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San Francisco 49ers vs Seattle Seahawks Odds, Lines, Picks and Predictions for Week 15 Thursday Night Football

Robert Duff

by Robert Duff in NFL Football

Updated Dec 14, 2022 · 11:41 AM PST

San Francisco 49ers vs Seattle Seahawks Odds, Lines, Picks and Predictions for Week 15 Thursday Night Football
Dec 11, 2022; Santa Clara, California, USA; San Francisco 49ers quarterback Brock Purdy (13) looks towards the sideline before running a play against the Tampa Bay Buccaneers in the third quarter at Levi's Stadium. Mandatory Credit: Cary Edmondson-USA TODAY Sports
  • The San Francisco 49ers are 3-point road favorites over the Seattle Seahawks in the Week 15 TNF game
  • Seattle is 12-2 against the spread in the last 14 home games against San Francisco
  • All of the 49ers vs Seahawks odds, lines, picks and predictions for the Week 15 Thursday Night Football game are analyzed in the following story

The San Francisco 49ers (9-4, 8-5 ATS) are coming in hot to face the Seattle Seahawks (7-6, 6-7 ATS). They are 5-0 straight up in the past five games and 5-1 against the spread in the last six games.

Historically, though, the 49ers are as cold as ice when they travel to Seattle to meet the Seahawks.

San Francisco is 2-12 ATS in the last 14 games played at Seattle. The Seahawks are 10-1 SU in their last 11 home games facing the 49ers.

Oddsmakers, though, are expecting San Francisco to be bucking this trend. The 49ers are set as 3-point road favorites over the Seahawks in the NFL Week 15 TNF game.

49ers vs Seahawks Odds

Team Spread Total Moneyline
San Francisco 49ers -3 (-120) O 43.5 (-110) -190
Seattle Seahawks +3 (+100) U 43.5 (-110) +158

Odds as of December 14 at Caesars Sportsbook. See the available Caesars Sportsbook promo code for the NFL here

There’s been no movement in the betting line or over/under on this game since the NFL Week 15 opening lines were released.

Kickoff at Lumen Field is set for 8:15 pm ET on Thursday, December 15. The weather forecast is calling for clear skies, 1 mph wind and a temperature of 43 degrees.

The game is airing exclusively on Amazon Prime as part of a new partnership for Thursday Night Football with Amazon.

49ers vs Seahawks NFL Betting Trends

The people are in alignment with the oddsmakers. They are also backing the 49ers. The NFL public betting trends are strongly supporting San Francisco. In spread betting splits, the 49ers are drawing 74% of handle and 76% of bets. As far as moneyline splits, 72% of handle and 79% bets are also on San Francisco.

The public split on the total is with the over. It is garnering 62% of handle and 65% bets. Five of the last seven 49ers games have gone over. As well, four of the past five Seahawks games hit on the over.

The 49ers are the +800 co-fourth betting choice in the Super Bowl odds. A win in this game would clinch the NFC West title for San Francisco. Bettors can access -2000 odds on the Niners in the NFL Divisional odds. Seattle is second in the odds at +1000.

Things Are Purdy Good For San Francisco

Generally, an NFL team being down to their third-string QB is a recipe for disaster. In his NFL debut, 49ers QB3 Brock Purdy led the club to a 35-7 drubbing of the Tampa Bay Buccaneers and The Goat, Bucs QB Tom Brady.

What can Purdy do for an encore? Well, he could be leading the 49ers to the division title with a victory in this game.

San Francisco kept its offensive gameplan simple against Tampa Bay. The 49ers relied heavily on the run game, riding Christian McCaffrey (14 carries, 119 yards).

Seahawks In A Funk

Is Geno Smith’s Cinderella season turning into a pumpkin? Four of the eight picks thrown by the Seahawks QB have come in the last three games. Seattle is 1-3 SU and 0-4 ATS in the past four games.

San Francisco’s run-first philosophy should also work against a Seattle defense that was carved up for 223 yards on the ground last week by the Carolina Panthers. The 49ers rambled for 189 yards rushing in their first game against Seattle this season. That was prior to acquiring McCaffrey.

Samuel Out For 49ers

Both clubs are showing some key names on the respective injury lists. For the 49ers, WR Deebo Samuel (ankle) and LDT Kevin Givens (knee) are out. Purdy (oblique), McCaffrey (knee), and RDT Aric Armstead (foot) are listed as questionable.

Seahawks RB Kenneth Walker III, the +260 second betting choice in the NFL OROY odds, was out last week with an ankle injury. But he’s given no injury designation for this week. However, on defense, NT Al Woods (Achilles), WLB Bruce Irvin (knee) and SS Ryan Neal (knee) are questionable.

49ers vs Seahawks Prediction

Only three NFL teams are better ATS bets this season than the 49ers. Seattle is 3-3 ATS at home this season.

Seattle needs to win this game. Not only to still be in with a chance to win the NFC West, but to regain a grasp on a Wild Card playoff spot.

Getting points on a home team is always a good thing. And to make it even better, the Seahawks are 2-0 ATS as a home underdog this season.

  • Pick: Seattle Seahawks +3 (-110)
  • TNF record (0-0 ML, 6-7 ATS, 1-0 O/U)

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