Opening College Football Week 0 Odds, Spreads and Early Predictions

• The college football season begins Saturday with seven games involving two FBS teams
• The top matchup of the week has Nebraska and Northwestern playing in Dublin, Ireland
• The full list of opening college football Week 0 odds and lines can be found below

It’s still August, but the college football season begins Saturday (August 27) with a handful of Week 0 games.

No ranked teams will be in action.

There is one game involving two Power Five programs, as Nebraska and Northwestern meet in a Big Ten matchup at Dublin, Ireland. The Cornhuskers are favored by 13 points.

Here is a look at the Week 0 opening college football odds.

College Football Week 0 Opening Odds

Odds as of August 21st at DraftKings.

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It’s American Football, Laddies

This is a pivotal year for Nebraska coach Scott Frost, whose salary was cut ahead of his fifth season at his alma mater. The Cornhuskers were just 3-9 last season.

Mark Whipple has been brought in as offensive coordinator. He will have a new quarterback to work with in Casey Thompson, a transfer from Texas.

Lineman Ochaun Mathias transferred from TCU to bolster an already solid defense. Linebacker Garrett Nelson is also a key cog on that side of the ball.

Good start. Casey Thompson steps into his throws #Huskers instead of happy feet pic.twitter.com/RMBGSJXx85

— What does the film say? (@Huskers_film) August 16, 2022

Northwestern also went 3-9 last season only a year after appearing in the Big Ten Championship Game.

The Wildcats are counting on improvement from returning quarterback Ryan Hilinski. They also have a 1,000-yard rusher in Evan Hull.

Lineman Adetomiwa Adebawore is a fierce pass rusher. However, he needs help from some of his teammates on that unit.

It is a little risky to lay double digits with Nebraska and Frost. The Cornhuskers, though, should be motivated to get off to a good start in a pivotal season for the once-proud program.

Pick: Nebraska -13 (-110)

No Respect for Mora

Connecticut has long been one of the dregs of college football, but the Huskies being 27-point underdogs at Utah State seems a touch high.

Jim Mora Jr. takes over as UConn’s coach. He gives the program instant credibility after head coaching stints at UCLA and in the NFL with the Seattle Seahawks.

Though UConn was 1-11 last season, Penn State transfer quarterback Ta’Quan Roberson should give the offense an immediate boost.

QB Ta’Quan Roberson takes snaps at the left side of the field while Qb Tyler Phommachanh does so on the opposite end. pic.twitter.com/SJEQXrYUxb

— UConn Insider (@UConn_Insider) August 17, 2022

Utah State was a surprising 11-3 last season and played in the Mountain West Conference Championship Game. The Aggies were just 1-5 in the pandemic-shortened 2020 season.

Quarterback Logan Bonner threw for 3,628 yards and 36 touchdowns last season. However, Utah State’s porous defense – it allowed almost 400 yards a game in 2021 – makes the 27-point spread seem high.