Opening College Football Week 6 Odds, Spreads and Early Predictions
- College football Week 6 starts Thursday night with Kansas State visiting Oklahoma State
- Oklahoma and Texas, both unbeaten meet in the annual Red River Showdown in Dallas
- A look at all the opening NCAAF Week 6 odds can be found below with picks
The Power Five portion of college football Week 6 starts Friday night when Oklahoma State hosts Kansas State in a Big 12 game.
Kansas State (3-1) is a nine-point opening favorite. Oklahoma State (2-2) is coming off back-to-back losses.
There are four games among ranked teams, including #12 Oklahoma vs #3 Texas, #23 LSU vs #21 Missouri, #20 Kentucky vs #1 Georgia and #10 Notre Dame vs #25 Louisville.
The college football odds will be updated throughout the week.
College Football Week 6 Opening Odds
| Game Time (Eastern) | Team | Spread | Moneyline |
|---|---|---|---|
| 7:30 p.m. | Kansas State | -9 (-110) | OFF |
| Friday, Oct. 6 | Oklahoma State | +9 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| 8 p.m. | Nebraska | +3 (-110) | OFF |
| Friday, Oct. 6 | Illinois | -3 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| 12 p.m. | Boston College | +4 (-110) | OFF |
| Saturday, Oct. 7 | Army | -4 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| 12 p.m. | Western Michigan | +21.5 (-110) | OFF |
| Saturday, Oct. 7 | Mississippi State | -21.5 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| 12 p.m. | Maryland | +19 (-110) | OFF |
| Saturday, Oct. 7 | Ohio State | -19 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| 12 p.m. | Rutgers | +14 (-110) | OFF |
| Saturday, Oct. 7 | Wisconsin | -14 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| 12 p.m. | LSU | -6.5 (-110) | OFF |
| Saturday, Oct. 7 | Missouri | +6.5 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| 12 p.m. | Oklahoma | +5.5 (-110) | OFF |
| Saturday, Oct. 7 | Texas | -5.5 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| 2 p.m. | Marshall | +7.5 (-110) | OFF |
| Saturday, Oct. 7 | North Carolina State | -7.5 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| 3 p.m. | Washington State | +3 (-110) | OFF |
| Saturday, Oct. 7 | UCLA | -3 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| 3:30 p.m. | Wake Forest | +20.5 (-110) | OFF |
| Saturday, Oct. 7 | Clemson | -20.5 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| 3:30 p.m. | Virginia Tech | +29 (-110) | OFF |
| Saturday, Oct. 7 | Florida State | -29 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| 3:30 p.m. | Purdue | +5 (-110) | OFF |
| Saturday, Oct. 7 | Iowa | -5 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| 3:30 p.m. | Syracuse | +7.5 (-110) | OFF |
| Saturday, Oct. 7 | North Carolina | -7.5 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| 3:30 p.m. | Alabama | -3.5 (-110) | OFF |
| Saturday, Oct. 7 | Texas A&M | +3.5 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| 4 p.m. | Vanderbilt | +19.5 (-110) | OFF |
| Saturday, Oct. 7 | Florida | -19.5 (-100) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| 4 p.m. | UCF | +3 (-110) | OFF |
| Saturday, Oct. 7 | Kansas | -3 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| 6:30 p.m. | Colorado | -6.5 (-110) | OFF |
| Saturday, Oct. 7 | Arizona State | +6.5 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| 7 p.m. | Kentucky | +17 (-110) | OFF |
| Saturday, Oct. 7 | Georgia | -17 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| 7:30 p.m. | Arkansas | +12.5 (-110) | OFF |
| Saturday, Oct. 7 | Ole Miss | -12.5 (=110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| 7:30 p.m. | Michigan | -18.5 (-110) | OFF |
| Saturday, Oct. 7 | Minnesota | +18.5 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| 7:30 p.m. | Notre Dame | -6.5 (-110) | OFF |
| Saturday, Oct. 7 | Louisville | +6.5 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| 8 p.m. | Texas Tech | +3 (-110) | OFF |
| Saturday, Oct. 7 | Baylor | -3 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| 8 p.m. | TCU | -4.5 (-110) | OFF |
| Saturday, Oct. 7 | Iowa State | +4.5 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| 8 p.m. | Georgia Tech | +17 (-110) | OFF |
| Saturday, Oct. 7 | Miami | -17 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| 8 p.m. | Fresno State | -6.5 (-110) | OFF |
| Saturday, Oct. 7 | Wyoming | +6.5 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| 10 p.m. | Oregon State | -8 (-110) | OFF |
| Saturday, Oct. 7 | California | +8 (-110) | OFF |
| Game Time (Eastern) | Team | Spread | Moneyline |
| 10:30 p.m. | Arizona | +22 (-110) | OFF |
| Saturday, Oct. 7 | USC | -22 (-110) | OFF |
Florida State is the Week 6’s biggest opening favorite at 29 points over Virginia Tech. The lowest spread is three points for five different games.
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Oklahoma vs Texas Opening Odds & Prediction
It will be a Big 12 showdown of unbeaten teams when Oklahoma (5-0) meets Texas (5-0) at 12 p.m. ET Saturday in the Cotton Bowl in Dallas before both move to the SEC next season. Longhorns are five-point favorites.
Dillon Gabriel passed for 366 yards and three touchdowns and ran for two TDs on Saturday to lead Oklahoma over Iowa State 50-20. Texas beat Kansas 40-14 behind Jonathon Brooks’ 217 rushing yards and two touchdowns.
The throw. The catch. The effort 🤌 #OUDNA | 📺 FS1
— Oklahoma Football (@OU_Football) October 1, 2023
There is a lot of hype surrounding Texas, but Oklahoma is very capable of winning the game outright. The Sooners certainly look good getting points.
Pick: Oklahoma +5 (-110)
Kentucky vs Georgia Opening Odds & Prediction
Two SEC teams with unbeaten records square off when Kentucky (5-0) visits Georgia (5-0) at 7 p.m. ET Saturday at Sanford Stadium in Athens. The Bulldogs are favored by 17 points.
Kentucky defeated Florida 33-14 on Saturday as Ray Davis ran for a career-high 280 yards and scored four touchdowns. Carson Beck’s 40-yard TD pass to Brock Bowers with 2:52 left lifted Georgia to a 27-20 victory over Auburn.
How ‘bout Brock Bowers #GoDawgs | @brockbowers17 pic.twitter.com/ch8JdfsemI
— Georgia Football (@GeorgiaFootball) October 1, 2023
Georgia has been ranked #1 all season but has looked a bit hung over following back-to-back national championships. Kentucky has enough to get under the number.
Pick: Kentucky +17 (-110)
That’s Outta Line
Baylor is a three-point pick at home over Texas Tech in a meeting of 2-3 teams. However, not all 2-3 teams are created equal. Texas Tech has outscored its opponents by 42 points this season while Baylor has been outscored by 26 points.
A case can be made that the Red Raiders should be favored here.
Pick: Texas Tech +3 (-110)
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John Perrotto has been covering and writing about sports for various outlets for over 40 years. His work has appeared in the likes of USA TODAY, ESPN.com, SI.com, Forbes.com, The Associated Press, Baseball Digest, and more. John is based out of Beaver Falls, PA.
