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Opening College Football Week 3 Odds, Spreads and Early Predictions

John Perrotto

by John Perrotto in College Football

Updated Sep 15, 2023 · 9:10 PM PDT

Kansas State senior quarterback Will Howard scoring a TD
Kansas State senior quarterback Will Howard (18) runs in for a touchdown against Southeast Missouri during the second quarter of Saturday's game inside Bill Snyder Family Stadium.
  • Week 3 of the college football season starts in earnest Friday night with Virginia vs Maryland
  • #1 Georgia has opened as a 27.5-point home favorite over South Carolina
  • A look at all the college football Week 3 opening odds can be found below with early picks

The first game of Week 3 of the college football season involving Power Five schools will be played Friday night when Maryland hosts former ACC rival Virginia. The Terrapins open as 17.5-point favorites.

Maryland ran its record to 2-0 after beating Charlotte 38-20 on Saturday night. Virginia lost a 36-35 heartbreaker to visiting James Madison on Saturday to drop to 0-2.

There are no games involving two ranked teams this week. Top-ranked Georgia is a 27.5-point favorite over South Carolina.

College Football Week 3 Opening Odds

Game Time (Eastern) Team Spread Moneyline
7 p.m. Virginia +17.5 (-110) OFF
Friday, Sept. 15 Maryland -17.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
12 p.m. Louisville -11 (-110) OFF
Saturday, Sept. 16 Indiana +11 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
12 p.m. Iowa State -1.5 (-110) OFF
Saturday, Sept. 16 Ohio +1.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
12 p.m. Wake Forest -13.5 (-110) OFF
Saturday, Sept. 16 Old Dominion +13.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
12 p.m. Georgia Southern +16.5 (-110) OFF
Saturday, Sept. 16 Wisconsin -16.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
12 p.m. Florida State -28 (-110) OFF
Saturday, Sept. 16 Boston College +28 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
12 p.m. Penn State -15 (-110) OFF
Saturday, Sept. 16 Illinois +15 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
12 p.m. LSU -8.5 (-110) OFF
Saturday, Sept. 16 Mississippi State +8.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
12 p.m. Kansas State -3 (-110) OFF
Saturday, Sept. 16 Missouri +3 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
2:30 p.m. Central Michigan +31.5 (-110) OFF
Saturday, Sept. 16 Notre Dame -31.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
3:30 p.m. Northwestern +19.5 (-110) OFF
Saturday, Sept. 16 Duke -19.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
3:30 p.m. South Carolina +27.5 (-110) OFF
Saturday, Sept. 16 Georgia -27.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
3:30 p.m. Western Michigan +24.5 (-110) OFF
Saturday, Sept. 16 Iowa -24.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
3:30 p.m. Minnesota +6 (-110) OFF
Saturday, Sept. 16 North Carolina -6 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
3:30 p.m. San Diego State +23.5 (-110) OFF
Saturday, Sept. 16 Oregon State -23.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
3:30 p.m. Virginia Tech +4 (-110) OFF
Saturday, Sept. 16 Rutgers -4 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
3:30 p.m. Alabama -35 (-110) OFF
Saturday, Sept. 16 South Florida +35 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
3:30 p.m. Oklahoma -26.5 (-110) OFF
Saturday, Sept. 16 Tulsa +26.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
4 p.m. Western Kentucky +28.5 (-110) OFF
Saturday, Sept. 16 Ohio State -28.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
4 p.m. UL-Monroe +33 (-110) OFF
Saturday, Sept. 16 Texas A&M -33 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
4 p.m. Tulane -11 (-110) OFF
Saturday, Sept. 16 Southern Miss +11 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
5 p.m. Washington -14 (-110) OFF
Saturday, Sept. 16 Michigan State +14 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
7 p.m. Miami (Ohio) +16.5 (-110) OFF
Saturday, Sept. 16 Cincinnati -16.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
7 p.m. Akron +24.5 (-110) OFF
Saturday, Sept. 16 Kentucky -24.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
7 p.m. Northern Illinois +13.5 (-110) OFF
Saturday, Sept. 16 Nebraska -13.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
7 p.m. South Alabama +9 (-110) OFF
Saturday, Sept. 16 Oklahoma State -9 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
7 p.m. Vanderbilt -3.5 (-110) OFF
Saturday, Sept. 16 UNLV +3.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
7 p.m. Tennessee -7 (-110) OFF
Saturday, Sept. 16 Florida +7 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
7:30 p.m. BYU +11.5 (-110) OFF
Saturday, Sept. 16 Arkansas -11.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
7:30 p.m. Bowling Green +39.5 (-110) OFF
Saturday, Sept. 16 Michigan -39.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
7:30 p.m. Georgia Tech +20.5 (-110) OFF
Saturday, Sept. 16 Ole Miss -20.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
7:30 p.m. Syracuse +2.5 (-110) OFF
Saturday, Sept. 16 Purdue -2.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
7:30 p.m. Pittsburgh +1 (-110) OFF
Saturday, Sept. 16 West Virginia -1 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
8 p.m. Florida Atlantic +25.5 (-110) OFF
Saturday, Sept. 16 Clemson -25.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
8 p.m. TCU -6.5 (-110) OFF
Saturday, Sept. 16 Houston +6.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
8 p.m. Hawaii +36 (-110) OFF
Saturday, Sept. 16 Oregon -36 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
8 p.m. Wyoming +29.5 (-110) OFF
Saturday, Sept. 11 Texas -29.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
10 p.m. Colorado State +21.5 (-110) OFF
Saturday, Sept. 16 Colorado -21.5 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
10:30 p.m. Fresno State Pk (-110) OFF
Saturday, Sept. 16 Arizona State Pk (-110) OFF
Game Time (Eastern) Team Spread Moneyline
10:30 p.m. Kansas -27 (-110) OFF
Saturday, Sept. 16 Nevada +27 (-110) OFF
Game Time (Eastern) Team Spread Moneyline
11 p.m. UTEP +16.5 (-110) OFF
Saturday, Sept. 16 Arizona -16.5 (-110) OFF

