Opening College Football Week 10 Odds, Spreads and Early Predictions

• Week 10 of the college football season begins in earnest Thursday night when #24 Louisiana-Lafayette hosts Georgia State
• The top matchup of the week has #12 Auburn visiting #13 Texas A&M
• The full list of Week 10 opening lines and odds can be found below with a prediction

A matchup of two of the top teams in the SEC highlight Week 10 of college football.

#12 Auburn visits #13 Texas A&M at 3:30 p.m. Saturday at Kyle Field in College Station. Both teams are 6-2 and the Aggies have opened as a four-point favorite.

The game between the Tigers and Aggies is the only one on the schedule featuring two ranked teams in a rather lackluster weekend ahead.

Here is a look at all the Week 10 opening lines:

College Football Week 10 Opening Odds

Odds as of October 31st at DraftKings.

Auburn Faces Another Test in A&M

Auburn beat then-#10 Ole Miss 31-20 on Saturday at home as Bo Nix passed for 276 yards and a touchdown and ran for two scores.

Bo Nix is the king of schoolyard QB scrambles pic.twitter.com/bCQjuc236I

— Patrick Greenfield (@PCGreenfield) October 30, 2021

Jaylin Simpson had a key fourth-quarter interception for the Tigers. Auburn held Ole Miss on fourth down three times in the second half.

Tank Bigsby ran for 140 yards and a TD as the Tigers won their second game in a row.

Texas A&M has won three straight games since back-to-back losses to Arkansas and Mississippi State. The Aggies had this weekend off after rolling to a 44-14 victory over visiting South Carolina on Oct. 23.

During its winning streak, Texas A&M is averaging 40.0 points a game. That figure is up from 28.5 over the Aggies’ first five games.

Zach Calzada with the 70 yard 💣 to Demond Demas for an Aggie TD!!https://t.co/pcYH1atBDG

— PFF College (@PFF_College) September 18, 2021

While Texas A&M has plenty of momentum, Nix can beat teams with both his arm and legs. Thus, Auburn looks like a good bet with 4 points.

UTSA, UTEP Battle for First in C-USA

In a week devoid of big games, one of the more interesting matchups has #16 UTSA (8-0) visiting UTEP (6-2) at 10:15 p.m. ET Saturday in a showdown for first place in the Sun Belt Conference at the Sun Bowl in El Paso.

UTSA is the second-highest team in the polls among the Group of Five teams after Cincinnati are favored by 11.5 points. The Roadrunners beat Louisiana Tech 45-16 on the road Oct. 23 then had a bye this past week.

UTSA has soared to the highest national rankings in program history this week.

🔗 https://t.co/VuqBl030G9#210TriangleOfToughness | #BirdsUp 🤙 pic.twitter.com/gN5P0qEHQC

— UTSA Football 🏈 (@UTSAFTBL) October 31, 2021

UTSA has played only one Power Five school, winning 37-30 at Illinois in its opener.

UTEP lost at Florida Atlantic 28-25 on Saturday, ending its four-game winning streak. The Miners trailed 28-10 in the fourth quarter, but their comeback bid fell short.

Gavin Hardison threw for 337 yards and two touchdowns as UTEP held a 454-279 advantage in total yards. However, Florida Atlantic intercepted Hardison twice.

2Q | @GavinHardison12 completes a 23-yard TD to TE Trent Thompson!

⛏ 10
🦉 7

⏰ 1:42 pic.twitter.com/Ab7tSyGN1P

— UTEP Football (@UTEPFB) October 30, 2021

UTSA is clearly the class of C-USA and will cover the big number on the road.

Boise State Still Has Appeal

Fresno State reentered the Associated Press media poll at #25 after upsetting then-#21 San Diego State on the road 30-20 on Saturday night. The Bulldogs also knocked off then-#13 UCLA at the Rose Bowl on Sept. 18.

Fresno State (7-2) is on a three-game winning streak as it hosts Boise State on Saturday and is a 5-point pick.

Boise State is just 4-4 this season but the Broncos remain a brand-name Group of Five program to bettors. Thus, look for this line to drop a little bit during the week.