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Opening College Football Week 6 Odds, Spreads and Early Predictions

John Perrotto

by John Perrotto in College Football

Updated Oct 1, 2023 · 12:11 PM PDT

Texas Longhorns running back Jonathon Brooks running with the ball against Kansas
Texas Longhorns running back Jonathon Brooks runs against the Kansas Jayhawks in the first half at Royal-Memorial Stadium on Saturday September 30, 2023.
  • College football Week 6 starts Thursday night with Kansas State visiting Oklahoma State
  • Oklahoma and Texas, both unbeaten meet in the annual Red River Showdown in Dallas
  • A look at all the opening NCAAF Week 6 odds can be found below with picks

The Power Five portion of college football Week 6 starts Friday night when Oklahoma State hosts Kansas State in a Big 12 game.

Kansas State (3-1) is a nine-point opening favorite. Oklahoma State (2-2) is coming off back-to-back losses.

There are four games among ranked teams, including #12 Oklahoma vs #3 Texas, #23 LSU vs #21 Missouri, #20 Kentucky vs #1 Georgia and #10 Notre Dame vs #25 Louisville.

The college football odds will be updated throughout the week.

College Football Week 6 Opening Odds

Game Time (Eastern) Team Spread Moneyline
7:30 p.m. Kansas State -9 (-110) OFF
Friday, Oct. 6 Oklahoma State +9 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
8 p.m. Nebraska +3 (-110) OFF
Friday, Oct. 6 Illinois -3 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
12 p.m. Boston College +4 (-110) OFF
Saturday, Oct. 7 Army -4 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
12 p.m. Western Michigan +21.5 (-110) OFF
Saturday, Oct. 7 Mississippi State -21.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
12 p.m. Maryland +19 (-110) OFF
Saturday, Oct. 7 Ohio State -19 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
12 p.m. Rutgers +14 (-110) OFF
Saturday, Oct. 7 Wisconsin -14 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
12 p.m. LSU -6.5 (-110) OFF
Saturday, Oct. 7 Missouri +6.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
12 p.m. Oklahoma +5.5 (-110) OFF
Saturday, Oct. 7 Texas -5.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
2 p.m. Marshall +7.5 (-110) OFF
Saturday, Oct. 7 North Carolina State -7.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
3 p.m. Washington State +3 (-110) OFF
Saturday, Oct. 7 UCLA -3 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
3:30 p.m. Wake Forest +20.5 (-110) OFF
Saturday, Oct. 7 Clemson -20.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
3:30 p.m. Virginia Tech +29 (-110) OFF
Saturday, Oct. 7 Florida State -29 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
3:30 p.m. Purdue +5 (-110) OFF
Saturday, Oct. 7 Iowa -5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
3:30 p.m. Syracuse +7.5 (-110) OFF
Saturday, Oct. 7 North Carolina -7.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
3:30 p.m. Alabama -3.5 (-110) OFF
Saturday, Oct. 7 Texas A&M +3.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
4 p.m. Vanderbilt +19.5 (-110) OFF
Saturday, Oct. 7 Florida -19.5 (-100) OFF
Game Time (Eastern) Team Spread Moneyline
4 p.m. UCF +3 (-110) OFF
Saturday, Oct. 7 Kansas -3 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
6:30 p.m. Colorado -6.5 (-110) OFF
Saturday, Oct. 7 Arizona State +6.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
7 p.m. Kentucky +17 (-110) OFF
Saturday, Oct. 7 Georgia -17 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
7:30 p.m. Arkansas +12.5 (-110) OFF
Saturday, Oct. 7 Ole Miss -12.5 (=110) OFF
Game Time (Eastern) Team Spread Moneyline
7:30 p.m. Michigan -18.5 (-110) OFF
Saturday, Oct. 7 Minnesota +18.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
7:30 p.m. Notre Dame -6.5 (-110) OFF
Saturday, Oct. 7 Louisville +6.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
8 p.m. Texas Tech +3 (-110) OFF
Saturday, Oct. 7 Baylor -3 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
8 p.m. TCU -4.5 (-110) OFF
Saturday, Oct. 7 Iowa State +4.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
8 p.m. Georgia Tech +17 (-110) OFF
Saturday, Oct. 7 Miami -17 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
8 p.m. Fresno State -6.5 (-110) OFF
Saturday, Oct. 7 Wyoming +6.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
10 p.m. Oregon State -8 (-110) OFF
Saturday, Oct. 7 California +8 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
10:30 p.m. Arizona +22 (-110) OFF
Saturday, Oct. 7 USC -22 (-110) OFF

Florida State is the Week 6’s biggest opening favorite at 29 points over Virginia Tech. The lowest spread is three points for five different games.

 

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Oklahoma vs Texas Opening Odds & Prediction

It will be a Big 12 showdown of unbeaten teams when Oklahoma (5-0) meets Texas (5-0) at 12 p.m. ET Saturday in the Cotton Bowl in Dallas before both move to the SEC next season. Longhorns are five-point favorites.

Dillon Gabriel passed for 366 yards and three touchdowns and ran for two TDs on Saturday to lead Oklahoma over Iowa State 50-20. Texas beat Kansas 40-14 behind Jonathon Brooks’ 217 rushing yards and two touchdowns.

There is a lot of hype surrounding Texas, but Oklahoma is very capable of winning the game outright. The Sooners certainly look good getting points.

Pick: Oklahoma +5 (-110)

Kentucky vs Georgia Opening Odds & Prediction

Two SEC teams with unbeaten records square off when Kentucky (5-0) visits Georgia (5-0) at 7 p.m. ET Saturday at Sanford Stadium in Athens. The Bulldogs are favored by 17 points.

Kentucky defeated Florida 33-14 on Saturday as Ray Davis ran for a career-high 280 yards and scored four touchdowns. Carson Beck’s 40-yard TD pass to Brock Bowers with 2:52 left lifted Georgia to a 27-20 victory over Auburn.

Georgia has been ranked #1 all season but has looked a bit hung over following back-to-back national championships. Kentucky has enough to get under the number.

Pick: Kentucky +17 (-110)

That’s Outta Line

Baylor is a three-point pick at home over Texas Tech in a meeting of 2-3 teams. However, not all 2-3 teams are created equal. Texas Tech has outscored its opponents by 42 points this season while Baylor has been outscored by 26 points.

A case can be made that the Red Raiders should be favored here.

Pick: Texas Tech +3 (-110)

 

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