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Duke vs Houston Odds for Sweet 16 Matchup – Cougars Open as Favorites Over Blue Devils

Matt McEwan

by Matt McEwan in College Basketball

Updated Mar 24, 2024 · 9:01 PM PDT

Duke's bench celebrating a three
Mar 24, 2024; Brooklyn, NY, USA; Duke Blue Devils guard Tyrese Proctor (5) reacts after making a basket against the James Madison Dukes in the second round of the 2024 NCAA Tournament at Barclays Center. Mandatory Credit: Robert Deutsch-USA TODAY Sports
  • Duke will take on Houston in the Sweet 16 of the March Madness tournament
  • The Blue Devils steamrolled James Madison in the second round, while Houston took care of business against Texas A&M
  • See the odds for Duke vs Houston below

Duke absolutely crushed #12 James Madison 93-55 in the second round of the March Madness tournament. The Blue Devils started the game hot from behind the three-point line and never cooled off. They carried a 22-point lead into halftime and only built upon it in the second half.

Houston’s Round of 32 matchup with Texas A&M was much closer, as the largest lead by either side was just 13 points and the South Region’s top seed was given a late-game scare. The team given the second-best odds to win the NCAA Tournament watched their opponent hit a three at the buzzer to force overtime, and had to play without two of their stars for most of the extra period. The #1 Houston Cougars did hang on to beat the Aggies 100-95, though, advancing to the Sweet 16 to take on Duke.

The game is scheduled for Friday, March 29 at 9:39pm ET. (However, tip-off might come a little later since the official timing is “after the conclusion of NC State vs Marquette.”) The opening odds for Duke vs Houston in the Sweet 16 favor Houston.

Duke vs Houston Odds

Team Spread Total Moneyline
Duke +4 (-110) O 133 (-110) +160
Houston -4 (-110) U 133 (-110) -192

Houston opened as 4-point favorites over Duke in their Sweet 16 matchup.

Houston’s moneyline odds are set at -192 and Duke’s at +160. Based off those odds, Houston has a 65.8% chance to win the game. If you bet $20 on Houston to win, you would stand to profit $10.42 and return $30.42. That same $20 bet on Duke would win $32 and return $52.

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The over/under for total points in Duke vs Houston has opened at 133, which is by far the lowest of the Sweet 16.

The opening odds above are from DraftKings on Sunday, March 24. To see the the latest lines, see our college basketball odds.

Duke Makes Quick Work of James Madison in Round of 32

After convincingly beating #5 Wisconsin in the first round of the NCAA Tournament, James Madison had become a bit of a tournament sweetheart. The vast majority of the ATS money bet on the JMU vs Duke game was indeed on the Dukes. But their backers were silenced pretty quickly, as Duke took a 10-point lead just five minutes into the game, and the Blue Devils never let up.

It didn’t help that Terrence Edwards Jr, the Dukes’ best player and the Sun Belt Player of the Year, found himself in foul trouble early in the game, forcing him to the bench.

The Blue Devils opened the game shooting the ball well, but it was their effort on the offensive glass that led to some open shots to get the team going. Duke finished the game shooting 52.4% from the field but were a scorching 50% from downtown, making 14 of their 28 attempts. Jared McCain was incredible, going 8-11 from three while pouring in 30 points.

Duke’s offense was impressive all night, specifically with their ball movement. They recorded 22 assists to James Madison’s seven. Not only were they creating open shots by sharing the ball, but also continued to find the hot hands.

If Duke shoots the ball this well, they’re going to be tough for anyone. However, thanks an extremely tough matchup ahead in the Sweet 16, Duke now has the third-best odds to make the Final Four.

Houston Outlasts Texas A&M in Second Round

Though it was far from Houston’s best performance of the year, the Cougars always felt in control of their second round matchup with Texas A&M.

Houston gave up ten offensive rebounds in the first half and committed 14 personal fouls before the break. All the fouls led to Texas A&M shooting 22 free throws in the first half alone, but were only able to hit 11 of them. LJ Cryer, who shot 39.1% from behind the three-point line this season, and Jamal Shead, who was a 32.1% three-point shooter entering this one, combined to go 0-8 from downtown in the first half. In spite of all that, Houston still led by five entering the second half.

The first 15 minutes of the second half was much better than the first for Kelvin Sampson’s squad. However, they would finish the game allowing 22 offensive rebounds, allowing A&M to add another 12 in the second half, and still committed 14 more fouls after the break. The offense remained a little off and they committed a few bad, uncharacteristic turnovers, but the defense flexed their muscle for about 15 of the 20 minutes.

The most concerning part for Houston has to be the way they crumbled in the last couple minutes of the game, as Texas A&M ramped up the pressure. Houston’s offense failed to put the game away as they committed some bad turnovers and missed some open shots. Their defense all of a sudden reverted back to the one we saw in the first half, giving up offensive rebounds and committing bad fouls. The Cougars allowed the Aggies three chances to tie the game in the final seconds, with A&M hitting the final three-point attempt at the buzzer to force overtime.

Even without LJ Cryer, who fouled out with a few minutes left in the second half, for the entire overtime period and losing Emanuel Sharp (their leading scorer) very early in overtime, as well as the momentum working against them after allowing A&M to tie it at the buzzer, Houston would still hold on and escape the first weekend, beating A&M 100-95.

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