Upcoming Match-ups
Today
8
May
8:00 PM
IND
NY
+4.5
-4.5
222
Tmrw
9
May
7:00 PM
CLE
BOS
+13.5
-13.5
212.5
9:30 PM
DAL
OKC
+3
-3
214.5
Friday
10
May
9:30 PM
DEN
MIN
+4.5
-4.5
205
  1. Home
  3. NFL Football
  5. NFL Odds
  7. Arizona Cardinals VS San Francisco 49ers

Arizona Cardinals VS San Francisco 49ers

Football Icon
Odds & Matchup Stats
Arizona Logo

Arizona

7-1

vs
San Francisco Logo

San Francisco

3-4

November 7, 2021

4:25 PM EST

Levi's Stadium

Closing Odds

Matchupfanduel Logodraftkings Logobetmgm LogoBet %Money %Consensus
Arizona Team LogoArizona
+2.5 -105
+2.5 -110
+2.5 -110
84%
San Francisco Team LogoSan Francisco
-2.5 -115
-2.5 -110
-2.5 -110
16%

This game was played on November 7, 2021. Closing Odds were accurate as of 4:25 pm. Check out upcoming NFL Odds.

SHARE A LINK

SHARE THIS PAGE

Predicted Score

Arizona Logo

23.5 - 18.3

San Francisco Logo

Our formula predicts the Arizona Cardinals will beat the San Francisco 49ers by a score of 23.5–18.3.

Win Probability

Arizona Logo

42.3% - 57.7%

San Francisco Logo

The 49ers have a 57.7% chance of beating the Cardinals based off the odds.

Pick

Arizona Logo

Arizona To Win

Cardinals COVER the +2.5 spread and the total is UNDER 45.5

SportsBettingDime’s formula is picking the Cardinals (+2.5) to cover the spread, and has the total going Under 45.5.

Consensus
Picks

Arizona Team Logo
San Francisco Team Logo
50%
50%
50%
50%
50%
50%
MLATSO/U

Trends

Arizona Team Logo

Arizona

San Francisco Team Logo

San Francisco

The Cardinals lost their last game.

RETURN ON INVESTMENT: LAST 10 GAMES

Date
ML
ATS
OVER
UNDER

KEY INSIGHT: Available exclusively for SBD Plus users. Login or Register for FREE.

Arizona Team Logo

Arizona

The Cardinals lost their last game.

RETURN ON INVESTMENT: LAST 10 GAMES

Date
ML
ATS
OVER
UNDER

KEY INSIGHT: Available exclusively for SBD Plus users. Login or Register for FREE.

San Francisco Team Logo

San Francisco

The 49ers won their last game.

RETURN ON INVESTMENT: LAST 10 GAMES

Date
ML
ATS
OVER
UNDER

KEY INSIGHT: Available exclusively for SBD Plus users. Login or Register for FREE.

Understanding Return on Investment Trends

SBD Sharp measures the profitability of teams over time. A positive percentage indicates that betting the team has been profitable in recent games. Visit SBD Sharp for a detailed explanation of ROI trends or register for your free SBD Plus account account today.

Futures Trackers

Track the Super Bowl odds all season and see how Arizona and San Francisco compare to the top contenders.

Learn More

Stats

Records

Arizona Logo

Arizona

San Francisco

San Francisco Logo
7-1

Overall

3-4
4-0

Away/Home

0-3
6-1Udog/Fav8-5

Each team's record on the moneyline, spread, and over/under, with home and road splits for each.

Team Leaders

Arizona Logo

Kyler Murray

Jimmy Garoppolo

San Francisco Logo
284.5

Passing YPG

238
17

Passing TDs

6
7

INTs

4

Compare key stats for each team's most impactful players.

Head to Head

Arizona Logo

Arizona

San Francisco

San Francisco Logo
Points Per Game (PPG)
30.8
24
Yards Per Game (YPG)
393.6
369.7
Passing Yards Per Game
264.9
246
Rushing Yards Per Game
128.8
123.7
Turnovers Committed
9
11
Points Per Game Allowed
17.3
24.4
Yards Per Game Allowed
319
324
Passing Yards Per Game Allowed
198.9
196.9
Rushing Yards Per Game Allowed
120.1
127.1
Turnovers Forced
14
5

Directly compare team stats for the most important metrics.

Injuries

Arizona Team Logo

Arizona

San Francisco Team Logo

San Francisco

PlayerStatus

DeAndre Hopkins

out

Hamstring

11/07/2021 @ 8:13PM EST

Kyler Murray

out

Ankle

11/07/2021 @ 8:11PM EST

Jonathan Ward

out

Concussion

11/07/2021 @ 2:04AM EST

Rashard Lawrence

I-R

Calf

11/06/2021 @ 11:53PM EDT

J.J. Watt

I-R

Shoulder

11/06/2021 @ 9:41PM EDT

Rodney Hudson

questionable

Ribs

11/06/2021 @ 9:39PM EDT

James Wiggins

out

Knee

11/06/2021 @ 3:52PM EDT

Justin Pugh

probable

Calf

11/05/2021 @ 10:14PM EDT

Chase Edmonds

probable

Shoulder

11/05/2021 @ 10:13PM EDT

Zaven Collins

probable

Shoulder

11/05/2021 @ 10:11PM EDT

Arizona Team Logo

Arizona

PlayerStatus

DeAndre Hopkins

out

Hamstring

11/07/2021 @ 8:13PM EST

Kyler Murray

out

Ankle

11/07/2021 @ 8:11PM EST

Jonathan Ward

out

Concussion

11/07/2021 @ 2:04AM EST

Rashard Lawrence

I-R

Calf

11/06/2021 @ 11:53PM EDT

J.J. Watt

I-R

Shoulder

11/06/2021 @ 9:41PM EDT

Rodney Hudson

questionable

Ribs

11/06/2021 @ 9:39PM EDT

James Wiggins

out

Knee

11/06/2021 @ 3:52PM EDT

Justin Pugh

probable

Calf

11/05/2021 @ 10:14PM EDT

Chase Edmonds

probable

Shoulder

11/05/2021 @ 10:13PM EDT

Zaven Collins

probable

Shoulder

11/05/2021 @ 10:11PM EDT

San Francisco Team Logo

San Francisco

PlayerStatus

George Kittle

probable

Calf

11/07/2021 @ 8:42PM EST

Deommodore Lenoir

out

Personal

11/07/2021 @ 8:41PM EST

Deebo Samuel

probable

Calf

11/07/2021 @ 7:35AM EST

Elijah Mitchell

probable

Ribs

11/07/2021 @ 7:35AM EST

Dee Ford

I-R

Concussion

11/06/2021 @ 9:42PM EDT

Robbie Gould

questionable

Groin

11/06/2021 @ 9:37PM EDT

Jeff Wilson Jr.

questionable

Knee

11/06/2021 @ 9:36PM EDT

Jimmie Ward

out

Quadricep

11/05/2021 @ 10:16PM EDT

Maurice Hurst

out

Calf

11/05/2021 @ 10:15PM EDT

Azeez Al-Shaair

probable

Concussion

11/04/2021 @ 1:37AM EDT

All NFL Odds