbooks and the prediction market apps.

USC at Indiana Prediction & AI Picks

• Spread pick: Indiana -7.5
• Total pick: Under 50.5

Indiana is 8-1 and 5-1 in the Big Ten, with USC at 7-2 and 4-2. Both teams are coming off open dates, and kickoff is 3:30 p.m. ET on CBS.

The Hoosiers average 32.4 points and allow 12.4, but their own preview notes the scoring average slipped to 17.8 over the previous month. That drop is the clearest support for an under here.

Indiana’s pass rush is the other half of it. The Hoosiers have 76 tackles for loss and 32 sacks, with Tobi Osunsanmi accounting for 15.5 and 10 of those himself.

Curt Cignetti has not named a starting quarterback between Josh Hoover and Grant Wilson. Hoover has 1,860 yards with 19 touchdowns and two picks, while Wilson has 230 yards and three scores in relief.

Jayden Maiava gives USC the more settled situation at 2,524 yards, 20 touchdowns and five interceptions. The Trojans also allow 24.2 points a game, which is where the 7.5 comes from.

Utah at Arizona Prediction & AI Picks

• Spread pick: Utah -2.5
• Total pick: Over 54.5

Utah is 9-0 and 6-0 in the Big 12 with 15 straight wins, visiting a 7-2 Arizona team that sits No. 23 in the CFP rankings. Kickoff is 7:30 p.m. ET on FOX in Tucson.

Devon Dampier did everything in the 28-20 win over BYU. He threw for 177 yards and two touchdowns, ran for 89 yards and two more, and added a 29-yard catch.

The Utes have also been starting fast, outscoring opponents 103-9 in the first quarter. Only a 2.5-point spread for a team playing like that is the reason the model lays it on the road.

Utah allows 103.3 rushing yards a game with a 106.28 defensive passing efficiency rating. The over 54.5 is the bolder half of this card, since it needs Arizona to answer rather than get buried early.

Texas Tech at Oklahoma State Prediction & AI Picks

• Spread pick: Oklahoma State -3.5
• Total pick: Under 72.5

Texas Tech is No. 12 at 8-1 and Oklahoma State is No. 25 at 6-3, with a 9:30 p.m. ET kickoff on ESPN. The 72.5 total is 18 points higher than anything else on the board.

Both teams earned that number last week. Tech outlasted West Virginia 53-48 and Oklahoma State ran past Kansas State 66-28, so the market is pricing in another track meet.

The Red Raiders have owned the fourth quarter all season. They shut out West Virginia 12-0 in the final period, part of a plus-67 fourth-quarter differential.

The model takes the home side and the under. Tech also controls its path to the Big 12 title game by winning its final three, which is plenty of reason to grind out a tighter game.

Duke at Miami Prediction & AI Picks

• Spread pick: Miami (FL) -13.5
• Total pick: Under 54.5

Miami hosts Duke at noon ET on ABC after a 31-24 loss at Notre Dame ended its unbeaten start. This is the earliest window on the Week 11 board.

Duke arrives playing its best defense of the season. The Blue Devils won 41-3 at NC State and allowed 75 second-half yards, including minus-4 rushing, for their fourth second-half shutout.

Nate Sheppard is the engine. He has 1,189 rushing yards and 17 scores on 191 carries, plus 32 catches for 306 yards and four more, and Duke lists him as the national leader with 21 total touchdowns.

That workload is why the under fits alongside a 13.5-point favorite. Malachi Toney also missed the Notre Dame game with a practice injury, and no designation has been announced for Saturday.

College Football AI Picks: Week 10 Results

The Week 10 college football AI picks went 7-3 against the spread and 7-3 on totals for a 14-6 board. No selection landed on the number, so there were no pushes.

Five games delivered both sides of the card. Utah, Oklahoma State, Oregon, Tennessee and Georgia all covered while their totals cashed in the same game.

Miami at Notre Dame was the only game to miss twice. The season now sits at 52-48-1 ATS and 52-49 on totals, or 104-97-1 overall for the season.