San Francisco 49ers vs Buffalo Bills Prediction, Pick & Odds for Sunday Night Football

• We’ve made our San Francisco 49ers vs Buffalo Bills prediction for Sunday Night Football in Week 13
• The latest SF vs BUF odds favor the Bills by 6 points at home
• Read below for 49ers vs Bills prediction, odds and expert picks

The San Francisco 49ers (5-6) visit the red-hot Buffalo Bills (9-2) on Sunday Night Football in a Week 13 clash between early Super Bowl favorites now heading in opposite directions.

The Bills have won six straight, including an impressive 30-21 victory over Patrick Mahomes and the Chiefs before their Week 12 bye. Meanwhile, the injury-plagued Niners are reeling from back-to-back losses, mustering just 10 points in a 38-10 defeat at Green Bay — their worst loss under Kyle Shanahan.

Here’s our 49ers vs Bills prediction and the latest odds for Sunday Night Football.

San Francisco 49ers vs Buffalo Bills Odds

The San Francisco 49ers vs Buffalo Bills odds show Buffalo as 6-point home favorites, translating to a 69.2% implied probability. The Bills need to win by a touchdown or more to cover the spread.

This line opened with the Bills as 6.5-point favorites before ticking down to 6 at some sportsbooks. With the 49ers earning sharp money, the line movement indicates respected bettors believe San Francisco is undervalued. The total opened at 46.5 points and has steadily fallen to 44.5 due to concerns over potential winter weather impacting the offenses.

FANDUEL SPORTSBOOK

Offer

T&Cs

Bet $5 & Get $300 in Bonus Bets if Your Bet Wins

Must be 21+. T&C Apply. Gambling Problem? Call 1-800-GAMBLER.

LOCK IN PROMO

SIGNUP PROMO

BET $5
GET $300

BET NOW

Odds as of November 29, 2024 at FanDuel Sportsbook. Access the latest NFL betting odds here.

49ers Betting Outlook

Injuries have derailed the 49ers’ 2024 season, but Kyle Shanahan’s squad has remained competitive in the daunting NFC West. Despite losing Trent Williams and Nick Bosa, San Francisco still boasts the NFL’s 5th-ranked defense in yards allowed.

Kyle Shanahan on critics: “When it comes to grading myself, I’m not gonna grade myself. I’m gonna work as hard as I can. I’m the same guy right now that I’ve always been. We’ve gotta overcome some things that we’re in right now and I believe we can.” pic.twitter.com/QobkNukVnV

— 95.7 The Game (@957thegame) November 27, 2024

Quarterback Brock Purdy is expected to play after missing Week 12 with a shoulder injury. The 49ers managed just 10 points with journeyman Brandon Allen under center in a 38-10 loss to the Packers, their worst defeat under Shanahan. Getting Purdy back would provide a major boost to an offense averaging just 8.5 PPG over the last two weeks.

Star running back Christian McCaffrey returned from a foot injury in Week 10 but has yet to regain his All-Pro form. The dynamic playmaker has totaled just 149 rushing yards and 132 receiving yards without a touchdown in three games. Establishing the run and controlling the clock will be critical against Buffalo’s explosive offense.

Bills Betting Outlook

The Bills have been the NFL’s hottest team since mid-October, rattling off six straight victories. NFL MVP favorite Josh Allen has been magnificent, completing 64% of his passes for 2,543 yards and 18 touchdowns against just five interceptions.

Just Josh Allen doing Josh Allen things.@ECMCBuffalo | #BillsMafia pic.twitter.com/OkMQkJvHfF

— Buffalo Bills (@BuffaloBills) November 30, 2024

Buffalo’s offense ranks 3rd in scoring at 29.1 PPG and should get a boost with the returns of receivers Amari Cooper and Keon Coleman from injury. The Bills have scored 30+ points in all five home games this season.

Defensively, the Bills have been stout against the run, allowing just 119.1 yards per game (13th). They’ll need to contain McCaffrey and force Purdy to beat them through the air in potentially inclement weather. Buffalo’s secondary has been vulnerable at times, yielding 210 passing yards per game (12th).

49ers vs Bills Prediction

While the Bills have been rolling, I believe this spread is an overreaction to the 49ers’ blowout loss in Green Bay. San Francisco was missing several key starters in that game, including Purdy, Williams, and Bosa. With Purdy trending towards playing and the Niners getting healthier, I expect a much more competitive contest.

Furthermore, the 49ers have excelled in cold-weather games under Shanahan. In three night games with temperatures below 40 degrees, San Francisco has covered the spread each time as an underdog. With snow and freezing conditions in the forecast, the elements could help neutralize Buffalo’s passing attack.

The spread has already moved from 49ers +6.5 to +6 at some books, a sign that respected money is backing San Francisco. I’ll gladly take the points with a desperate 49ers squad in a tough environment. Shanahan is too good of a coach to let his team get blown out in back-to-back weeks.

While I don’t love either side of the total, the Under is enticing given the weather concerns and San Francisco’s offensive struggles. However, I’ll stick with the 49ers as my best bet to cover the inflated spread in a closer-than-expected game. Let’s back Jimmy G’s former squad to keep things competitive in Orchard Park.

SNF Picks & Prediction:

• 49ers +6 (-110)