- NFL Week 4 begins with the Packers hosting the Lions on Thursday Night Football
- The 49ers are the biggest favorites at 14 points over the Cardinals
- A look at the opening NFL Week 4 odds can be found below with early predictions
NFL Week 4 begins when the Detroit Lions visit the Green Bay Packers on Thursday Night Football.
The Packers are 1.5-point favorites on the opening line in the NFL odds. The Packers rallied from 17 points down to beat the New Orleans Saints 18-17 on Sunday while the Lions defeated the Atlanta Falcons 20-6.
The Sunday Night Football matchup has the New York Jets hosting the Kansas City Chiefs. The Seattle Seahawks will travel to face the New York Giants on Monday Night Football.
Speaking of traveling, the Falcons and Jacksonville Jaguars will head overseas to play Sunday in the first of two NFL games in London this season.
NFL Week 4 Opening Odds
|Detroit Lions||-106||+1.5 (-120)||Over 45 (-110)|
|Green Bay Packers||-110||-1.5 (-102)||Under 45 (-110)|
|Atlanta Falcons||+126||+3 (-118)||Over 44.5 (-110)|
|Jacksonville Jaguars||-148||-3 (-104)||Under 45.5 (-110)|
|Miami Dolphins||+120||+2.5 (-104)||Over 53.5 (-105)|
|Buffalo Bills||-142||-2.5 (-118)||Under 53.5 (-115)|
|Minnesota Vikings||-146||-3 (-105)||Over 44 (-110)|
|Carolina Panthers||+124||+3 (-115)||Under 44 (-110)|
|Denver Broncos||-144||-3 (-104)||Over 45.5 (-110)|
|Chicago Bears||+122||+3 (-118)||Under 45.5 (-110)|
|Baltimore Ravens||-102||+1.5 (-115)||Over 42.5 (-110)|
|Cleveland Browns||+116||-1.5 (-105)||Under 42.5 (-110)|
|Pittsburgh Steelers||-166||-3.5 (-105)||Over 41 (-110)|
|Houston Texans||+140||+3.5 (-115)||Under 41 (-110)|
|Los Angeles Rams||-112||-1.5 (-102)||Over 45.5 (-110)|
|Indianapolis Colts||-104||+1.5 (-120)||Under 45.5 (-110)|
|Tampa Bay Buccaneers||+138||+3 (-110)||Over 40.5 (-110)|
|New Orleans Saints||-164||-3 (-110)||Under 40.5 (-110)|
|Washington Commanders||+275||+7 (-105)||Over 44.5 (-110)|
|Philadelphia Eagles||-340||+7 (-115)||Under 44.5 (-110)|
|Cincinnati Bengals||+110||+1 (-105)||Over 41.5 (-110)|
|Tennessee Titans||-130||-1 (-115)||Under 41.5 (-110)|
|Las Vegas Raiders||+168||+4.5 (-115)||Over 50.5 (-110)|
|Los Angeles Chargers||-200||-4.5 (-105)||Under 50.5 (-110)|
|New England Patriots||+250||+6.5 (-105)||Over 42 (-110)|
|Dallas Cowboys||-310||-6.5 (-115)||Under 42 (-110)|
|Arizona Cardinals||+610||+14 (-110)||Over 42 (-110)|
|San Francisco 49ers||-900||-14 (-110)||Under 42 (-110)|
|Kansas City Chiefs||-450||-8.5 (-115)||Over 43.5 (-105)|
|New York Jets||+350||+8.5 (-105)||Under 43.5 (-115)|
|Seattle Seahawks||-120||-1.5 (-110)||Over 45 (-115)|
|New York Giants||+102||+1.5 (-110)||Under 45 (-105)|
The San Francisco 49ers are Week 3’s biggest opening favorites at 14 points over the Arizona Cardinals. The smallest favorites are the Tennessee Titans by one point over the Cincinnati Bengals.
The Miami Dolphins vs Buffalo Bills’ total of 53.5 is the highest over/under. The lowest number is 40.5 for Tampa Bay Buccaneers vs New Orleans Saints.
Dolphins vs Bills Early Odds & Prediction
The Dolphins (3-0) will look to keep rolling when they visit the Bills (2-1) in an AFC East matchup at 1 p.m. ET Sunday at Highmark Stadium in Orchard Park, N.Y.
The Dolphins scored the most points by an NFL team since 1966 on Sunday when they routed the Denver Broncos 70-20 behind rookie De’Von Achane’s 203 rushing yards and Tua Tangovailoa’s four touchdown passes. Josh Allen passed for a touchdown, threw for a TD and the Bills forced five turnovers in dismantling the Washington Commanders 37-3.
— Miami Dolphins (@MiamiDolphins) September 24, 2023
The Bills have played much better since their sloppy loss to the Jets in Week 1. Look for Buffalo to rise to the occasion at home against the high-flying Dolphins.
Pick: Bills -2.5 (-118)
Ravens vs Browns Early Odds & Prediction
It will be a showdown for first place in the AFC North when the Baltimore Ravens (2-1) visit the Cleveland Browns (2-1) at 1 p.m. ET Sunday at Cleveland Browns Stadium.
Myles Garrett had 3.5 sacks and the Browns’ defense allowed just 94 yards Sunday in a 27-3 victory over the Titans. The Ravens lost to the Indianapolis Colts 22-19 in overtime despite quarterback Lamar Jackson rushing for 101 yards and two touchdowns.
— Cleveland Browns (@Browns) September 24, 2023
The Browns defense dominated Sunday but will have a much harder time stopping the mobile Jackson than they did Titans QB Ryan Tannehill.
Pick: Ravens +1.5 (-115)
Movement on the Line?
Based on Sunday’s results, the Dallas Cowboys being favored by 6.5 points at home over the New England Patriots seems just about right. The Patriots (1-2) got past the Jets 15-10 while the Cowboys (2-1) faceplanted in a 28-16 loss to the Cardinals.
However, don’t let the Week 3 results fool you. The Cowboys have a much better team, and this spread is likely to go up, especially with the Cowboys being a darling of bettors.
Pick: Cowboys -6.5 (-115)
Season Record: 4-5 (-1.5 units) ATS
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