College Football Upset Predictions for Week 2

• Missouri, Boston College and Pittsburgh are live underdogs in CFB Week 2
• The Tigers were bet down from 9.5-point underdogs to +7.5 vs Kansas State
• Read below for betting odds, analysis and upset predictions for college football Week 2

SEC Missouri and ACC Boston College and Pitt are slight road underdogs in College Football Week 2 against teams that they have had success against in the past.

BC limited Virginia Tech to three points in a victory in Chestnut Hill a year ago, and Pitt won the so-called Johnny Majors classic — Majors coached at both places —  by putting up 41 points on Tennessee in Knoxville last season.

Here are my three college football upset predictions for Week 2:

Missouri vs Kansas Odds

All odds via a Barstool Sportsbook promo code on Sept. 8.

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Upset Prediction No. 1: Missouri, SEC Keep Rolling

The premier conference in the country is 14-1 SU and 10-5 ATS after the first two weeks, and this match presents another opportunity for the SEC to assert itself — even if the Tigers have an implied win probability of only 29.9 percent.

Florida, which has the only league underdog so far this season, covered a small spread in its home victory over No. 7 Utah last Saturday to make the league 14-0. LSU was the only loser, falling 24-23 to Florida State when it had a potential game-tying extra point blocked on the final play.

Brady Cook scrambles 20 yards for the tuddy! #Mizzou #CollegeFootball

https://t.co/Kgjc5u72Fj

— The College Experience (@TCEonSGPN) September 2, 2022

Missouri quarterback Brady Cook, whose first start was in the Texas Bowl last season, threw for 201 yards and touchdowns and rushed for 61 yards and another score in the 52-24 victory over Louisiana Tech last week, a game the Tigers led 38-10 after three quarters. A Tigers’ defense remade through the transfer portal had three first-half interceptions.

Kansas State added Nebraska transfer quarterback Adrian Martinez to complement running back Deuce Vaughn this season. While Vaughn had 126 yards and a touchdown in a 34-0 victory over FCS South Dakota in the home opener, Martinez was not the answer at Nebraska. His decision-making is a question mark, as his touchdown to interception ratio (45/30) attests, and he has lost 16 career fumbles. The NCAA record is 21.

Young running backs, you want to know one of the methods to Deuce Vaughn’s success? Hours and hours of film study. Here’s how Vaughn studied for his 39-yard touchdown run against South Dakota:@KStateFB pic.twitter.com/ji2yRm25KK

— D. Scott Fritchen (@DScottFritchen) September 7, 2022

There was plenty of line movement on this game early. Kansas State opened as a 9.5-point favorite, and the early total was 54.5.

• Upset Pick: Missouri ML (+235)

Boston College vs Virginia Tech Odds

Upset Prediction No. 2: BC Regains Its Footing

A veteran Boston College group led by quarterback Phil Jurkovec will take advantage of a Virginia Tech squad that is experiencing the expected growing pains that come with a new coach Brent Fry (a former Hokie GA who was the defensive coordinator at Penn State last year) and a new quarterback, Marshall transfer Grant Wells.

Grant Wells standing TALL in the face of pressure pic.twitter.com/Ng603XJeQ6

— Cam Mellor (@CamMellor) September 2, 2022

The Hokies lost their season opener 20-17 at Old Dominion when the Monarchs scored the winning touchdown with 33 seconds remaining. Wells threw four interceptions, including one that set up the Monarchs’ winning drive, and the Hokies had five turnovers and committed 14 penalties against a team that has one winning record (2016) since joining the FBS in 2014.

Boston College did not exactly spring out of the gate, blowing a 21-12 lead in a 22-21 home loss to Rutgers. Jurkovec, who missed half of 2021 because of an injury, was 23 of 41 with three touchdowns and two picks. All skill position Eagles return this season, although neither team is expected to make much noise in the ACC according to the conference title odds. 

"Phil [Jurkovec] played one game healthy last season" – @BCEagles Head Football Coach @CoachJeffHafley on QB @pjurkovec in 2021.#ACCKickoff

— DT Sports Media (@CallDT) July 20, 2022

Both teams enter ticked off. BC has a better chance to do something about it. BC is 8-4 ATS on the road against the Hokies.

• Upset Pick: Boston College ML (+120)

Tennessee vs Pitt Odds

Upset Prediction No. 3: Pitt Wins QB Battle

New Pitt quarterback Kedon Slovis is no Kenny Pickett, but he reads defenses well, hangs in the pocket and has an accurate arm. Slovis, who worked with Kurt Warner in high school, has not equaled his breakout 2019 freshman season — 3,502 yards passing, 30 touchdowns, nine picks,  71.9 completion percentage — because of injuries the last two seasons.

Senior Pitt QB Kedon Slovis currently leads all of CFB in passing yards per completion with an average of 19.25 🎯 pic.twitter.com/OWbSyeGliY

— NFL Rookie Watch (@NFLRookieWatxh) September 5, 2022

Pitt will move the ball against Josh Heupel’s offensive-minded Vols behind quarterback Hendon Hooker. The Vols mauled Ball State 59-10 in their home opener last week, but the Panthers’ 38-31 victory in the backyard brawl over West Virginia was more impressive.

have a night @henhook2 #GBO 🍊 pic.twitter.com/zoEMXJrUnV

— Tennessee Football (@Vol_Football) September 2, 2022

The Vols’ defense ranked 90th in Division I last season and struggled against the pass. Pitt is 5-2 as a home dog in its last seven, and they have solid value in the CFB odds to pull off the Week 2 upset.

• Upset Pick: Pitt ML (+190)