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Week 2 NFL Picks Against the Spread – Early Lines to Target

Robert Duff

by Robert Duff in NFL Football

Updated Sep 11, 2023 · 1:22 PM PDT

Detroit Lions are favored at home agains Seattle Seahawks in NFL Week 2 picks against the spread
Detroit Lions quarterback Jared Goff (16) talks to head coach Dan Campbell before a play against Kansas City Chiefs during the second half at Arrowhead Stadium in Kansas City, Mo. on Thursday, Sept. 7, 2023.
  • In the Week 2 NFL picks against the spread, the Buffalo Bills are 9.5-point home favorites over the Las Vegas Raiders
  • The Detroit Lions are a 4.5-point home pick over the Seattle Seahawks
  • After recording a divisional win over Cincinnati, the Cleveland Browns are set as 1.5-point road favorites at the Pittsburgh Steelers

Assessing the early lines to target in the Week 2 NFL picks against the spread, there’s two games that are offering betting lines of significance. At Ford Field, the 1-0 Detroit Lions are 4.5-point home favorites over the Seattle Seahawks. It’s just the sixth time in 34 games that the Lions are the betting chalk.

Meanwhile, the Cleveland Browns are going to Pittsburgh as road favorites over the Steelers. The Browns are 1-19 straight up in their last 20 games at Pittsburgh.

Are any of these teams worth a wager in the NFL odds as Week 2 ATS picks? Let’s check out the possibilities.

Week 2 NFL Picks Against the Spread

Matchup Spread Pick Units Risked
Detroit Lions vs Seattle Seahawks DET-4.5 DET 1
Las Vegas Raiders vs Buffalo Bills BUF-9.5 LVR 1
Pittsburgh Steelers vs Cleveland Browns CLE-2.5 CLE 1

Our top NFL ATS picks this week in the table above will feature plays on the Lions, Raiders and Browns.

Odds as of September 11 at BetMGM Sportsbook. Get this BetMGM promo code to bet on the NFL. For bettors in Kentucky, head over to BetMGM Kentucky to claim your pre-registration bonus as Kentucky sports betting gets set to launch on September 28.

NFL ATS Pick 1: Lions Winning Over Oddsmakers

Winning last week as a road underdog at Kansas City, this is the second year in a row that Detroit is set as an early-season home favorite against Seattle. It didn’t turn out well for the Lions last season. In Week 4, Detroit fell 48-45 to the Seahawks as the 3.5-point home chalk.

However, the times are changing for Detroit. This is the fourth successive home game in which the Lions are favored. They’re 3-0 ATS in the previous three games.

ATS Picks: Detroit Lions -4.5 (-110), 1 unit

NFL ATS Pick 2: Bills Struggle As Heavy Chalk

For starters, the Buffalo Bills are coming home to face the 1-0 Las Vegas Raiders on a short week following Monday’s road game against the New York Jets. Buffalo was 0-1 ATS with a rest disadvantage last season.

Secondly, the Bills are opening as 9.5-point home favorites over the Raiders. Buffalo has failed to cover as a favorite of 9.5 points or more in five successive games. That includes the club’s last three home games.

ATS Picks: Las Vegas Raiders +9.5 (-110), 1 unit

NFL ATS Pick 3: Browns to Win At Pittsburgh?

The Cincinnati Bengals are favorites to win the AFC North in the NFL Divisional odds. However, thanks to the Cleveland Browns, the Bengals are 0-1 on the 2023 NFL season.

That game was in Cleveland. In Week 2, the Browns are heading into what for them has proven to be the abyss. They are 1-19 SU and 2-6 ATS at Pittsburgh. Yet the opening line is Cleveland -1.5. It’s the first time since 1989 that the Browns are favored in Pittsburgh.

Every Steelers player not named TJ Watt should be hanging their head in shame following their Week 1 embarrassment, a 30-7 home loss to San Francisco. It’s going to be much worse after the Browns leave the Steel City with a rare victory.

ATS Picks: Cleveland Browns +1.5 (-110), 1 unit

  • ATS season record 0-2-0

Week 2 NFL Picks Against the Spread Quick Picks

  • Eagles (-7.5) vs Vikings: Philadelphia whipped Minnesota 24-7 last season at Lincoln Financial Field. Eagles are 9-2 ATS at home in the last 11 games vs Vikings
  • Chargers (-2.5) vs Titans: Justin Herbert and LA rebound from heartbreaking Week 1 loss to Miami. Chargers are 12-2 SU in last 14 vs Titans
  • Packers (-1) vs Falcons: Jordan Love may not conquer all, but he’ll beat the Falcons on the road. Packers are 5-1 ATS in the last six games
  • Colts (-1.5) vs Texans: Battle of rookie QBs goes to Indy’s Anthony Richardson. Colts are 7-3 ATS in last 10 vs Texans
  • Bears (+2.5) vs Buccaneers: Chicago is 1-8 ATS in the last nine games, but Tampa Bay is 2-8-1 in the last 11 home games
  • Jaguars (+3) vs Chiefs: Jacksonville gave Kansas City fits in last season’s NFL playoffs
  • Bengals (-3) vs Ravens: Cincinnati has won seven in a row at home and four of the last five against Baltimore
  • Giants (-5) vs Cardinals: Arizona was 1-7 straight up at home last season
  • Cowboys (-3) vs Jets: Seeking the New York sweep, Dallas is 5-0 SU over the club’s last five home games
  • Commanders (+3.5) vs Broncos: Washington is 5-2 ATS in the last seven games at Denver
  • Dolphins (-2) vs Patriots: Miami is 5-0 ATS in the last five games at New England
  • Saints (-2.5) vs Panthers: New Orleans is 5-0-1 ATS in last six games facing Panthers

 

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