Giants vs Cubs Picks, Predictions & Betting Splits (June 5)

• The San Francisco Giants look for a sixth straight win over the Chicago Cubs when they open a set Friday
• Chicago has just four wins in its last 18 games
• Read below for the my Giants vs Cubs prediction, picks updated odds and betting splits

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The Chicago Cubs (32-30) return to Wrigley Field as home favorites Friday to open a fresh series against the San Francisco Giants (25-38).

The Cubbies are -165 moneyline favorites in the MLB odds, despite the fact they’ve won just four of their last 18 games, and the Giants have won five straight in this head-to-head matchup.

First pitch goes at 2:20pm ET from Wrigley Field in Chicago, with MLB TV providing the broadcast coverage.

Giants vs Cubs Prediction

• Best Bet: Cubs ML (-160 at bet365)

Despite Chicago’s alarming losing trends overall and to San Francs=isco, when analyzing this matchup, the disparity in the MLB probable pitchers leads me directly to the home side.

Starting for the Cubs, Edward Cabrera enters with a 4.00 ERA and 7.83 K/9.

Cabrera has been a reliable presence in the rotation, boasting a solid 7-3 record across his 10 starts. His 1.35 WHIP demonstrates an ability to limit excessive damage, while his 3.33 BB/9 highlights sustainable command. He does not overwhelm hitters with strikeouts, but his steady efficiency allows him to average 5.40 innings per outing.

He is backed by a highly effective bullpen boasting a 3.38 collective ERA.

On the other side, Giants starter Robbie Ray has experienced a turbulent campaign. Ray brings higher strikeout upside but continuously struggles with traffic on the basepaths. Looking at his last 10 games, his struggles have magnified.

Ray is surrendering free passes at an alarming rate of 4.85 walks per nine innings, making it hard for him to limit traffic, leading to a 4.45 ERA and a 1.40 WHIP. He has also given up 1.90 home runs per nine over that span.

The Giants have won just 39.5% of their games when priced as the underdog this season (15-23).

Given the 4.25 bullpen ERA of the Giants and their over-reliance on contact hitting, I see immense value on the home favorite.

SF Giants vs CHI Cubs Expert Picks

O/U Pick: Under 11.0 Runs (-115 at BetMGM)
For the game total, both starting pitchers possess swing-and-miss ability. The reliable bullpen of the Cubs is well-equipped to suppress any late-inning rallies.

Luis Arraez Over 1.5 hits (+131 at DraftKings)
He is hitting .325 and averaging 1.26 hits per game. Because the Giants rely entirely on stringing base hits together, his involvement is highly probable.

Giants vs Cubs Odds & Betting Splits

The graphic above shows the best available odds, which are subject to change. Be sure to use the BetMGM promo code to bet on Giants vs Cubs or any other MLB game.

The Cubs enter this matchup as clear -158 moneyline favorites on their home diamond, with odds from at FanDuel. For bettors looking to back the favored side on the runline, taking them to win by two or more runs offers lucrative plus-money value at +120. Backing the underdog with the 1.5-run cushion requires laying -135 juice at bet365.

The opening total was initially set at 11.5 runs , which you can still get at FanDuel, while that number has come down to 11 runs at BetMGM, and pays out at -105 odds.

When checking the MLB public betting splits, the public and the larger bankrolls are in lockstep. The Cubs are dominating the moneyline market, commanding 78% of the tickets and 59% of the overall handle.

Confidence extends dramatically into the runline market. While 74% of tickets back the Cubs -1.5, a massive 90% of the total stake is riding on them to cover. This handle percentage indicates that larger wagers are heavily invested in a multi-run victory.

Unlike the side markets, the total has created a divided board, with the money split at an equal 50% at the 11.0 run total. The Over has 52% of the bets.