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US Open Men’s Singles Odds & Picks – Medvedev Looks to Defend His Title

Hayley Graham

by Hayley Graham in Tennis

Updated Aug 29, 2022 · 6:15 AM PDT

Daniil Medvedev holding the trophy after winning the 2021 US Open.
Sep 12, 2021; Flushing, NY, USA; Daniil Medvedev of Russia celebrates with the championship trophy after his match against Novak Djokovic of Serbia (not pictured) in the men's singles final on day fourteen of the 2021 U.S. Open tennis tournament at USTA Billie Jean King National Tennis Center. Mandatory Credit: Danielle Parhizkaran-USA TODAY Sports
  • The US Open will begin on Monday, August 29th
  • 2021 Champion Daniil Medvedev is the favorite to win the tournament
  • Continue below for tournament odds, preview, and

The fourth and final Grand Slam of the year will begin on Monday in Flushing Meadows. The tournament will run from August 29th to September 11th and is played at the Billie Jean King National Tennis Centre. Medvedev will be returning to defend his champion, as the favorite to win this year.

The tournament will feature almost all the top players on tour, including Rafael Nadal, Carlos Alcaraz and Stefanos Tsitsipas, to name a few. It’s sure to be an exciting two weeks.

US Open Men’s Singles Odds

Player Odds
[1] Daniil Medvedev +225
[2] Rafael Nadal +400
[3] Carlos Alcaraz +550
[23] Nick Kyrgios +900
[4] Stefanos Tsitsipas +1400
[11] Jannik Sinner +1700
[10] Taylor Fritz +2000
[13] Matteo Berrettini +2500
[6] Felix Auger-Aliassime +2500
[25] Borna Coric +2500
[9] Andrey Rublev +3500
Cameron Norrie +3500
[8] Hubert Hurkacz +4000
[15] Marin Cilic +5000
Pablo Carreno Busta +6500
[5] Casper Ruud +6500
[19] Denis Shapovalov +8000
Sebastian Korda +10000
Brandon Nakashima +15000
[21] Botic Van De Zandschulp +15000

Odds as of August 28th at DraftKings Sportsbook. Use this DraftKings Sportsbook promo code to bet on the US Open.

On the men’s side, Medvedev will be returning to defend his title, as the favorite to win this year with +225 US Open odds.


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Defending Champion

Medvedev is the No. 1 seed, favorite, and defending champion. He drew the first quarter and will open his tournament up against Stefan Kozlov, which should be an easy win.

The 26-year-old defeated Novak Djokovic in the finals last year to win, but he doesn’t have to worry about facing the Serb this year as he will not be competing in the US Open. But he could potentially face Roberto Bautista Agut or Nick Kyrgios as early as the Round of 16.

Following that Round of 16, it will most likely be tough competitor after tough competitor, with the possibility of Felix Auger-Aliassime, Stefanos Tsitsipas and Rafael Nadal.

Is Medvedev the best bet heading into the tournament?

US Open Contenders

With close to all the top players competing over the next two weeks, there are plenty of players to watch. As any other Grand Slam, expect some upsets early on in the tournament.

Aside from the likes of Nadal, Alcaraz, and Tsitsipas, those that are the top players in the tournament, there are a few others worth keeping an eye out on.

Casper Ruud is competing in the second quarter and could make a run as it might be the most forgiving quarter of the draw. The Norwegian has had a pretty great year and could have a deep run in New York.

11th seed Jannick Sinner has always been a part of the conversation, and again, is someone who might be able to make a deep run in the tournament. He’s in the third quarter alongside Alcaraz and Hurkacz.

US Open Men’s Best Bet

Medvedev is playing some of the best tennis of his career and has been doing so consistently. There’s no real to not take him as the best bet at this point.

Of course, the first couple of rounds will be better indicators of who will be able to come out on top, but right now, Medvedev is the one to beat.

Best Bet: Daniil Medvedev (+225)

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