Opening Sweet 16 Odds – Spread, Moneyline & Total for All Eight Games

• Several of the 2024 Sweet 16 matchups are set
• Marquette is the biggest favorite (so far), laying 6.5 points against NC State
• See all the 2024 Sweet 16 odds, point spreads, and game totals

The Sweet 16 at the 2024 NCAA Tournament will take place on Thursday, March 28, and Friday, March 29, at four regional sites across the country. Several of the matchups have already been set, and the remaining games will all be decided by the end of Sunday night.

The table below lists the odds for all available games and will be updated as more Sweet 16 matchups are set.

Sweet 16 Odds for 2024 NCAA Tournament

Odds as of March 24 at DraftKings. 

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Illinois Underdogs to Iowa State Despite Lopsided Victories

In the bottom half of the East Region, #3 Illinois takes on #2 Iowa State. Illinois is a strong contender for the mantle of team-of-the-tournament so far. The Illini are 2-0 ATS in lopsided wins over #14 Morehead State (85-69 as 10.5-point favorites) and #10 Duquesne (89-63 also as 10.5-point favorites).

The third-leading scorer in the nation, Terrence Shannon Jr (23.3 PPG) dropped 26 against Morehead State and 30 against the Dukes.

But Brad Underwood’s high-scoring team now has to face the second-best defense in the nation in the form of Iowa State.

After blowing out #15 South Dakota State (82-65) in round one, the Cyclones distanced #7 Washington State in the second half en route to a 67-56 victory.

Iowa State has held ten straight opponents to 65 points or fewer and averages just 61.3 points against, fourth-best in the country while playing at the 202nd-fastest tempo.

Illinois has scored 70 or more in 20 straight games and averages 84.6 PPG (ninth-most) while playing at the 70th-fastest tempo.

The East Region Final Four takes place at TD Garden, Boston, Massachusetts.

Tennessee Slight Favorites Over Creighton

Two teams that survived close calls on Saturday night meet in the Midwest Region when the #3 Creighton Bluejays take on the #2 Tennessee Volunteers at Little Caesars Arena in Detroit, Michigan.

After blowing out #14 Akron in the first round (77-60), Creighton needed double-overtime to finally put away the #11 Oregon Ducks in round two (86-73).

The six-day break will be much needed for the top-heavy Bluejays. Ryan Kalkbrenner, Trey Alexander, and Baylor Scheierman – the team’s three leading scorers both this year and last – all played at least 49 of the 50 available minutes in Saturday’s double-OT thriller over the Ducks. Each member of that trio played at least 38 minutes in the opening-round win over Akron, as well.  And all three have scored at least 15 points in both games to date.

Tennessee’s win over Texas in the second round looked like it was going to be more comfortable. The Volunteers led by 12 with 13 minutes to play and were still up seven with just over two minutes remaining. But the Longhorns trimmed the lead to just one in the final minute (56-55) before Tennessee sealed the 62-58 victory with clutch free throws.

In the first round, Tennessee overwhelmed #15 Saint Peter’s, leading 46-20 at halftime and runnin away with an 83-49 win.