Predictions & Betting Lines for Potapova vs Anisimova

• Amanda Anisimova is a monster -600 favorite vs Anastasia Potapovin in Round 3 women’s singles action at the US Open
• Anisimova’s elite top-10 ranking provides a decisive edge as the two players will meet for the first time
• See my Potapova vs Anisimova predictions, along with the latest betting lines below

It’s a Round of 32 clash that presents a massive rankings gap, as Amanda Anisimova finds herself as a massive betting favorite against Anastasia Potapova.

The biggest matchup question for bettors is whether Anisimova’s top-tier pedigree will override Potapova’s sturdy form this season.

Anisimova wields a ridiculous 2,777-point advantage in standard rankings. However, the 2026 WTA Race paints a tighter picture, separating them by merely three spots. Figuring out which metric carries more weight is how I plan to unlock betting value today.

This match gets going Saturday morning at 11am ET from Louis Armstrong Stadium at the USTA Billie Jean King National Tennis Center in Flushing Meadows, New York.

Catch the action on ESPN2 in the United States or tune into TSN if you’re in Canada.

Potapova vs Anisimova Predictions

• Pick: Anisimova to Win 2-0 (-170 at Kalshi)

Sportsbooks set Anisimova’s moneyline price at -602, a number too steep to justify laying the favorite outright. The better angle is the exact-set market: back Anisimova to sweep 2-0 at -178.

The matchup data supports Anisimova’s superiority, particularly on hard courts. Tennis Abstract’s Aug. 31 Elo ratings place Anisimova at 1,950.5 overall and 1,913.2 on hard courts, compared with Potapova at 1,867.3 overall and 1,778.5 on hard courts. That 134.7-point hard-court Elo gap is meaningful, and it aligns with Anisimova’s recent results: she has won her first two US Open matches and went 4-1 in Cincinnati, including victories over Linda Noskova and Alexandra Eala.

The 52-week numbers from Tennis Ratio reinforce the same edge. Anisimova owns the better dominance ratio (1.238 to 1.017), match efficiency (1.904 to 1.573), first-serve accuracy (63.9% to 55.8%), service-games-won rate (73.8% to 64.2%) and second-serve points won (48.0% to 43.8%). Potapova’s recent US Open wins show that she can compete, but Anisimova’s stronger serve and more efficient point production should allow her to control the baseline and close this in straight sets.

• Pick: Over 19.5 Total Games (-125 at bet365)

Anisimova remains the preferred winner, but Potapova’s form makes a low total dangerous. She has also won her opening two US Open matches, including a three-set victory over Leolia Jeanjean, and her 53.3% tiebreak-win rate gives her a path to extending a set if the match reaches a pressure finish.

Anisimova’s 2-0 projection does not require a blowout: a 6-4, 6-4 result clears 19.5 games. Potapova creates slightly more break points (0.85 per game to 0.78) and wins more return games (39.8% to 39.6%), while Anisimova’s superior serving and efficiency point to competitive holds rather than a runaway. The preferred combination is Anisimova in straight sets and Over 19.5 total games.

Potapova vs Anisimova Odds

Odds as of Sept 5 at bet365. Get a bet365 bonus code to wager on all tennis matches.

Amanda Anisimova steps onto the court as a heavy betting favorite. You have to lay a hefty -600 on the moneyline to back her outright. Expecting a controlled match, oddsmakers assigned Anisimova a sturdy 5.5-game spread advantage over Potapova.

The total games market sits at 19.5, with slight juice leaning toward the over at -125. If you believe the underdog can light the lamp, dictate the baseline, and pull off an outright upset, you can grab Potapova on the moneyline at a lucrative +400 payout.