Arizona Cardinals vs Las Vegas Raiders Odds, Lines & Picks

• The Arizona Cardinals take on the Las Vegas Raiders on Sunday, September 18th
• Derek Carr’s Raiders are priced as 5.5-point favorites in the Week 2 NFL odds
• See the Cardinals vs Raiders picks and odds ahead of Sunday afternoon at 4:25 pm ET

Two teams eager to get into the winner’s circle will square off Sunday, September 18th, as the Arizona Cardinals do battle with the Las Vegas Raiders.

Derek Carr and the Raiders are 5.5-point favorites over Kyler Murray and the Cardinals. The Cards got pasted by the Chiefs 44-21 in Week 1, while the Raiders dropped a close 24-19 contest to their AFC West rival Chargers.

Just forty-five % of bets have been placed against the spread for the Raiders to cover, with 57% of the handle laid on Vegas in Cardinals vs Raiders NFL betting trends, with seventy-four % of the handle being placed on over 51.5 points.

Cardinals vs Raiders Odds

Odds as of September 17. Be sure to check out this unique Barstool Sportsbook promo code to bet on the NFL this weekend.

The Raiders are -235 favorites on the moneyline, 5.5-point favorites on the spread and the total is set at 51.5 in this Cardinals vs Raiders matchup.

However, the Cards are predicted to win 28-17.9 based on our formula.

Kickoff at Allegiant Stadium is set for 4:25 pm ET. Since the Raiders play in a dome, weather won’t be a factor in this one. CBS is carrying the broadcast in the United States.

Cardinals and Raiders Week 1 Performances

The Cardinals Week 1 contest against the Chiefs was a continuation of their floundering ways to end last season. In all, they’ve lost six of their last seven outings. They were outmatched by Patrick Mahomes and company, with KC’s signal caller racking up 360 passing yards and five TD passes. Kyler Murray, meanwhile, was only able to muster less than 200 passing yards.

TE Zach Ertz said QB Kyler Murray is more vocal as a leader compared to last year.

"He went around the locker room postgame (after the Week 1 loss) and told everyone we're going to be alright. He's been building the team up this week and not dwelling on the past."

— KPJ (@KevinParrishJr) September 15, 2022

Derek Carr struggled early in his battle against the Chargers, throwing three interceptions. However, he nearly led his team to an improbable comeback, as they were down by 14 points in the third quarter. Davante Adams debuted as advertised, to the tune of ten catches for 141 yards and a TD, but the Raiders lost by five points. He’s worth a look for your Cardinals vs Raiders props.

Cardinals vs Raiders Injury Report

The Cardinals may still be without the services of J.J. Watt, who missed the first game (calf). However, he did practice Thursday which gives the team hope. Second-year receiver Rondale Moore is out with a hamstring injury, as is fellow wideout Andy Isabella. Cornerback Trayvon Mullen Jr., safety Jalen Thompson and offensive lineman Justin Pugh were all listed as questionable.

For Vegas, center Andre James (concussion), safety Tre’von Moehrig (hip) and linebacker Denzel Perryman (ankle) have been ruled out.

Of course, the Cards won’t have All-Pro wideout DeAndre Hopkins as he’s serving his six-game suspension. Should Arizona fall deep into a hole, Kliff Kingsbury could find himself as the first coach fired.

In my estimation, Kliff Kingsbury still hasn't won a "must win" game at the NFL level.

Sunday at the Raiders is as close to a "must win" game as a Week 2 matchup can be for the Arizona Cardinals and their hopes for a winning season in 2022.

— Alex Clancy (@ClancysCorner) September 16, 2022

In NFL public betting trends, people are on board with Las Vegas. Spread wagering is showing 57% of handle placed on Derek Carr and co. On the moneyline, just 35% of bettors are believing in the Cards, yet 63% of the handle is on them. The over of 51.5 is getting the action on the total. There’s 74% of handle on the over, and 60% of bets.

Cardinals vs Raiders Prediction

It’s only one game, but the Cardinals have to be feeling the intense heat, following their collapse last year, particularly since they play in the ultra tough NFC West. They’re without more key players than Vegas, and Kyler Murray won’t have the services of some of his trusted weapons on offense.

However, despite the Raiders winning four of their last five regular-season games, all of those contests were tight, with five points the highest winning margin.

Derek Carr in his last 12 starts:

5 Wins – 7 Losses
14 TD – 13 INT
11 Fumbles pic.twitter.com/NGPHhPMSFk

— Pinhead Sports® (@_PinheadSports) September 14, 2022

Five of the last six Raiders duels have gone under 51 points. They’re the better team, and are coming in with less injuries. They should be able to take care of Arizona, but expect another close tilt, with them squeaking out a victory, but not covering the 5.5 points in our picks against the spread.

The Pick:

• Cardinals +5.5 (-107); 1.5 units to win 1.90 units
• UNDER 51.5 (-109) 1.5 units to win 1.88 units

2022 record: 1-1; Overall for -0.08 units