Opening College Football Week 5 Odds, Spreads and Early Predictions

• The Week 5 college football odds are out for the majority of games
• NC State vs Clemson is a key ACC matchup
• A look at all college football Week 5 odds and early picks can be found below

Week 5 of the college football season begins Thursday night with Utah State vs #19 BYU.

There will be four games involving ranked teams Saturday, including #10 North Carolina State vs #5 Clemson and #21 Wake Forest vs #23 Florida State in the ACC along with #7 Kentucky vs #14 Mississippi and #2 Alabama vs #20 Arkansas in the SEC.

The table below shows the NCAAF Week 5 opening lines. Check the college football odds page during the week for updated point spreads, moneylines, and game totals.

College Football Week 5 Opening Odds

Odds as of September 25th at DraftKings Sportsbook.

The biggest favorite of the week is #3 Ohio State by 40.5 points at home over Rutgers. The smallest line is one point in which Duke is favored at home over Virginia.

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NC State vs Clemson Odds & Pick

The #10 North Carolina State Wolfpack (4-0/0-0 ACC) plays its conference opener Saturday and it will be a difficult one as the Wolfpack visits #5 Clemson (4-0, 2-0). The Tigers have opened as seven-point favorites.

Devin Leary threw for 320 yards and four touchdowns, including a 75-yard strike on the first play from scrimmage, and four touchdowns to lead North Carolina State to a 41-10 rout of visiting Connecticut on Saturday.

FIRST OFFENSIVE PLAY OF THE GAME: TD 😤 @PackFootball pic.twitter.com/dLvRoRj9bc

— ACC Network (@accnetwork) September 24, 2022

Leary completed 32 of 44 passes. The touchdowns went to four different receivers, including one to Porter Rooks, who had his first career TD. North Carolina State scored on its first five possessions to build a 31-0 lead.

Leary still isn’t among the top favorites in the Heisman odds, but he could change that with a big game against Clemson.

Nate Wiggins broke up Sam Hartman’s fourth-down pass in the end zone to provide a dramatic ending to Clemson’s 51-45 victory at Wake Forest in double overtime.

When it matters most. Make the play. pic.twitter.com/7qIno3YDoE

— Clemson Football (@ClemsonFB) September 24, 2022

D.J. Uiagalelei threw for 375 yards and five touchdowns to lead Clemson. The last TD was a 25-yard pass to Davis Allen to start the second overtime that proved to be the game-winning score.

This figures to be a great game and Leary gives NC State a legitimate chance to pull a road upset.

Pick: NC State +7 (-110)

Kentucky vs Ole Miss Odds & Pick

Two unbeaten teams square off in the SEC on Saturday when #7 Kentucky (4-0/1-0 SEC) visits #14 Mississippi (4-0/0-0 SEC) in the conference opener for the Rebels. Ole Miss is a 5.5-point choice.

Kentucky had to hold off Northern Illinois 31-21 at home on Saturday as Will Levis threw four touchdown passes.

In sync – @will_levis ➡️ @BarionBrown 70-yard catch-and-run for a TD.#22OnMe x #ForTheTeam 😼🏈 pic.twitter.com/HTSyES6RVt

— Kentucky Football (@UKFootball) September 25, 2022

After the game was tied 14-14 at halftime, Levis put the Wildcats ahead by throwing a 70-yard TD strike to Barion Brown 58 seconds into third quarter. Levis also connected with Tayvion Robinson for a 40-yard score in the second half.

Levis was 18-of-26 passing for 303 yards but was sacked five times.

Quarterback Jaxson Dart and true freshman running back Quinshon Judkins accounted for four touchdowns in the second quarter as Ole Miss rallied for a 35-27 victory over Tulsa on Saturday in Oxford.

Down 14-7, Dart threw 31-yard touchdown passes to Malik Heath and Jonathan Mingo. Judkins then had 1 and 4 scored yards to turn 14-7 deficit into a 35-14 halftime lead.

Dart completed 13 of 24 passes for 154 yards and added 116 yards rushing on 13 carries. The Rebels had 462 yards of total offense, including 140 yards on the ground by Judkins in 27 carries.

That sideline juke giving us @1kalwaysopen_ vibes. 🤩@ogmingo1k | #HottyToddy
🖥 https://t.co/3xOaIvd1CQ pic.twitter.com/eZsz9vVJ2C

— Ole Miss Football (@OleMissFB) September 24, 2022

Ole Miss has played a soft non-conference schedule, to be sure, but Dart and Judkins figure to be tough for Kentucky to handle.

Pick: Ole Miss -5.5 (-110)

That’s Outta Line

The opening line that raises my eyebrows is Arizona being a 17-point favorite at home over Colorado on Saturday in the Pac-12.

Colorado is all kinds of bad as it has been outscored by 126 points while losing its first four games. It is hard to see coach Karl Dorrell even surviving the season.

Arizona is unquestionably on the rise under second-year coach Jedd Fisch. However, the Wildcats (2-2) got burned for 49 points by a pedestrian California team Saturday.

The Wildcats are the better team but don’t seem like they are 17 points better than the Buffaloes.