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NFL DFS Week 6 Lineup: DraftKings Picks for Sunday

Daniel Destler

By Daniel Destler in NFL News

Published:


Bryce Young throwing a pass.
Sep 20, 2026; Atlanta, Georgia, USA; Carolina Panthers quarterback Bryce Young (9) looks to pass during the second quarter against the Atlanta Falcons at Mercedes-Benz Stadium. Mandatory Credit: Dale Zanine-Imagn Images

Week 5 of the NFL season is here, and plenty of opportunities remain on the DraftKings Fantasy main slate. This lineup blends high-volume stars, affordable upside plays, and a few lower-priced options to free up salary for the top of the roster.

The lineup comes in at exactly $50,000, leaving no salary on the table. Here are my DraftKings NFL best daily fantasy picks for Sunday’s Week 5 slate.

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NFL DFS Week 6 DraftKings Lineup

PositionPlayerMatchupSalaryFPPGOPRK
QBBryce YoungCAR @ PHI$5,70024.723rd
RBBucky IrvingPIT @ TB$6,20016.521st
RBCam SkatteboNO @ NYG$5,80010.532nd
WRDevaughn Vele BostonBAL @ CLE$5,50013.825th
WRDrake LondonCHI @ ATL$7,00016.420th
WRTetairoa McMillanCAR @ PHI$7,30020.428th
TEOronde Gadsden IILAC @ KC$3,8004.831st
FLEXTyler WarrenTEN @ IND$5,30014.011th
DSTColtsTEN @ IND$3,4002.625th
Total$50,000

Player-by-player breakdown

Bryce Young – QB, $5,700

Young has shown strong fantasy upside through the first four weeks, throwing for at least 287 yards in three straight games. He also threw for 329 yards and two touchdowns against Detroit in Week 4.

At $5,700, Young offers a cost-effective quarterback option. Pairing him with McMillan gives this lineup additional upside if Carolina’s passing game produces against Philadelphia.

Bucky Irving – RB, $6,200

Irving is coming off his best performance of the season, rushing for 165 yards and a touchdown on 21 carries against Dallas in Week 5. He also caught two passes and scored a receiving touchdown.

That workload and big-play ability make Irving an appealing running back option at $6,200. His receiving involvement also gives him another path to fantasy points.

Cam Skattebo – RB, $5,800

Skattebo has been a consistent part of New York’s rushing attack, recording at least 12 carries in each of his first five games. He has also contributed as a receiver, including three catches for 40 yards in Week 3.

The matchup against New Orleans is rated 32nd in the screenshot’s running back matchup rankings. At $5,800, Skattebo offers a reasonable price for a player who can contribute through both rushing and receiving.

Denzel Boston – WR, $5,500

Boston provides a mid-priced receiving option at $5,500. The screenshot lists Baltimore as the opponent and gives him a 13.8 FPPG average, suggesting a useful fantasy scoring baseline.

His value will depend on his target share and red-zone opportunities. Confirm the player’s full name and expected role before publishing, since the screenshot only identifies him as D. Boston.

Drake London – WR, $7,000

London has been one of Atlanta’s most productive receivers, recording 27 catches for 488 yards through five games. He has surpassed 90 receiving yards in each of his last three outings, including a 194-yard performance against Green Bay.

At $7,000, London offers a strong combination of volume and explosive-play potential. His matchup against Chicago is rated 20th in the screenshot, making him a reasonable mid-range receiver to build around.

Tetairoa McMillan – WR, $7,300

McMillan is Young’s key receiving partner in this lineup. Through four games, he has recorded 26 receptions for 385 yards and two touchdowns. In Week 4, he broke out with 14 catches for 192 yards and two touchdowns against Detroit.

The $7,300 salary is substantial, but McMillan’s recent target volume gives him an excellent ceiling. The Panthers stack could pay off if he continues commanding a large share of Young’s passing production.

Oronde Gadsden II – TE, $3,800

Gadsden is the lineup’s salary-saving tight end. He caught five passes for 36 yards against Seattle in Week 4 after recording a touchdown in Week 2.

At $3,800, he leaves room for higher-priced players like London and McMillan. Kansas City is rated 31st in the screenshot’s tight end matchup rankings, although his relatively modest production makes him a value play rather than a high-floor option.

Tyler Warren – FLEX, $5,300

Warren brings a dependable receiving role to the FLEX spot. He has caught at least five passes in each of his last four games, including seven receptions for 83 yards against Pittsburgh in Week 5. He also added a rushing touchdown in that game.

At $5,300, Warren gives this lineup a strong combination of target volume and versatility. Tennessee is rated 11th in the screenshot’s tight end matchup rankings, making him a useful option even with a tougher matchup.

Colts DST – $3,400

Indianapolis is a moderately priced defensive option at $3,400 against Tennessee. The screenshot lists the matchup as 25th in its defensive matchup ranking and gives the Colts a 2.6 FPPG average.

The Colts will need to generate sacks, turnovers or other high-impact defensive plays to return value. This is more of a salary-based selection than a defense to prioritize for a high ceiling.

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Daniel Destler

Danny Destler is a daily fantasy sports (DFS) and sports betting expert. A graduate of Marist University, Dan covers a wide range of sports topics, creating engaging and evergreen content for DFS enthusiasts and casual fans.

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