Opening NFL Week 10 Odds – Point Spread, Moneyline & Total for All Games

• The Week 10 NFL odds have been released
• The Bengals and Ravens open Week 10 on Thursday Night Football
• See the opening NFL Week 10 odds (spread, moneyline, and total) for all 14 games

Another weekend of football is almost in the books and oddsmakers have already posted lines for next Sunday. NFL Week 10 starts with an AFC North clash between the Baltimore Ravens (6-3) and Cincinnati Bengals (4-5) on Thursday Night Football and culminates with the Miami Dolphins (2-6) vs Los Angeles Rams (3-4) on Monday. The other 12 games . The table below lists the opening odds – point spread, moneyline, and game total – for all 14 games on the docket.

Opening NFL Week 10 Odds

Four teams are on bye in Week 10: the Cleveland Browns, Green Bay Packers, Las Vegas Raiders, and Seattle Seahawks. 

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Biggest Week 10 Spread: Broncos vs Chiefs (-9.5)

The biggest spread in Week 10 is in the Denver Broncos (5-4) vs Kansas City Chiefs (7-0) matchup, where the still-unbeaten Chiefs are 9.5-point home favorites. No other spread is over 6.5.

The two-time defending Super Bowl-champion Chiefs remain the +450 favorites in the Super Bowl odds, well ahead of the Detroit Lions and Baltimore Ravens, who are tied for second at +650. While KC is undefeated straight-up this year, they are only 5-2 against the spread heading into a MNF game with Tampa Bay.

The Broncos, one of the surprise teams of the first half, are 6-3 ATS, which is the seventh-best cover rate in the league so far. Some of the sheen came off Denver in Week 9, however, when the Broncos were pasted 41-10 in Baltimore by the Ravens. Rookie QB Bo Nix was just 19-of-33 for 223 yards, no touchdowns, one interception, and four sacks.

Highest Week 10 Total: Dolphins vs Rams (50.5 O/U)

Just as the Broncos/Chiefs spread is three points greater than any other Week 10 line, the game total in Dolphins/Rams is two points higher than any other over/under. The Miami vs Detroit O/U has opened at 50.5, while the next-highest total on the board is Lions/Texans and 49ers/Buccaneers, both at 48.5.

Neither the Dolphins nor Rams have been played in particularly high-scoring games this season, overall. Miami is just 2-6 O/U while the Rams are 2-5 O/U. But both suffered from a rash of offensive injuries early in the year and both are trending towards being healthier.

For the Dolphins, the big absence was QB Tua Tagovailoa. But the oft-concussed Alabama product has now made it through two straight games unscathed, and Miami has put up 27 points in each.

Lowest Week 10 Total: Titans vs Chargers (37.5)

The lowest Week 10 total is in the Titans vs Chargers game in Los Angeles, which has opened with an O/U of just 37.5, one point lower than Patriots vs Bears.

The Chargers have managed to go 5-3 O/U this season without a single one of their games going over 40 points. Oddsmakers have been all over the defense-first Chargers from the jump.

The Titans have been the best under bet in the season so far, going 1-7 O/U. They have the second-worst scoring offense in the league (17.5 PPG) and a subpar-but-not-abhorrent defense (26.7 PPG).