Opening College Football Week 3 Odds, Spreads and Early Predictions

• Week 3 of the college football season starts in earnest Friday night with Virginia vs Maryland
• #1 Georgia has opened as a 27.5-point home favorite over South Carolina
• A look at all the college football Week 3 opening odds can be found below with early picks

The first game of Week 3 of the college football season involving Power Five schools will be played Friday night when Maryland hosts former ACC rival Virginia. The Terrapins open as 17.5-point favorites.

Maryland ran its record to 2-0 after beating Charlotte 38-20 on Saturday night. Virginia lost a 36-35 heartbreaker to visiting James Madison on Saturday to drop to 0-2.

There are no games involving two ranked teams this week. Top-ranked Georgia is a 27.5-point favorite over South Carolina.

College Football Week 3 Opening Odds

#2 Michigan is the week’s biggest opening favorite at 39.5 points over Bowling Green at home. The lowest spread is pick for Fresno State vs Arizona State.

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Odds as of September 10th at DraftKings. Claim a DraftKings promo to bet on NCAAF Week 3 games. 

Looking for the latest odds? Check out the updated Week 3 college football odds in our line movement article.

Kansas State vs Missouri Early Odds & Prediction

One-time Big 12 rivals square off when #15 Kansas State visits Missouri on Saturday at Faurot Field in Columbia as a three-point favorite over Mizzou. Both teams are off to 2-0 starts.

Will Howard threw for three touchdowns and ran for two more as Kansas State dispatched Troy 42-13 at home on Saturday. Howard finished 21-of-32 passing for 250 yards and added 33 yards rushing on eight carries.

That's S I X for @KStateFB's QB @whoward_ 👏🤩 pic.twitter.com/iItBEpeCKr

— FOX College Football (@CFBONFOX) September 9, 2023

Missouri got past visiting Middle Tennessee State 23-19 as Brady Cook completed 14 of 19 passes for 204 yards and two TDs. He also ran for a score.

This line seems awfully light at three points. It would be wise to jump on Kansas State before it goes higher.

Pick: Kansas State -3 (-110)

Georgia vs South Carolina Early Odds & Prediction

#1 Georgia (2-0) opens SEC play by hosting South Carolina (1-1) at Sanford Stadium in Athens.

Walk-on Mekhi Mews’ 69-yard punt return for a touchdown sparked Georgia’s 45-3 rout of visiting Ball State on Saturday. The Bulldogs also intercepted three passes.

MEWWWS.

Watch live on SEC Network#GoDawgs | @mekhi_mews_21 pic.twitter.com/3GMxzl5NWB

— Georgia Football (@GeorgiaFootball) September 9, 2023

Spencer Rattler connected on 25 of 27 passing attempts for 345 yards and three touchdowns to help South Carolina dispatch in-state rival Furman 47-21 at home. He is averaging 348 yards passing over his last five games dating to last season after having a 198-yard average in his first 10 starts for the Gamecocks.

Georgia’s defense is awfully good. However, Rattler is hot and should enable South Carolina to sneak under the number.

Pick: South Carolina +27.5 (-110)

That’s Outta Line

Purdue has opened as a 2.5-point home favorite over Syracuse but that spread seems off. Though the Boilermakers (1-1) beat Virginia Tech 24-17 on the road Saturday, a strong case can be made that the Orange (2-0), who have outscored their first two opponents 113-7, are the better team and should be favored.

Pick: Syracuse +2.5 (-110)

Season record: 2-3 (-1.3 units) ATS