NFL Odds and Betting Lines for Thanksgiving Day of Week 12

• Three NFL games will be played on Thanksgiving, including the Saints hosting the Bills in primetime
• The Bears visit the Lions on Thursday and the Cowboys play at home against the Raiders
• A look at the matchups and odds for all three games can be found below with predictions

Thanksgiving Day brings its usual daylong menu of NFL games.

The Chicago Bears (3-7) and Lions (0-9-1) begin the action Thursday by meeting at 12:30 ET at Ford Field in Detroit in a game that will be televised by Fox. The Bears are 3.5-point road favorites, which can be seen in the NFL odds, as they will be facing the Lions on Thanksgiving for the third time in four seasons.

At 4:30 pm ET, the Dallas Cowboys host the Las Vegas Raiders at AT&T Stadium in Arlington. The Cowboys are favored by seven points in a game that will be carried by CBS.

NBC has its annual Thanksgiving primetime game with the Buffalo Bills visiting the New Orleans Saints at 8:20 pm ET at the Caesars Superdome. The Bills are 4.5-point choices.

NFL Thanksgiving Day Odds

Odds as of November 23rd at FanDuel

Bears vs Lions

Both teams have quarterback questions.

The Bears’ Justin Fields left Sunday’s 16-13 loss to the Baltimore Ravens with a rib injury and did not return. Coach Matt Nagy had no definitive word on Fields’ status Monday and veteran Andy Dalton could step in as the starter.

Justin Fields dropping dimes, and we should not be surprised by it. pic.twitter.com/rFZhGvkccn

— Corey Seeley (@coreyalex) November 21, 2021

The Lions’ Jared Goff sat out Sunday with a strained oblique as the Lions lost to the Browns in Cleveland. Tim Boyle made his first career start, but Goff was able to throw Monday and could be ready to play Thursday.

The Bears are on a five-game losing streak, one short of matching the longest of Nagy’s four years as coach. Chicago dropped six in a row last season.

While the Lions are the NFL’s lone winless team, they are getting closer to victory. They lost by just three points, 13-10, to the Browns after tying the Pittsburgh Steelers 16-16 two weeks ago.

D’Andre Swift rushed for at least 130 yards in each game.

.@DandreSwift set his career high in rush yards…again

Up next: #CHIvsDET | 📺 FOX pic.twitter.com/hkWjnsaLU5

— Detroit Lions (@Lions) November 22, 2021

With the QB uncertainty, the over/under has dropped a point from the opening 42.5 number.

The Lions have lost on each on the last four Thanksgivings, twice to the Bears.

However, the Lions’ defense has been much better since the bye week, giving up 29 points in two games after allowing 30.5 points a game through the first eight weeks. Look for the defense to at least keep things close.

The Pick: Lions +3.5 (-110)

Raiders vs Cowboys

In a week with a lot of low point spreads, the Cowboys opened as seven-point favorites and the line has gone unchanged. The total of 51 has also held steady.

However, the Cowboys have a lot of injury concerns on offense.

Amari Cooper will miss a second straight game because of a positive COVID-19 test and fellow wide receiver CeeDee Lamb sustained a concussion Sunday in a loss to the Chiefs in Kansas City. Left tackle Tyron Smith (ankle) is likely to miss his fourth game in a row.

CeeDee Lamb is being evaluated for a concussion and will not return, via @MySportsUpdate

It is believed to have been suffered on this play. Cowboys are now without their top two WRs

(Via @nfl)pic.twitter.com/Y37XvZa92L

— Pickswise (@Pickswise) November 21, 2021

Running back Ezekiel Elliott is playing through a knee injury and has been limping during recent games. He has averaged just 3.2 yards a carry in the last two weeks after posting a 4.5 mark through the first eight games.

The Cowboys have lost two of their last three games, but the Raiders are struggling even more as they are on a three-game losing streak. Las Vegas has been outscored 96-43 during the skid by the New York Giants, Chiefs and Cincinnati Bengals.

Quarterback David Carr seemed headed to the Pro Bowl a month ago but has six turnovers in the last three games with four interceptions and two fumbles.

Hendrickson, Hubbard. Rinse, Repeat.

Watch on CBS pic.twitter.com/6T4TEMMnGV

— Cincinnati Bengals (@Bengals) November 21, 2021

Despite being banged up and having lost five times in the last seven Turkey Days, the Cowboys still should be able to handle the fading Raiders, especially at home.

The Pick: Cowboys -7 (-110)

Bills vs Saints

Both teams are fizzling as the calendar gets closer to December.

The Saints are on their first three-game losing streak since 2016 and the skid has come immediately after they had a chance to tie the Tampa Bay Buccaneers for the NFC South lead. The Bills have lost three of their five games to cede first place in the AFC East to the New England Patriots.

Jonathan Taylor has four touchdowns. He is very good. pic.twitter.com/OLxkojVrBW

— Barstool Sports (@barstoolsports) November 21, 2021

The Bills entered last week leading the NFL in total defense and the Saints were tops in run defense. However, both teams’ Ds got gashed Sunday.

The Colts’ Jonathan Taylor rushed for 185 yards and scored a franchise-record five touchdown to lead Indianapolis over the Bills 41-15. The Saints gave up 242 yards on the ground and three rushing touchdowns to quarterback Jalen Hurts in losing to the Philadelphia Eagles 40-29.

Jalen Hurts snatching ankles 🤧
pic.twitter.com/SJgWenKpUF

— PFF (@PFF) November 21, 2021

The line has moved from 3.5 to 4.5 as bettors are apparently concerned about the health of the Saints’ offense. Running back Alvin Kamara missed last week’s game along with tackles Terron Armstead and Ryan Ramczyk and all could sit out again Thursday.

The over/under has dropped one point to 46.5.

Both teams have had recent success on Thanksgiving. The Saints beat the Atlanta Falcons in 2018 and 2019 and the Bills knocked off the Cowboys two years ago.

Yet neither team inspires much confidence by their recent play. The lean here is to go with the Saints as the home dog.

The Pick: Saints +4.5 (-110)