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Blue Jays vs Yankees Odds, Runline, & Predictions (April 22)

John Perrotto

by John Perrotto in MLB Baseball

Updated Apr 21, 2023 · 8:42 PM PDT

Vladimir Guerrero Jr. celebrates his two run home run with third base coach Luis Rivera
Apr 21, 2023; Bronx, New York, USA; Toronto Blue Jays first baseman Vladimir Guerrero Jr. (27) celebrates his two run home run with third base coach Luis Rivera (20) during the first inning against the New York Yankees at Yankee Stadium. Mandatory Credit: Vincent Carchietta-USA TODAY Sports
  • The Yankees are -145 home favorites over the Blue Jays on Saturday
  • Alek Manoah (1-1, 6.98) will pitch for the Blue Jays against the Yankees’ Gerrit Cole (4-0, 0.95)
  • A look at the Blue Jays vs Yankees odds and matchup can be found below with a prediction

The visiting Toronto Blue Jays will try to make it two in a row over the New York Yankees when they meet in the middle game of a three-game series at 1:05pm ET Saturday at Yankee Stadium.

The Blue Jays (12-8, 7-6 road) won the series opener 6-1 on Friday night after losing three of their previous four games. The Yankees (12-8, 8-6 home) had won four of their past five games.

The game will be streamed on ESPN+.

Blue Jays vs Yankees Odds

Team Moneyline Runline Total
Toronto Blue Jays +125 +1.5 (-165) Over 7.5 (-110)
New York Yankees -145 -1.5 (+140) Under 7.5 (-110)

Odds as of April 21st at DraftKings.


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Blue Jays vs Yankees Probable Pitchers

Alek Manoah (1-1, 6.98) will start for the Blue Jays against Gerrit Cole (4-0, 0.95). Both will be pitching on five days of rest.

The Yankees are -145 favorites on the moneyline over the Blue Jays in the MLB odds, giving them an implied win probability of 59.18%. New York has +750 World Series championship odds and Toronto is listed at +1200.

It is expected to be a mostly cloudy day in the Bronx with a high of 65 and southeast wind at 8-17 mph.

Manoah has struggled this season, but the Blue Jays are 3-1 when he starts.

Manoah vs Cole Stats

Alek Manoah
Gerrit Cole
1-1 Record 4-0
6.98 ERA 0.95
8.01 xERA 2.80
1.97 WHIP 0.74
1.07 SO/W 4.00

However, the big right-hander took his first loss of the season in his most recent start last Sunday against the Tampa Bay Rays in Toronto. He was rocked for seven runs and nine hits in 4.2 innings with five strikeouts and four walks.

In six career starts against the Yankees, who always have one of the toughest MLB lineups, Manoah has a 2-1 record and 2.31 ERA.

Manoah is 1-0 with a 4.35 ERA in two road starts this season. In two starts during the day, he is 0-1 with a 13.50 ERA.

Cole has won each of his four starts in 2023 and was at his best last Sunday when he shut out the Minnesota Twins on two hits at Yankee Stadium. Cole struck out 10, walked only one and lowered his AL Cy Young odds to +400.

There could be a little tension in this matchup, though.

This will be Cole’s 13th career start against the Blue Jays. He is 6-2 against them and has a 3.76 ERA.

All three of Cole’s starts at Yankee Stadium this season have been during the day, and he has a 3-0 mark with a microscopic 0.42 ERA.

Batting Average vs Starting Pitchers

Blue Jays Batters Batting Average vs Gerrit Cole
Santiago Espinal .375
Alejandro Kirk .364
Whit Merrifield .353
Vladimir Guerrero Jr. .346
George Springer .333
Danny Jansen .333
Brandon Belt .222
Bo Bichette .200
Cavan Biggio .200
Matt Chapman .148
Kevin Kiermaier .147
Yankees Batters Batting Average vs Alek Manoah
Isiah Kiner-Falefa .400
Franchy Cordero .375
Anthony Rizzo .333
Aaron Hicks .222
DJ LeMahieu .182
Gleyber Torres .154
Aaron Judge .063
Jose Trevino .000
Kyle Higashioka .000
Oswaldo Cabrera .000

Blue Jays first baseman Vladimir Guerrero Jr. is 9-for-26 (.346) against Cole with two doubles and two home runs in his career while center fielder Kevin Kiermaier is just a .147 hitter (5-for-34) with one double, one homer and 17 strikeouts.

Yankees center fielder Aaron Judge, whose AL MVP odds are +1000, has only one hit – a home run – in 16 career at-bats against Manoah for a .063 batting average along with six strikeouts. First baseman Anthony Rizzo is 4-for-12 (.333) with three walks.

Blue Jays vs Yankees Betting Outlook

Guerrero hit a two-run home run to open the scoring Friday night and Brandon Belt drove in the Blue Jays’ other four runs in the series opener.

Belt hit a two-run home run and a two-run double as he and Guerrero had two hits each. Belt ended a streak of 38 games without a homer that dates to last season when he was still with the San Francisco Giants.

Oswaldo Cabrera accounted for the Yankees’ lone run with a homer.

Blue Jays vs Yankees Last 10 Games

Date Home Team Away Team Score
4/21/23 Yankees Blue Jays TOR, 6-1
9/28/22 Blue Jays Yankees NYY, 8-3
9/27/22 Blue Jays Yankees NYY, 5-2
9/26/22 Blue Jays Yankees TOR, 3-2
8/21/22 Yankees Blue Jays NYY, 4-2
8/20/22 Yankees Blue Jays TOR, 5-2
8/19/22 Yankees Blue Jays TOR, 4-0
8/18/22 Yankees Blue Jays TOR, 9-2
6/19/22 Blue Jays Yankees TOR, 10-9
6/18/22 Blue Jays Yankees NYY, 4-0

Friday night marked the first game of the season between the American League East rivals after they split 48 games over the previous three seasons.

Blue Jays vs Yankees Prediction

While Manoah is too talented to keep struggling so much, it’s impossible to buck Cole right now.

Pick: Yankees ML (-145)

Season Record: 10-4 (+4.1 units) ML; 1-1 (0 units) RL; 11-4 (+4.1 units) overall

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