Premier League Matchday 3 Odds & Picks: Manchester City vs Arsenal, Wolves vs Manchester United & More

• Manchester City and Arsenal get Matchday 3 of the 2021/22 Premier League season underway on Saturday
• They are followed by several big matches, including Wolves vs Manchester United on Sunday
• Read below for the latest Premier League odds, previews and tips

Matchday 3 of the 2021/22 Premier League campaign is upon us. Manchester City host Arsenal to lead off the weekend ahead of five fixtures kicking off at 10:00 am ET. Aston Villa vs Brentford is the pick of those five before Liverpool welcome Chelsea in the last Saturday match.

Treated to three matches on Sunday, there’s a clash of footballing philosophy as Leeds travel east to Burnley. Nuno Espirito Santo looks to continue his strong start as Spurs manager as the north London club face newly promoted Watford. To wrap up the weekend, Manchester United head south to take on a Wolves side which hasn’t scored in its first two matches.

Premier League Matchday 3 Odds

Odds as of Aug 27 at DraftKings

Manchester City vs Arsenal Prediction

Although without Kevin De Bruyne and Phil Foden, Manchester City are still comfortable favorites for the visit of Arsenal on Premier League Matchday 3. The Gunners have lost both of their matches to nil so far this season, and have their own selection issues. Pierre-Emerick Aubameyang should return to the starting lineup after a hat-trick in midweek, but Thomas Partey, Ben White and Gabriel remain on the sidelines. Kieran Tierney and Bukayo Saka are both doubts.

City have won their last five against Arsenal at the Etihad. Their search for a striker continues, but the attack was in fine form as they thumped Norwich 5-0 last weekend. There are rumors about Raheem Sterling’s future, but he’s expected to start down the middle on Saturday. Coming off a goal against the Canaries and a brilliant Euros campaign, he’s a good bet to score anytime at +150.

Man City could offload Raheem Sterling to fund a Cristiano Ronaldo purchase, according to the Gazzetta dello Sport.

Would they regret letting him leave? 👋 pic.twitter.com/zfjaDqLo42

— Goal (@goal) August 27, 2021

The hosts will control this one from start to finish. Aubameyang has troubled City’s high line in the past, which will put some bettors off City winning to nil at +100. It should still be a one-sided match, though, which makes City to win both halves a good bet.

Pick: City to win both halves (+170)

Aston Villa vs Brentford Prediction

Leon Bailey, Ollie Watkins Trezeguet and Bertrand Traore are out for the hosts. The Villains thrashed Barrow in the Carabao Cup in midweek, following on from a 2-0 win against Newcastle last weekend. They face a Brentford side yet to concede in the Premier League, and who have a settled starting lineup. Thomas Frank will likely name the same XI for the third straight league match.

Crystal Palace had 2 shots on target vs. Brentford — just 1 of which was from inside the penalty area.

2/2 clean sheets for Thomas Frank’s side. 🐝 pic.twitter.com/MYMv2FdGa7

— Statman Dave (@StatmanDave) August 21, 2021

Brentford have been incredibly impressive in their two matches so far. They are just seventh in expected goals against. Aston Villa are fifth by the same metric.

Of course, we’re dealing with tiny sample sizes, but the defensive stability of the Bees should not be downplayed. With Villa missing key attacking talent, they could struggle to create chances. Dean Smith’s team have generated just 2.2 expected goals thus far.

"It's great to get the three points, especially in front of our own fans." 💜

Dean Smith's thoughts following Aston Villa 2-0 Newcastle. 🗣️ pic.twitter.com/QYgvFbd4EK

— Aston Villa (@AVFCOfficial) August 21, 2021

Under 2.5 goals carries some value at -115. Villa were involved in a five-goal encounter with Watford in their season opener, though, which suggests it’s best to look elsewhere. The return of fans has boosted home advantage, but with important absences, and with how solid Brentford have looked, the visitors to avoid defeat looks a solid option here.

Pick: Brentford or draw (-120)

Wolves vs Manchester United Prediction

Manchester United are unbeaten in 27 Premier League away matches. Ole Gunnar Solskjaer’s side are coming off a meek performance against Southampton last time out, though they could welcome Raphael Varane and Jadon Sancho into the starting XI at Molineux.

This window started on a high with Sancho & Varane signings but could have a very sad ending with Cristiano Ronaldo joining Man City and Man United not getting a new midfielder. Pain.

— UtdFaithfuls (@UtdFaithfuls) August 26, 2021

Consecutive 1-0 defeats to start to the season hasn’t exactly inspired confidence in Wolves. The return of Daniel Podence in midweek gives Bruno Lage another useful attacking option, but this match is more likely to be a challenge of their defense. It will be a familiar pattern to this fixture with Manchester United dominating possession throughout. This will be a real test of the Red Devils’ ability to break down a low block.

Just five goals have been scored in the last five meetings between these two sides. Three of those came in their matchup at the end of last season. Wolves’ defensive approach and Manchester United’s uninspiring attacking performance against Southampton suggests another low-scoring affair on Premier League Matchday 3.

Pick: Under 2.5 goals (-120)