NFL Week 15 Odds – Opening Betting Lines & Spreads for All Games

• NFL Week 15 begins with the 49ers as three-point road favorites over the Seahawks on Thursday Night Football
• The Chiefs are the week’s biggest favorites at 14 points over the Texans
• All the NFL Week 15 openings odds can be found below with early picks

Week 15 of the NFL season beings with the San Francisco 49ers visiting the Seattle Seahawks on Thursday Night Football.

The 49ers (9-4) ran their winning streak to six games Sunday by thumping the Tampa Bay Buccaneers 35-7. The Seahawks (7-6) lost to the Carolina Panthers 30-24 for their third defeat in four games.

San Francisco now holds a two-game lead over Seattle in the NFC West.

Three games are on tap for Saturday: Indianapolis Colts at Minnesota Vikings, Baltimore Ravens at Cleveland Browns, and Miami Dolphins at Buffalo Bills. The Vikings are favored by 4.5 points, the Browns are three-point choices, and the Bills are 6.5-point picks.

Sunday Night Football features the Washington Commanders hosting the New York Giants. The Los Angeles Rams visit the Green Bay Packers on Monday Night Football. The Commanders are favored by 3.5 points and the Packers by 7.5 points.

All the NFL odds will be updated throughout the week

NFL Week 15 Opening Odds

Odds as of December 11th at FanDuel Sportsbook.

The Kansas City Chiefs are NFL Week 15’s biggest opening favorites by 14 points over the Houston Texans. The smallest favorites are the Arizona Cardinals by one point against the Denver Broncos.

The highest over/under is 48 points for the Detroit Lions-New York Jets game. Cardinals-Broncos has the lowest total at 38.5.

Dolphins vs Bills Early Odds & Prediction

The 6.5-point spread for Miami vs Buffalo seems a touch light for this AFC East matchup. The Bills (10-3) have won four games in a row and are again looking like Super Bowl contenders with as much talent as any team in the league.

The Bills beat the New York Jets 20-12 on Sunday. Josh Allen threw a touchdown pass and ran for a score on consecutive possessions spanning the second and third quarters.

.@JoshAllenQB for 6️⃣‼️

📺: @NFLonCBS | #ProBowlVote pic.twitter.com/mtfrqPFkd9

— Buffalo Bills (@BuffaloBills) December 11, 2022

Allen’s TD pass was a 24-yarder to Dawson Knox. Allen was 16-of-27 passing for a season-low 147 yards.

The Dolphins (8-4) visited the San Diego Chargers on Sunday night.

The Bills can basically wrap up the AFC East with a win, so look for a spirited effort in front of Bills Mafia in Orchard Park

Pick: Bills -6.5 (-115)

Bengals vs Buccaneers Early Odds & Prediction

The Bengals (9-4), who are on a five-game winning streak, have opened as three-point road favorites over the Buccaneers (6-7) late Sunday afternoon.

Joe Burrow threw two touchdown passes to lead the Bengals over the Cleveland Browns 23-10 on Sunday. His scoring throws covered 15 yards to Ja’Marr Chase and 45 yards to Trenton Irwin.

Chase had 10 receptions for 119 yards. Burrow finished with 239 passing yards.

The griddy is back 😏#ProBowlVote x #JaMarrChase#CLEvsCIN | 📺 CBS pic.twitter.com/ntoIxj78pu

— Cincinnati Bengals (@Bengals) December 11, 2022

The Buccaneers had won three of their last four games before getting smacked by the 49ers but still lead the NFC South. Tom Brady was intercepted twice while completing 34 of 55 passes for 253 yards and one touchdown.

It remains hard to believe a team quarterbacked by Brady has a losing record 13 games into a season. Look for the Buccaneers to bounce back.

Pick: Buccaneers +3 (-106)

Ravens vs Browns Early Odds & Prediction

The 5-8 Browns are favored primarily because the Ravens could be down to their third-string quarterback.

The Ravens beat the Pittsburgh Steelers 16-14 on Sunday in a game in which the Ravens lost backup quarterback Tyler Huntley.  He filled in for injured Lamar Jackson but entered the concussion protocol in the second half.

Undrafted rookie Anthony Brown finished the game.

Browns quarterback Deshaun Watson threw his first touchdown in 707 days, 13 yards to David Njoku, in the loss to the Bengals but it wasn’t enough.

Even if the Ravens must rely on Brown, they look good getting the points.

Pick: Ravens +3 (+115)