Reds vs Blue Jays Odds and Picks (May 21)

By John Perrotto in MLB Baseball
Published:

- The Blue Jays are -250 home favorites over the Reds on Saturday
- Alek Manoah (4-1, 1.71) will start for Toronto against rookie Hunter Greene (1-6, 6.21)
- A look at the matchup and odds can be found below with a pick
The Toronto Blue Jays look to continue their winning ways when they host the Cincinnati Reds at 3:07pm ET Saturday at Rogers Centre.
The Blue Jays (21-18, 13-7 home) notched a 2-1 victory Friday night in the opener of the three-game series for their third win in four games after losing six of seven. The Reds (11-27, 6-18 road) were coming off a two-game road sweep of the Cleveland Guardians.
Reds vs Blue Jays Odds
Team | Moneyline | Runline | Total |
---|---|---|---|
Cincinnati Reds | +200 | +1.5 (+100) | Over 8 (-110) |
Toronto Blue Jays | -250 | -1.5 (-120) | Under 8 (-110) |
Odds as of May 20th at BetMGM.

As -250 favorites, the Blue Jays have an implied win probability of 71.43% The Blue Jays have +900 World Series odds, but the Reds are listed at +9000.
The roof will likely be closed at Rogers Centre as the weather forecast calls for a rainy Saturday.
Probable Pitchers
Rookie Hunter Greene (1-6, 6.21) is scheduled to pitch for the Reds against Alek Manoah (4-1, 1.71). Both will be working on five days of rest.
Greene vs Manoah Stats
1-6 | Record | 4-1 |
6.21 | ERA | 1.71 |
4.54 | xERA | 2.39 |
1.56 | WHIP | 0.88 |
2.20 | SO/W | 4.33 |
Greene is coming off a heartbreaking loss last Sunday in which he held the Pirates hitless for 7.1 innings but was charged with the game’s only run after walking the first two batters in the eighth inning. He had nine strikeouts and five walks while losing his sixth straight start.
Hunter Greene plays football now too? pic.twitter.com/pDCvdYSP7y
— .🪤. (@ILiveOffHate) May 20, 2022
Greene will be facing the Blue Jays for the first time. So far this season, he is 1-4 with a 6.57 ERA in five starts on the road and has a 1-2 record and 7.20 in three starts in the daylight.
Manoah took his first loss of the season Sunday against the Rays at Tampa Bay, despite turning in a quality start. In six innings, he allowed three runs (one earned), five hits and no walks to go with four strikeouts.
At Rogers Centre this season, Manoah is 2-0 with a 1.42 ERA in three starts. He has made five starts in day games, going 3-1 with a 2.10 ERA.
this city loves alek manoah pic.twitter.com/k2jOCaX4fT
— maddie (@maddiecholette) May 17, 2022
This will be Manoah’s first career appearance against the Reds. He has +1100 AL Cy Young odds.
Reds vs Blue Jays Betting Outlook
The Blue Jays improved to 11-6 in one-run games this season with Friday night’s win and lead the major leagues in that category.
Toronto broke a scoreless tie in the fifth inning. George Springer had an RBI single and scored on Bo Bichette’s double.
You know we like our chicken fried,
Cold beer on a Friday night,
Pair of jeans that fit just right,
And our Blue Jays UUUUUUUP 🤠 pic.twitter.com/ve8Ni16btn— Toronto Blue Jays (@BlueJays) May 21, 2022
The Reds got their run in the seventh on Matt Reynolds’ single. He had three of Cincinnati’s eight hits.
The Reds are 1-6 in one-run games and have the fewest wins in those situations in the majors this season.
Reds first baseman Joey Votto came off the COVID-19 IL and was 1-for-4 with a double for just his second extra-base hit of 2022. He played in his first game in his native Canada since 2017.
"Joey Votto, back home." 👏👏 pic.twitter.com/IUaUn0gMJJ
— Bally Sports Cincinnati (@BallySportsCIN) May 20, 2022
Cincinnati reliever Joel Kuhnel, infielder Brandon Drury and outfielder Albert Almora Jr. were placed on the restricted list. They were unable to cross the Canadian border because they are not vaccinated against COVID-19.
Blue Jays left fielder Lourdes Gurriel Jr. sat out the game with a tight left hamstring and is questionable for Saturday.
The Blue Jays swept a three-game series in the teams’ last meeting in 2017 before Friday.
Reds vs Blue Jays Last 10 Games
Date | Home Team | Away Team | Score |
---|---|---|---|
5/20/22 | Blue Jays | Reds | TOR, 2-1 |
5/31/17 | Blue Jays | Reds | TOR, 5-4 |
5/30/17 | Blue Jays | Reds | TOR, 6-4 |
5/29/17 | Blue Jays | Reds | TOR, 17-2 |
6/22/14 | Reds | Blue Jays | CIN, 4-3 |
6/21/14 | Reds | Blue Jays | CIN, 11-1 |
6/20/14 | Reds | Blue Jays | TOR, 14-9 |
6/19/11 | Reds | Blue Jays | CIN, 2-1 |
6/18/11 | Reds | Blue Jays | TOR, 4-0 |
6/17/11 | Reds | Blue Jays | TOR, 3-2 |
Reds vs Blue Jays Prediction
Even though Greene didn’t allow a hit in his last start, it’s tough to buck Manoah, especially at home. The Blue Jays are the play here even laying a huge number.
Pick: Blue Jays ML -250
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Sports Writer
John Perrotto has been covering and writing about sports for various outlets for over 40 years. His work has appeared in the likes of USA TODAY, ESPN.com, SI.com, Forbes.com, The Associated Press, Baseball Digest, and more. John is based out of Beaver Falls, PA.