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NFL Week 2 Odds – Opening Betting Lines & Spreads for All Games

John Perrotto

by John Perrotto in NFL Football

Updated Sep 10, 2023 · 6:01 PM PDT

Buffalo Bills quarterback Josh Allen (17) makes adjustments at the line
Aug 26, 2023; Chicago, Illinois, USA; Buffalo Bills quarterback Josh Allen (17) makes adjustments at the line against the Chicago Bears during the first quarter at Soldier Field. Mandatory Credit: Daniel Bartel-USA TODAY Sports
  • The Eagles host the Vikings as 7.5-point favorites in the opening NFL Week 2 odds on Thursday Night Football
  • The Bills are Week 2’s biggest favorites by 9.5 points over the Raiders
  • A look at all the NFL Week 2 opening odds can be found below with early predictions

Week 2 of the NFL season begins when the Minnesota Vikings visit the Philadelphia Eagles on Thursday Night Football. See the odds for TNF plus all of the opening NFL Week 2 odds here.

The Eagles have opened as 7.5-point favorites in the NFL odds after holding off the New England Patriots 25-20 on Sunday to open the season. The Vikings were upset by the Tampa Bay Buccaneers 20-17 in their opener.

Sunday Night Football will feature the Patriots hosting the Miami Dolphins, who are two-point favorites.

There will be two games on Monday Night Football with the New Orleans Saints and Carolina Panthers playing in Charlotte on ESPN and the Cleveland Browns facing the Steelers in Pittsburgh on ABC. The Saints are 2.5-point picks and the Browns are favored by 1.5 points in the early NFL Week 2 odds.

NFL Week 2 Opening Odds

Team Moneyline Spread Over/Under
Minnesota Vikings +310 +7.5 (-105) Over 48.5 (-110)
Philadelphia Eagles -390 -7.5 (-115) Under 48.5 (-110)
Team Moneyline Spread Over/Under
Los Angeles Chargers -146 -2.5 (-120) Over 46.5 (-110)
Tennessee Titans +124 +2.5 (-102) Under 46.5 (-110)
Team Moneyline Spread Over/Under
Green Bay Packers -108 -1 (-104) Over 41.5 (-110)
Atlanta Falcons -108 +1 (-118) Under 41.5 (-110)
Team Moneyline Spread Over/Under
Indianapolis Colts -112 -1.5 (-105) Over 40.5 (-110)
Houston Texans -104 +1.5 (-115) Under 40.5 (-110)
Team Moneyline Spread Over/Under
Seattle Seahawks +184 +4.5 (-105) Over 50.5 (-110)
Detroit Lions -220 -4.5 (-115) Under 50.5 (-110)
Team Moneyline Spread Over/Under
Chicago Bears +116 +2.5 (-110) Over 43.5 (-110
Tampa Bay Buccaneers -136 -2.5 (-110) Under 43.5 (-110)
Team Moneyline Spread Over/Under
Las Vegas Raiders +370 +9.5 (-110) Over 48 (-110)
Buffalo Bills -480 -9.5 (-110) Under 48 (-110)
Team Moneyline Spread Over/Under
Kansas City Chiefs -144 -3 (-105) Over 51.5 (-110)
Jacksonville Jaguars +122 +3 (-115) Under 51.5 (-110)
Team Moneyline Spread Over/Under
Baltimore Ravens +130 +3 (-115) Over 46 (-110)
Cincinnati Bengals -154 -3 (-105) Under 46 (-110)
Team Moneyline Spread Over/Under
New York Giants -210 -5 (-110) Over 39.5 (-110)
Arizona Cardinals +176 +5 (-110) Under 39.5 (-110)
Team Moneyline Spread Over/Under
San Francisco 49ers -295 -7 (-105) Over 43.5 (-110)
Los Angeles Rams +240 +7 (-115) Under 43.5 (-110)
Team Moneyline Spread Over/Under
New York Jets +132 +3 (-110) Over 45 (-110)
Dallas Cowboys -156 -3 (-110) Under 45 (-110)
Team Moneyline Spread Over/Under
Washington Commanders +160 +3.5 (-105) Over 40 (-110)
Denver Broncos -190 -3.5 (-115) Under 40 (-110)
Team Moneyline Spread Over/Under
Miami Dolphins -134 -2 (-115) Over 45.5 (-110)
New England Patriots +114 +2 (-105) Under 45.5 (-110)
Team Moneyline Spread Over/Under
New Orleans Saints -142 -2.5 (-115) Over 40.5 (-110)
Carolina Panthers +120 +2.5 (-105) Under 40.5 (-110)
Team Moneyline Spread Over/Under
Cleveland Browns -124 -1.5 (-110) Over 42.5 (-110)
Pittsburgh Steelers +106 +1.5 (-110) Under 42.5 (-110)

The Buffalo Bills are Week 2’s biggest opening favorites at 9.5 points over the visiting Las Vegas Raiders. The slimmest line is the one point the Green Bay Packers are favored by over the Falcons in Atlanta. The highest over/under is 51.5 points for Kansas City Chiefs vs Jacksonville Jaguars and the lowest is 39.5 for New York Giants vs Arizona Cardinals.

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Ravens vs Bengals Odds & Prediction

The Bengals are three-point favorites as the AFC North rivals meet at 1 p.m. ET Sunday at Paul Brown Stadium in Cincinnati after the two teams opened their season in opposite fashions.

The Ravens beat the visiting Houston Texas 25-9 on Sunday, but the victory was dampened by bad news. Justice Hill had two rushing touchdowns for Baltimore after fellow running back JK Dobbins sustained a season-ending torn Achilles tendon.

The Bengals were handled by the Browns 24-3 in Cleveland. Two days after signing an NFL-record contract extension worth $275 over five years, Cincinnati quarterback Joe Burrow passed for just 82 yards as he completed 14 of 31 attempts.

Look for Burrow and the Bengals to bounce back, though, in their home opener.

Pick: Bengals -3 (-105)

Jets vs Cowboys Early Odds & Prediction

The Jets host the Bills on Monday night in their season opener. With his Jets’ debut having been behind him, quarterback Aaron Rodgers will face a team he is quite familiar with when New York visits the Dallas Cowboys at 4:25 p.m. ET Sunday at AT&T Stadium in Arlington, Texas as a three-point underdog in the NFL Week 2 odds.

The Cowboys opened their season Sunday night on the road against the New York Giants. The Jets begin their season Monday night against the Bills at home after acquiring Rodgers, a four-time NFL MVP, from the Packers in an offseason trade.

The Jets’ first road game of the season will test them. However, Rodgers has seen it all in his 18-year career and the underdog is 4-1-1 ATS in the last six games of this series.

Pick: Jets +3 (-110)

Movement on the Line in Bucs vs Bears?

The Buccaneers have opened as 2.5-point road favorites over the Bears on Sunday in Tampa in the NFL Week 2 odds. The line is in reaction to the Week 1 results in which Tampa Bay upset the Vikings and the Bears were thumped by the Packers 38-20.

It says here that the Bears are still the better team, and the line should at least move slightly in their direction.

Pick: Bears +2.5 (-110)

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