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NFL Week 10 Odds – Opening Lines and Spreads for All Games

John Perrotto

by John Perrotto in NFL Football

Nov 7, 2021 · 6:19 PM PST

Jonathon Cooper and Caden Sterns celebration
Denver Broncos' Jonathon Cooper (53) and safety Caden Sterns (30) celebrate after Sterns intercepted a pass thrown by Dallas Cowboys' Dak Prescott in the second half of an NFL football game in Arlington, Texas, Sunday, Nov. 7, 2021. (AP Photo/Michael Ainsworth)
  • Week 10 of the NFL season begins Thursday night with the Ravens visiting the Dolphins
  • The Bills are the biggest opening favorites of the week at 13.5-points on the road over the Jets
  • All the Week 10 opening lines and spreads can be found below with analysis

Week 10 of the NFL season begins Thursday night with the Baltimore Ravens visiting the Miami Dolphins.

The Ravens have opened as 7-point favorites. Baltimore is 5-2 while the Dolphins are 2-7.

On Sunday Night Football, the Kansas City Chiefs (5-4) are 2.5-road favorites over the Las Vegas Raiders (5-3). The visiting Los Angeles Rams (7-1) are favored by 4.5 points over the San Francisco 49ers (3-5) on Monday Night Football.

Here is a look at all the NFL Week 10 lines:

NFL Week 10 Opening Odds

Team Moneyline Spread Over/Under
Baltimore Ravens -335 -7 (-110) Over 48.5 (-110)
Miami Dolphins +270 +7 (-110) Under 48.5 (-110)
Team Moneyline Spread Over/Under
Jacksonville Jaguars +410 +10 (-105) Over 48 (-110)
Indianapolis Colts -520 -10 (-115) Under 48 (-110)
Team Moneyline Spread Over/Under
Cleveland Browns +108 +2.5 (-110) Over 45.5 (-110)
New England Patriots -126 -2.5 (-110) Under 45.5 (-110)
Team Moneyline Spread Over/Under
Atlanta Falcons +360 +9.5 (-110) Over 51.5 (-110)
Dallas Cowboys -460 -9.5 (-110) Under 51.5 (-110)
Team Moneyline Spread Over/Under
Buffalo Bills -700 -13.5 (-105) Over 48.5 (-110)
New York Jets +500 +13.5 (-115) Under 48.5 (-110)
Team Moneyline Spread Over/Under
New Orleans Saints +130 +2.5 (-105) OFF
Tennessee Titans -152 -2.5 (-115) OFF
Team Moneyline Spread Over/Under
Tampa Bay Buccaneers -390 -8.5 (-110) Over 51.5 (-110)
Washington Football Team +310 +8.5 (-110) Under 51.5 (-110)
Team Moneyline Spread Over/Under
Detroit Lions +350 +8.5 (-110) Over 43 (-110)
Pittsburgh Steelers -450 -8.5 (-110) Under 43 (-110)
Team Moneyline Spread Over/Under
Minnesota Vikings +118 +2.5 (-105) Over 51.5 (-110)
Los Angeles Chargers -142 -2.5 (-115) Under 51. 5 (-110)
Team Moneyline Spread Over/Under
Carolina Panthers OFF OFF OFF
Arizona Cardinals OFF OFF OFF
Team Moneyline Spread Over/Under
Seattle Seahawks OFF OFF OFF
Green Bay Packers OFF OFF OFF
Team Moneyline Spread Over/Under
Philadelphia Eagles +110 +1.5 (-105) Over 44.5 (-114)
Denver Broncos -130 -1.5 (-115) Under 44.5 (-106)
Team Moneyline Spread Over/Under
Kansas City Chiefs -136 -2.5 (-115) Over 51 (-110)
Las Vegas Raiders +118 +2.5 (-105) Under 51 (-110)
Team Moneyline Spread Over/Under
Los Angeles Rams -210 -4.5 (-110) Over 48.5 (-110)
San Francisco 49ers +176 +4.5 (-110) Under 48.5 (-110)

Odds as of November 7th at FanDuel.



States: AZ, CO, PA, IN, TN, MI



Bills Big Faves Despite Bad Loss

Despite losing to the lowly Jaguars 9-6 on Sunday as a double-digit favorite in Jacksonville, the Buffalo Bills are the heaviest favorites on the opening lines for Week 10. The Bills (5-3) are 13.5-point road choices over the New York Jets (2-6).

Bills quarterback Josh Allen had a rough day against the Jaguars with three turnovers, including two in the second half. He had not had a second-half turnover all season.

He even got picked – by Josh Allen.

Allen completed 31 of 47 passes for 264 yards with two interceptions and a fumble. He was also sacked four times.

The Jets lost 45-30 to the Colts on Thursday night in Indianapolis. Third-string quarterback Josh Johnson threw for a career-high 317 yards, but it wasn’t enough.

Jets backup QB Mike White started in place of Zach Wilson (knee) then left the game in the second quarter with a hand injury.

Broncos Slim Picks over Eagles

The Denver Broncos are the slimmest favorites as 1.5-point picks at home over the Philadelphia Eagles.

The Broncos (5-4) pulled off a big upset Sunday when they defeated the NFC East-leading Dallas Cowboys 30-16 in Texas for their second straight win. Denver built a 30-0 lead then coasted to the finish line.

Rookie linebacker Jonaton Cooper had the first two sacks of his career. He moved into the starting lineup after Von Miller was traded to the Los Angeles Rams earlier in the week.

Teddy Bridgewater threw for a touchdown and had a sneak for another as the Broncos ended the Cowboys’ six-game winning streak.

The Eagles (3-5) lost to the Los Angeles Chargers 27-24 at home as Dustin Hopkins kicked a game-winning 29-yard field goal with two second remaining.

Rookie wide receiver DeVonta Smith had a big day for the Eagles as he caught five passes for 116 yards and a touchdown.

Jalen Hurts accounted for 214 yards of total offense. He was 11-of-17 passing for 162 yards and a TD and rushed for 62 yards on 10 carries.

Highs and Lows

Three games have a 51.5-point total, which is the highest on the board – Atlanta Falcons at Cowboys, Tampa Bay Buccaneers at Washington Football Team, and Minnesota Vikings at the Chargers.

The lowest over/under is 43 for the Detroit Lions’ visit to the Pittsburgh Steelers. The total has been under in five of the Steelers’ seven games this season, and five times in eight games involving the Lions.

Movement on the Line?

The Cowboys opened as 9.5-point favorites over the Falcons and the Steelers as 8.5-point choices over the Lions.

Look for both spreads to take an upward turn. The Cowboys and Steelers are bettors’ favorites, and are playing at home against teams they should beat handily.

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