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Opening Week 9 College Football Odds, Spreads & Lines: Ohio State vs USC & More

Brady Trettenero

By Brady Trettenero in College Football

Published:


Ohio State receiver Jeremiah Smith carries the ball against Indiana ahead of the Buckeyesโ€™ Week 9 game at USC
Ohio State wide receiver Jeremiah Smith runs past Indiana defensive back Jamari Sharpe on Oct. 17, 2026, in Bloomington, Indiana. Credit: USA TODAY Network via Reuters Connect.
  • Ohio State is favored by a touchdown at USC in the early Week 9 college football odds
  • Miami is laying more than two touchdowns at North Carolina after a 52-23 win
  • See the early Week 9 odds, spreads and lines for all matchups below

Ohio State vs USC leads the opening Week 9 college football odds, with the Buckeyes favored by seven in Saturday’s 7:30 pm ET matchup on NBC. Ohio State heads to Los Angeles at 6-1, but Julian Sayin’s injury leaves a quarterback decision hanging over this Big Ten game.

Florida vs Georgia brings another major rivalry to the Week 9 schedule, this time at Mercedes-Benz Stadium in Atlanta at 3:30 pm ET on ABC. Miami visits North Carolina in primetime, while Wisconsin at Iowa opens the day at noon ET on FOX.

The table below has the early Week 9 spreads, totals and moneylines for all matchups listed. Check back for updated college football odds as the rest of the board fills in.

Opening Week 9 College Football Odds

MatchupSpreadTotalMoneyline
Delaware at Western Kentucky (Oct. 27)DEL -2.5 (-110) / WKU +2.5 (-110)O 58.5 (-110) / U 58.5 (-110)-135 / +114
Sam Houston at Missouri State (Oct. 27)SHSU +6.5 (-110) / MOST -6.5 (-110)O 51.5 (-110) / U 51.5 (-110)+185 / -225
Kennesaw State at Middle Tennessee (Oct. 28)KENN +2.5 (-105) / MTSU -2.5 (-115)O 48.5 (-115) / U 48.5 (-105)+114 / -135
Jacksonville State at New Mexico State (Oct. 28)JVST -3 (-110) / NMSU +3 (-110)O 50.5 (-110) / U 50.5 (-110)-142 / +120
Troy at James Madison (Oct. 29)TROY +17.5 (-110) / JMU -17.5 (-110)O 52.5 (-110) / U 52.5 (-110)+550 / -800
FAU at North Texas (Oct. 29)FAU +12.5 (-110) / UNT -12.5 (-110)O 69.5 (-110) / U 69.5 (-110)+360 / -470
Tulane at Charlotte (Oct. 30)TULN -13.5 (-110) / CLT +13.5 (-110)O 45.5 (-110) / U 45.5 (-110)-535 / +400
Baylor at UCF (Oct. 30)BAY +2.5 (-115) / UCF -2.5 (-105)O 48.5 (-110) / U 48.5 (-110)+102 / -122
Kent State at Sacramento State (Oct. 30)KENT -10 (-110) / SAC +10 (-110)O 46.5 (-110) / U 46.5 (-110)-380 / +300
Florida vs Georgia (Oct. 31)FLA +10.5 (-115) / UGA -10.5 (-105)O 56.5 (-110) / U 56.5 (-110)+330 / -425
Ohio State at USC (Oct. 31)OSU -7 (-105) / USC +7 (-115)O 52.5 (-110) / U 52.5 (-110)-250 / +205
Northwestern at Oregon (Oct. 31)NW +4.5 (-110) / ORE -4.5 (-110)O 51.5 (-110) / U 51.5 (-110)+150 / -180
Clemson at Florida State (Oct. 31)CLEM +5.5 (-115) / FSU -5.5 (-105)O 50.5 (-110) / U 50.5 (-110)+164 / -198
Auburn at Ole Miss (Oct. 31)AUB +11.5 (-110) / MISS -11.5 (-110)O 55.5 (-110) / U 55.5 (-110)+330 / -425
Arizona State at BYU (Oct. 31)ASU +14.5 (-105) / BYU -14.5 (-115)O 51.5 (-110) / U 51.5 (-110)+440 / -600
Mississippi State at Texas (Oct. 31)MSST +19.5 (-110) / TEX -19.5 (-110)O 51.5 (-110) / U 51.5 (-110)+700 / -1100
Notre Dame vs Navy (Oct. 31)ND -30.5 (-110) / NAVY +30.5 (-110)O 52.5 (-110) / U 52.5 (-110)-9000 / +2500
Arizona at Texas Tech (Oct. 31)ARIZ +4.5 (-115) / TTU -4.5 (-105)O 55.5 (-110) / U 55.5 (-110)+145 / -175
Wisconsin at Iowa (Oct. 31)WIS +3.5 (-105) / IOWA -3.5 (-115)O 39.5 (-110) / U 39.5 (-110)+145 / -175
SMU at Syracuse (Oct. 31)SMU -10.5 (-115) / CUSE +10.5 (-105)O 55.5 (-110) / U 55.5 (-110)-410 / +320
Miami at North Carolina (Oct. 31)MIA -16.5 (-110) / UNC +16.5 (-110)O 50.5 (-110) / U 50.5 (-110)-800 / +550
Missouri at Arkansas (Oct. 31)MIZ -11.5 (-105) / ARK +11.5 (-115)O 47.5 (-118) / U 47.5 (-102)-380 / +300
Washington at Nebraska (Oct. 31)WASH +9.5 (-115) / NEB -9.5 (-105)O 49.5 (-108) / U 49.5 (-112)+260 / -325

Early Week 9 odds from DraftKings, late Oct. 24. These are early prices and can move. Get the best prices with our College Football betting apps.

