NFL Week 15 Odds – Opening Lines and Spreads for All Games

• Kansas City visit the LA Chargers on Thursday night to open Week 15 of the NFL season
• The Cardinals are the week’s biggest opening favorites by 14 points over the Lions
• All the Week 15 opening lines can be found below with analysis

Week 15 of the NFL season opens with the Kansas City Chiefs visiting the Los Angeles Chargers on Thursday Night Football.

The Chiefs (9-4) are on a six-game winning streak and opened as three-point favorites. LA (8-5) will be coming off back-to-back wins.

There are two Saturday games this week with the Cleveland Browns (7-6) playing host to the Las Vegas Raiders (6-7) at First Energy Stadium as 5.5-point favorites and the New England Patriots (9-4) visiting the Indianapolis Colts (7-6) at Lucas Oil Stadium as one-point picks.

Sunday Night Football features the Tampa Bay Buccaneers (10-3) hosting the New Orleans Saints (6-7) at Raymond James Stadium. Tampa Bay are double-digit picks at 11.5 points.

The Minnesota Vikings (6-7) visit the Chicago Bears (4-8) on Monday Night Football at Soldier Field and are 4.5-point favorites.

Here is a look at all the opening NFL Week 15 odds and lines:

NFL Week 15 Opening Odds

Odds as of December 12th at FanDuel.

Cardinals Two-TD Picks over Lions

Arizona is the week’s biggest opening favorites at 14 points on the road over the Detroit Lions. It is a matchup between the teams with best and worst records in the NFL.

Detroit (1-11-1) followed their first win of the season by getting blown out by Broncos 38-10 on Sunday in Denver.

The Lions trailed just 17-10 at halftime but then lost a fumble on the second play of the third quarter. Shelby Harris punched the ball from Godwin Igwebuike’s grasp and Jonathon Cooper recovered at the Detroit 30.

.@ShelbyHarris93 forces it, @JonathonCooper7 recovers!

📺: FOX | #ProBowlVote pic.twitter.com/qcL54cDpF3

— Denver Broncos (@Broncos) December 12, 2021

Five plays later, Javonte Williams caught a 10-yard touchdown pass from Teddy Bridgewater, stretching the Broncos’ lead to two TDs and the Lions couldn’t recover.

The Cardinals (10-2) have won two games in a row and host the Los Angeles Rams on Monday Night Football.

Patriots Slight Favorites vs Colts

New England as one-point choices over the Colts on Saturday night is the the slimmest line of the week.

The Patriots have won seven straight games following a 2-4 start. They are tied with the Chiefs and Tennessee Titans for the top record in the AFC.

Joining the rookie record books. pic.twitter.com/kZKScr7LNq

— New England Patriots (@Patriots) December 11, 2021

Rookie quarterback Mac Jones has proven he does not get rattled on the road.

The Colts have won four of their last five games to move above .500.

Highs and Lows

Chiefs-Chargers is the highest opening total for Week 15, at 48.5 .

Kansas City rolled to a 48-9 victory over the Raiders on Sunday as Patrick Mahomes threw his first two touchdowns passes in almost a month. Clyde Edwards-Helaire rushed for two scores and Kansas City forced five turnovers.

FLASH. GORDON. 🔥

📺: #LVvsKC on CBS pic.twitter.com/TjmOXZdQR5

— Kansas City Chiefs (@Chiefs) December 12, 2021

Six of the Chiefs’ 13 games have gone over the total this season but just two of the last eight. LA’s 12 games have been split between over and under, though the over has been the winning side in three of the last four.

The 42.5 over/under for Raiders-Browns is the lowest of the week.

Strip Sack. Scoop and Score. History!

📺: #BALvsCLE on CBS
📲: Browns mobile app pic.twitter.com/950K5Az826

— Cleveland Browns (@Browns) December 12, 2021

Cleveland edged the Baltimore Ravens 24-22 on Sunday as Baker Mayfield threw two touchdown passes and Myles Garrett scored his first career TD.

Six of the Browns’ 13 games have gone under while seven of the Raiders’ 13 games have gone under, including two of the last three.

Movement on the Line?

The rationale in the Green Bay Packers opening as 6.5-point favorites over the Ravens in Baltimore is easy enough to understand, Ravens quarterback Lamar Jackson left Sunday’s game with an ankle injury.

However, look for the bettors to jump on the Ravens getting that many points at home, regardless of the QB situation.

Another line that seems a big high is the Dallas Cowboys being 11.5-point road picks over the New York Giants, While the Giants’ quarterback situation in flux, Big Blue getting double-digit points at home figures to get jumped on by the sharps in New York and New Jersey.