#2 Michigan is the week’s biggest opening favorite at 39.5 points over Bowling Green at home. The lowest spread is pick for Fresno State vs Arizona State.

 

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Looking for the latest odds? Check out the updated Week 3 college football odds in our line movement article.

Kansas State vs Missouri Early Odds & Prediction

One-time Big 12 rivals square off when #15 Kansas State visits Missouri on Saturday at Faurot Field in Columbia as a three-point favorite over Mizzou. Both teams are off to 2-0 starts.

Will Howard threw for three touchdowns and ran for two more as Kansas State dispatched Troy 42-13 at home on Saturday. Howard finished 21-of-32 passing for 250 yards and added 33 yards rushing on eight carries.

Missouri got past visiting Middle Tennessee State 23-19 as Brady Cook completed 14 of 19 passes for 204 yards and two TDs. He also ran for a score.

This line seems awfully light at three points. It would be wise to jump on Kansas State before it goes higher.

Pick: Kansas State -3 (-110)

Georgia vs South Carolina Early Odds & Prediction

#1 Georgia (2-0) opens SEC play by hosting South Carolina (1-1) at Sanford Stadium in Athens.

Walk-on Mekhi Mews’ 69-yard punt return for a touchdown sparked Georgia’s 45-3 rout of visiting Ball State on Saturday. The Bulldogs also intercepted three passes.

Spencer Rattler connected on 25 of 27 passing attempts for 345 yards and three touchdowns to help South Carolina dispatch in-state rival Furman 47-21 at home. He is averaging 348 yards passing over his last five games dating to last season after having a 198-yard average in his first 10 starts for the Gamecocks.

Georgia’s defense is awfully good. However, Rattler is hot and should enable South Carolina to sneak under the number.

Pick: South Carolina +27.5 (-110)

That’s Outta Line

Purdue has opened as a 2.5-point home favorite over Syracuse but that spread seems off. Though the Boilermakers (1-1) beat Virginia Tech 24-17 on the road Saturday, a strong case can be made that the Orange (2-0), who have outscored their first two opponents 113-7, are the better team and should be favored.

Pick: Syracuse +2.5 (-110)

Season record: 2-3 (-1.3 units) ATS

 

 

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