Opening College Football Week 10 Odds, Spreads & Early Predictions

• Week 10 college football odds are out
• The 2023 Week 10 NCAAF odds include huge matchups, including LSU vs Alabama, Missouri vs Georgia, and Washington vs USC
• See all the NCAAF Week 10 odds, point spreads, and moneylines

With Week 9 in the books, oddsmakers have released early lines for Week 10 of the 2023 college football season. The Week 10 slate includes huge matchups, none bigger than the heavyweight SEC tilt between #13 LSU and #8 Alabama. A six-game win streak has vaulted Alabama back among the top-five national championship favorites, while LSU – looking to become the first two-loss team to ever qualify for the CFP – can bolster its resume with a road win in Tuscaloosa.

The Power 5 portion of the Week 10 schedule starts with a Big 12 battle between TCU and Texas Tech on Thursday, Nov. 2, and concludes with a Saturday nightcap between UCLA and surging Arizona at 10:30 pm ET on Nov. 4.

The table below lists the opening odds for all games involving Power 5 teams in Week 10.

Week 10 College Football Odds

The biggest spread of Week 10 comes from Purdue vs Michigan where the Wolverines are laying 30.5 points. A week after surpassing Georgia as favorite in the national championship odds, Michigan (8-0, 4-3-1 ATS) was pegged back incrementally during its off week as UGA (8-0, 2-5-1 ATS) routed Florida 43-20, though Michigan (+237) remains a slight favorite over Georgia (+266).

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Odds as of October 22, 2023, at FanDuel Sportsbook. 

UGA is a 17.5-point home favorite over Missouri (7-1, 5-3 ATS) in Week 10.  Third-favorite Florida State is laying 21.5 points at Pitt while fourth-favorite Ohio State is a 19-point road favorite at Rutgers.

The marquee matchups of the week are LSU (6-2, 5-3 ATS) vs Alabama (7-1, 5-3 ATS), where the Tide are modest 3.5-point home favorites over Jayden Daniels and company. The Tigers’ quarterback has seen his Heisman odds improve from +3100 to +450 (third-favorite) during LSU’s current three-game win streak.

UCLA vs Arizona Odds & Early Prediction

I said it last week and I will say it again, in slightly different words: don’t sleep on Arizona (4-3, 7-1 ATS). This is a good football team and freshman QB Noah Fifita is the real deal under center. The Wildcats put up their second straight win over a ranked team yesterday, taking down #11 Oregon State 27-24 one week after routing then-#19 Washington State 44-6 on the road. Fifita was 25-of-32 (78.1% passing) for 275 yards and three touchdowns against the Beavers.

Arizona does have three losses on the year, but they were all one-score setbacks to quality teams, and two were on the road: 31-24 at Mississippi State, 31-24 vs Washington, and 43-41 in OT at USC.

https://www.youtube.com/watch?v=-cXbRIfcTvc

UCLA (6-2, 4-4 ATS) isn’t a bad team, but they’re just 2-2 on the road with wins against San Diego State (35-10) and Stanford (42-7) coupled with losses at Utah (14-7) and Oregon State (36-24). I fully expected to see Arizona open as the favorite here and getting them at even money is good value.

UCLA vs Arizona Pick: Arizona Wildcats moneyline (+100)

Notre Dame vs Clemson Odds & Early Prediction

Now just .500 on the season, Clemson (4-4, 2-6 ATS) heads into Week 10 on a two-game losing streak with the latest coming at NC State (24-17) as 9.5-point road favorites. Thanks in large part to a pick-six from QB Cade Klubnik, the Tigers managed to give up 24 points despite only surrendering 204 yards of total offense to NC State. This continued a theme for Clemson this season, which took a heartbreaking 31-24 OT loss to #4 Florida State in Week 4 while outgaining the Noles 429 to 311.

Notre Dame played by far its worst game of the season against Louisville back in Week 6 (a 33-20 loss) and has responded with two dominant wins over then-#10 USC (48-20) and Pitt (58-7). In addition to the Louisville setback, Notre Dame’s road games include a 45-24 rout over the same NC State team that just beat Clemson, and a 21-14 victory at then-#17 Duke. If they hadn’t suffered a last-second loss to Ohio State in late September, the Irish would be considered a second-tier national championship contender (even with the Louisville loss).

I like Notre Dame to win straight-up, but my favorite play on this game is, without question, the under. Clemson’s defense ranks sixth in the nation in yards allowed per game (266.9) while Notre Dame is 11th (279.2). Both are in the top-ten against the pass. While Clemson’s scoring defense is nowhere near the top of the leaderboard (21.0 PPG), their stats have been inflated – in the wrong direction – by three periods of overtime (18 total points in OT) and an uncharacteristic -3 turnover differential.

If the DSTs aren’t scoring points, this game is likely to stay under its total of 46.5.

Notre Dame vs Clemson Picks:

• Under 46.5
• Notre Dame moneyline (-184)