The spreads stretch from Baylor at UCF, a 2.5-point game, to Notre Dame laying 30.5 on Navy at Gillette Stadium in Foxborough. That one is a neutral-site game, same as Florida vs Georgia. Wisconsin at Iowa has the lowest total on the board at 39.5, while FAU at North Texas sits highest at 69.5.

Arizona at Texas Tech also shifted during the evening. An earlier look at the same board had the Red Raiders at -7.5 with a 53.5 total, while the latest board has Texas Tech at -4.5 and the total at 55.5, a three-point shift in the spread and two points in the total.

Ohio State vs USC Odds

The Ohio State vs USC odds are now available: the Buckeyes are favored by seven with a 52.5 total. Ohio State is -250 and USC is +205. Kickoff is 7:30 pm ET on NBC.

The quarterback situation is the reason to keep watching. Julian Sayin is out indefinitely with an injury to his throwing arm, and as of Friday, Oct. 23, Ryan Day had Luke Fahey and Tavien St. Clair competing without a starter named. Fahey is 9 of 13 for 203 yards with two touchdowns and two interceptions this season.

Ohio State is 6-1 and 4-0 off a bye after winning 19-15 at Indiana. USC is 6-2 and 3-2 following a 24-7 loss at Wisconsin, so both teams arrive with something to sort out.

Florida vs Georgia Spread

The Florida vs Georgia spread has the Bulldogs at -10.5 with a 56.5 total, Georgia at -425 and Florida at +330. Both teams were off on Oct. 24.

Florida is 5-2 and 3-2 in the SEC after beating Texas 27-24 on Oct. 17, a game the Gators trailed 17-3. Tramell Jones Jr. threw touchdown passes of seven and eight yards to Lacota Dippre, and the defense held Texas to 272 total yards and 99 on the ground before forcing a late Arch Manning fumble.

Georgia is 6-1 and 4-1, but its last time out was a 27-24 loss to Auburn. Laying 10.5 asks the Bulldogs to win by 11 against a team coming off a road upset, and Aaron Philo’s availability has not been confirmed, so the Florida quarterback situation is worth tracking through the week.

Miami vs North Carolina Line

The Miami vs North Carolina odds have the Hurricanes laying 16.5 with a 50.5 total. Miami is -800 and the Tar Heels are +550 at 7:30 pm ET, with the network still listed as ABC or ESPN.

Miami is 7-0 and 5-0 in the ACC after a 52-23 win over Pitt. Darian Mensah went 31 of 37 for 387 yards and four touchdowns, and Malachi Toney caught 16 passes for 194 yards and three scores.

North Carolina fell to 4-3 and 2-2 with a 31-30 overtime loss to Syracuse, a game in which it allowed a 76-yard touchdown pass in the fourth quarter. Those explosive plays are a concern against a Miami passing attack that just produced four touchdowns.

Wisconsin vs Iowa Odds

The Wisconsin vs Iowa odds have the Hawkeyes favored by 3.5 at home with that 39.5 total, the lowest posted this week. Iowa is -175 and Wisconsin is +145.

Wisconsin is 5-2 and 3-1 off the USC win, where it picked up two interceptions and five sacks and held the Trojans to minus-17 rushing yards. Sack yardage counts against rushing in college, which accounts for a chunk of that figure. Colton Joseph went 12 of 14 for 58 yards for the Badgers.

Iowa is 5-2 and 2-2 after a 13-10 loss at Minnesota. The Hawkeyes outgained the Gophers 288 to 209 and held them to 2 of 15 on third down with 10 tackles for loss and three sacks, but four turnovers decided it. Hank Brown threw for 136 yards and Jeremy Hecklinski added 62.

The half point past three matters in a game priced this low. At -3.5, a field-goal win does not cover for Iowa.

Other Notable Week 9 CFB Odds & Spreads

The midweek schedule starts Tuesday with Delaware at Western Kentucky and continues through Friday before Saturday’s games. The rest of that Saturday board includes SMU laying 10.5 at Syracuse, Missouri at -11.5 in Fayetteville and Nebraska favored by 9.5 over Washington.

On the shorter numbers especially, it is worth comparing the spread and the juice at sportsbooks against prediction market apps.

Brady Trettenero
Brady Trettenero

Lead NHL & NCAAF Editor

Brady is the lead NHL and College Football editor at Sports Betting Dime, where he specializes in betting odds and data-driven analysis. Brady has over 10 years experience working in sports media, with work published by outlets such as ESPN, CBS Sports, Yahoo! Sports and Fox Sports.

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