Final Ohio State vs Indiana Prediction, Best Bets & Updated Odds (Oct. 17)

• Unbeaten Indiana hosts Ohio State in a high-stakes Big Ten showdown.
• Turnover margin, run defense and DraftKings betting splits shape the angles.
• Read below for our Ohio State vs Indiana prediction, best bets and updated odds.

Ohio State visits unbeaten Indiana on Saturday, October 17, at noon ET on FOX. Memorial Stadium hosts two highly ranked Big Ten teams, with the 5-1 Buckeyes looking to hand the 6-0 Hoosiers their first loss.

The Ohio State vs Indiana odds on Kalshi point to a close game, with the Buckeyes a slight road favorite. A short number like that for a program with Ohio State’s pedigree makes the spread and total worth a close look.

Plenty is riding on the result in the Big Ten race and the wider college football futures market. Here is how we see the matchup, plus our top picks for Saturday.

Jump to: Ohio State vs Indiana Prediction | Ohio State vs Indiana Best Bets | Ohio State vs Indiana Odds | Betting Splits

Ohio State vs Indiana Prediction

• Pick: Indiana +3.5 (56¢ on Kalshi)

Prediction Markets

Indiana +3.5 vs Ohio State

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Kalshi

Indiana +3.5

56%

Predict

Indiana +3.5 is our Ohio State vs Indiana prediction. On Kalshi, this is the NO side of the Ohio State -3.5 contract, so it pays as long as the Buckeyes don’t win by four or more. At 56¢, that works out to roughly -127 before fees.

Indiana’s 6-0 start and 22-game win streak are built on ball security. The Hoosiers have tied or won the turnover battle in 30 straight games, and Josh Hoover has thrown 159 straight passes without an interception. That limits the short fields that turn close games into blowouts.

Ohio State’s pass rush has also cooled, with its pressure rate falling from 37.4% in 2025 to 25.9% this season. Add an Indiana run defense allowing 78.3 yards per game since 2024, compared to 89.7 for Ohio State, and the Hoosiers have a real path to cover even if the Buckeyes win.

Ohio State vs Indiana Best Bets

• Pick: Over 50.5 (50¢ on Kalshi)

Prediction Markets

Ohio State vs Indiana Over 50.5

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Kalshi

Over 50.5 points

50%

Predict

Our second Ohio State vs Indiana best bet is the Over. At 50¢, the price is about even money before fees. Ohio State has allowed just 11.4 points per game since 2023, but Indiana is a tougher test than most of the offenses behind that number.

Turbo Richard (597 yards) and Lee Beebe Jr. (551) lead the Indiana ground game, while Charlie Becker (529 receiving yards) and Nick Marsh (528) stretch the field. That balance puts pressure on Ohio State’s safeties and creates chances for big plays.

Jeremiah Smith is the top game-breaker on the other side. He has 916 receiving yards this season and needs 84 more for his third 1,000-yard campaign. With 3,474 career receiving yards and 38 touchdowns, he can score from anywhere. We like Indiana to stay within the number while both offenses push the total late.

Kalshi availability varies by state, so check where Kalshi is legal before trading.

Updated Ohio State vs Indiana Odds

Prices as of October 17, 2026, from Kalshi. New users can review the Kalshi promo code offer.

These are Kalshi contract prices, not sportsbook odds. Each contract pays $1 if it hits, so the price roughly reflects the market’s win probability. Ohio State’s 59¢ moneyline gives the Buckeyes about a 59% chance to win, while Indiana sits at 42¢. Fees and contract rules can affect final returns.

Ohio State vs Indiana Betting Splits

DraftKings betting splits show Ohio State drawing 67% of spread tickets and 79% of spread handle at -3. Indiana has 33% of tickets and 21% of handle at +3. Those numbers reflect DraftKings activity only, not Kalshi pricing.

The total is more divided. The Over has 56% of tickets but just 39% of handle, while the Under holds 44% of tickets and 61% of handle. More money has come in on the Under at DraftKings, even though we prefer the Over at 50¢. You can track more college football public betting trends before kickoff.

Ohio State vs Indiana Game Info

• Date: Saturday, October 17, 2026
• Kickoff: Noon ET
• TV: FOX
• Venue: Memorial Stadium, Bloomington, Indiana
• Records: Ohio State 5-1, Indiana 6-0