Diamondbacks vs Cubs Odds and Picks (May 21)

By John Perrotto in MLB Baseball
Published:

- The Cubs are -150 home favorites over the Diamondbacks on Saturday
- Justin Steele (1-4, 4.50) will start for Chicago against fellow lefty Madison Bumgarner (2-2, 2.29)
- A look at the matchup and odds can be found below with a pick
The Arizona Diamondbacks will try to make it three in a row against the host Chicago Cubs when the teams meet at 2:20pm ET Saturday at Wrigley Field.
The Diamondbacks (20-21, 10-10 road) have won the first two games of the four-game series, including 10-6 on Friday, after coming into Chicago on a six-game losing streak. The Cubs (15-23, 6-14 home) have lost three games in a row.
Diamondbacks vs Cubs Odds
Team | Moneyline | Runline | Total |
---|---|---|---|
Arizona Diamondbacks | +125 | OFF | OFF |
Chicago Cubs | -150 | OFF | OFF |
Odds as of May 20th at BetMGM

The Cubs are -150 favorites, giving them a 60% expected win probability. Both teams have long World Series odds as the Cubs are listed at +35000 and the Diamondbacks at +60000.
The weather forecast calls for a chilly and rainy afternoon in Wrigleyville with the temperature 52 degrees at gametime, and northwest winds from 5-15 mph and gusts up to 20 mph. There is an 80% chance of showers and possible thunderstorms.
Probable Pitchers
In a matchup of left-handers, the Diamondbacks’ Madison Bumgarner (2-2, 2.29) will face Justin Steele (1-4, 4.50). Bumgarner will be pitching on four days of rest and Steele on five.
Bumgarner vs Steele
2-2 | Record | 1-4 |
2.29 | ERA | 4.50 |
3.94 | xERA | 3.20 |
1.19 | WHIP | 1.57 |
1.50 | SO/W | 1.93 |
Bumgarner had a no-decision against the Dodgers on Monday in Los Angeles, allowing three runs and six hits in five innings with two walks and a strikeout.
Against the Cubs, Bumgarner has a 9-3 career record and 2.40 ERA in 16 starts. He is 4-2 with a 3.44 ERA in six starts at Wrigley Field.
This, of course, is Bumgarner’s most memorable moment of 2022.
Madison Bumgarner getting ejected right after a hand massage is hilarious pic.twitter.com/jDPbZV8iVL
— Welcome to the Ump Show (@umpjob) May 4, 2022
Bumgarner is 1-2 with a 2.81 ERA in four road starts this season and 0-1 despite a sparkling 0.82 ERA in three days games.
Jonathan Villar is 5-for-7 against Bumgarner with two doubles and a home run. Conversely, Ian Happ is 0_for-5.
Steele is 0-4 in his last six starts since beating the Milwaukee Brewers on April 9 in his season debut.
However, Steele pitched well against the Diamondbacks last Sunday in Phoenix despite not factoring in the decision. He worked six innings and gave up two runs (one earned), three hits and two walks while striking out a career-high 10.
That was Steele’s first career start against the Diamondbacks.
Justin Steele struck out 10 batters in today’s game, setting a new career high 🔥
(📸: @WatchMarquee) @J_Steele21 pic.twitter.com/3sKc1WgtdG
— Cubs Zone (@CubsZone) May 15, 2022
Steele is 1-3 with a 5.52 ERA at home in four starts this season. In the day, he has a 1-1 record and a 2.57 ERFA in three starts.
Diamondbacks vs Cubs Betting Outlook
Josh Rojas hit his first three home runs of the season – in a game that had 11 total longballs – to power the Diamondbacks to victory Friday.
Rojas began the season on the injured list with a strained right oblique before being activated May 6. He had solo homers in the third and seventh innings and a two-run blast in the fifth.
.@Dbacks slugger @JoshRojass intentionally didn't take BP today…
Seemed to work out pretty well for him! #MLBTonight pic.twitter.com/GbzAXIk3ET
— MLB Network (@MLBNetwork) May 20, 2022
David Peralta added two home runs for the Diamondbacks, while Alek Thomas. Christian Walker hit solo shots.
Villar doubled and homered for the Cubs while playing in his 1,000th career game. Rookie Christian Morel hit his first major league home run and Patrick Wisdom and Ildemaro Vargas also connected.
Arizona recalled outfielder Jake McCarthy from Triple-A Reno before the game, and he had two hits and two RBIs. Ketel Marte (hand) sat out for the third time in four games but is expected to play Saturday.
So you decided to run on Seiya Suzuki: pic.twitter.com/9vBKIPWDQj
— Chicago Cubs (@Cubs) May 18, 2022
Shortstop Andrelton Simmons and right fielder Seiya Suzuki, who has +6000 NL MVP odds, are expected to play after being rested Friday.
The Diamondbacks have won three of five games against the Cubs this year, but Chicago has a 26-17 edge in the series since the start of the 2015 season.
Diamondbacks vs Cubs Last 10 Games
Date | Home Team | Away Team | Score |
---|---|---|---|
5/20/22 | Cubs | Diamondbacks | ARI, 10-6 |
5/19/22 | Cubs | Diamondbacks | ARI, 3-1 |
5/15/22 | Diamondbacks | Cubs | CHC, 3-2 |
5/14/22 | Diamondbacks | Cubs | CHC, 4-2 |
5/13/22 | Diamondbacks | Cubs | ARI, 5-4 |
7/25/21 | Cubs | Diamondbacks | CHC, 5-1 |
7/24/21 | Cubs | Diamondbacks | ARI, 7-3 |
7/23/21 | Cubs | Diamondbacks | CHC, 8-3 |
7/18/21 | Diamondbacks | Cubs | ARI, 6-4 |
7/17/21 | Diamondbacks | Cubs | CHC, 4-2 |
Diamondbacks vs Cubs Prediction
The moneyline seems a bit high considering Bumgarner is pitching for the Diamondbacks. However, the Cubs are the way to go after the way Steele dominated Arizona last weekend.
Pick: Cubs ML (-150)
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Sports Writer
John Perrotto has been covering and writing about sports for various outlets for over 40 years. His work has appeared in the likes of USA TODAY, ESPN.com, SI.com, Forbes.com, The Associated Press, Baseball Digest, and more. John is based out of Beaver Falls, PA.