New York Giants vs Tennessee Titans, Odds, Lines, and Picks

• The Tennessee Titans host the New York Giants in Week 1
• The Titans were the top seed in the AFC last year, but were bounced in the Divisional Playoff
• See the Giants vs Titans picks and odds ahead of their Week 1 clash, and our pick below

For Ryan Tannehill, it’s a season to shake off the disappointments of playoffs past and prove he can lead the Tennessee Titans to a title.

For Daniel Jones, it’s a season to prove he can be a starting quarterback, whether it’s for the New York Giants or another team in the NFL.

It makes for an interesting cross-conference matchup in Week 1, where the Titans opened as 5.5-point favorites.

The teams will kick things off from Nissan Stadium in the Music City at 4:25 pm ET, in a game that can be seen live on FOX.

Giants vs Titans Odds

Odds as of September 10th from Barstool Sporstbook. Get this Barstool Sportsbook promo code to bet on NFL Week 1

According the Week 1 NFL Betting Trends, 76% of the bets placed are for the Titans to cover the spread, while a whopping 87% of bets are picking Tennessee outright.

The total has shaved by a half point to 43.5, likely due to the fact that rain is forecast during the tilt, with temperatures at 79 degrees and humid at kickoff.

Titans Betting Outlook

The top seed in the AFC a season ago, Tennessee is just +3500 in the 2023 Super Bowl odds.

The good news is that all-world running back Derrick Henry is healthy to start the season. Henry was leading the league in rushing when a foot injury downed him in Week 8, and he didn’t return again until the postseason.

Still, his totals over seven games were legit: his 937 yards rushing ranked ninth and his 10 rushing touchdowns were tied for sixth place.

DERRICK HENRY GOES 60 YARDS FOR THE TD ⚔️

(via @NFLBrasil)pic.twitter.com/eFHutZVJ9j

— ESPN (@espn) September 19, 2021

A healthy Henry will mean the world to Tannehill, who is trying to shake the stink off a Divisional Playoff home loss to the Bengals last year, where he threw for just 220 yards with one TD and three interceptions.

Roster shakeups definitely weakened his offensive weapons, with top receiver AJ Brown dealt to the Eagles in the offseason. Top pick Treylon Burks might not yet be ready for WR1 duties, which means Robert Woods may be the top option, and he’s coming off an ACL injury.

Ryan Tannehill on his trust with his #Titans WRs and the circle getting smaller: pic.twitter.com/axwYN4rv1P

— AtoZ Sports Nashville (@AtoZSports) September 7, 2022

With Henry, though, the play-action attack is so much more lethal, so it might not matter too much on who is running routes.

Defensively, they were just outside the top 10 in total yards, but Mike Vrabel’s crew were stout, holding teams to 20.8 points per game (6th in the NFL). While they were great at stopping the run (84.6 yards per game, 2nd), they were just 25th in pass defense, and lost top edge rusher Harold Landry for the year to an ACL injury in the preseason.

Giants Betting Outlook

How’s this for pressure: even if Jones could get the Giants to the postseason — a place they haven’t been five years and running — even a trip to the NFC Title game might not be enough for New York to bring him back next year. Essentially, he’s showcasing for his free agency this summer.

The Daniel Jones TD throw to John Ross is even better than I remembered in the moment: pic.twitter.com/Iv7XwXH63A

— Zack Rosenblatt (@ZackBlatt) October 5, 2021

Jones played only 11 games last season, winning four, tossing 10 TDs to seven interceptions. The hope is new head coach Brian Daboll can develop him into something better than serviceable, like he did with a raw talent named Josh Allen in Buffalo.

Jones should have a healthier offensive line at least, with potential star power at the tackles in Evan Neal and Andrew Thomas. That should help spring some holes for Saquon Barkley, who has battled a multitude of leg injuries the last three seasons. When healthy, he’s definitely been a home-run hitter.

Most rushes of 50+ yards since 2018:

SAQUON BARKLEY* 9
Nick Chubb 9
Derrick Henry 9

*missed 31 of 65 games during span pic.twitter.com/fmEkuZWEFl

— CBS Sports (@CBSSports) September 8, 2022

Defensively, the Giants were middle-of-the-pack in pass defense, but a woeful 25th in rush defense, surrendering 129 yards per game.

How they handle Henry will be key, but they could be going about it short-handed, particularly at linebacker. Kayvon Thibodeaux (knee), who currently owns the second-best NFL Defensive Rookie of the Year odds and second-year man Azeez Ojulari (Calf) are both doubtful Sunday, leaving Leonard Williams as the only known commodity in the front seven.

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Giants vs Titans Pick

If there’s a time to get goofy with the underdogs, Week 1 would be it. This game should be a prime example, but it’s a hard bridge to cross.

While Tennessee has only covered the spread once in their past six season openers, the Giants want them to hold their beer. The G-Men are 0-5 ATS in their last five Week 1 games, and are 0-6 ATS in their last six games as an underdog.

Even with Tennessee’s less potent offensively than in previous years, there is some continuity of a successful program on both sides of the ball.

And consider they are 25-3 when Henry runs for 100+ yards. With New York’s weakened second level of defense, expect King Henry to get fed early and often, making it a rough opener for the visitors.

The Pick: Titans -5.5 (-110); 1 unit to win 0.91 units