Opening College Football Week 12 Odds, Spreads & Early Predictions

• Most of the Week 12 college football odds have opened
• Only a couple matchups feature two ranked teams
• See all the available opening Week 12 NCAAF odds, below, plus early picks and lines to target

The Week 12 college football odds are starting to trickle in and, though it’s not the best week of matchups, there are a few games on the docket with huge College Football Playoff implications.

The ranked-on-ranked games this week are #18 Utah vs #21 Arizona, #2 Georgia vs #13 Tennessee, #25 Kansas State vs #16 Kansas, and #5 Washington vs #12 Oregon State, those the numbers will change on Tuesday when the next set of CFP rankings are released.

The table below lists the odds for all games involving Power 5 teams in Week 12, plus select Group of 5 games.

Week 12 College Football Odds

With a handful of SEC teams playing G5 competition (LSU, Ole Miss, Auburn), there are some massive point spreads on the board in the Week 12 college football odds. The biggest spread in an all-Power 5 matchup is Oklahoma laying 23 on the road at BYU.

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Odds as of Nov. 12, 2023, on the FanDuel app and the DraftKings Sportsbook app. If you’ve already signed-up at FanDuel and DraftKings, see the latest on the upcoming ESPN Bet promo code.

Michigan (+216) and Georgia (+253) continue to lead the national championship odds heading into Week 12 with Alabama (+633) moving up to third thanks to an eighth straight win. Meanwhile, Oregon’s Bo Nix became an odds-on favorite in the latest Heisman odds, though Washington’s Michael Penix Jr is a close second-favorite.

Louisville vs Miami Odds & Early Prediction

The Louisville Cardinals (9-1, 1-1 away, 5-5 ATS) are an inexplicable road loss to Pittsburgh away from being in the national championship conversation. In Week 12, they travel to Miami (6-4, 5-0 home, 5-5 ATS) to face a Hurricanes team that’s lost its footing.

Miami put up a good fight against #4 Florida State last week but wound up on the wrong end of a 27-20 scoreline and saw QB Emory Williams suffer a season-ending broken arm. Williams was just a week into his tenure as starter after assuming the mantle from Tyler Van Dyke. Now head coach Mario Cristobal has to turn back to his underwhelming junior pivot.

All of that would seem to point to the Cardinals being the play.

But they’re not.

While Miami has lost four of its past six games, all four came on the road. They remain a perfect 5-0 at home, including wins over Clemson and Texas A&M. Louisville, meanwhile, has only played two true road games this year. One was the abomination against Pitt (38-21 loss) and the other was an uninspiring 13-10 win over NC State.

Louisville is a good team, but I’m not convinced their offense will travel to Coral Gables. Miami has a rock-solid defense that just held the Seminoles to 322 yards of total offense.

Miami is the play as a plus-money home underdog.

Louisville vs Miami Pick: Miami moneyline (+110)

Utah vs Arizona Odds & Early Prediction

I have been backing the surging Arizona Wildcats (7-3, 4-1 home, 8-2 ATS) since their two narrow losses to Washington and USC, and they haven’t disappointed. Arizona has reeled off four straight wins, including then-#19 Washington State (44-6 away) and then-#11 Oregon State (27-24 home).

They failed to cover as big road favorites in Colorado last week, but showed championship mettle coming from a touchdown behind in the fourth quarter to win 34-31.  They outgained Colorado by nearly 100 yards (421-339), including 207 to 77 on the ground. In short, the score was closer than it should have been and nothing about that game dissuades me from my opinion that Arizona is a very good football team.

https://www.youtube.com/watch?v=dy-grv3n3iI

There is a lot to like about Utah (7-3, 2-2 away, 6-3-1 ATS), as well, especially on defense. But the Utes are just 2-2 on the road, with one of the victories coming against lowly Baylow by a touchdown (20-13), and the other against a disintegrating USC team by two (34-32). They took a 27-24 lead into halftime last week at unbeaten Washington, but then Bryson Barnes and company failed to score a point in the second half.

The moneyline for this game has yet to be posted, but it’s going to be roughly a pick’em, and I will readily pick Arizona to run its win streak to five.

Utah vs Arizona Pick: Arizona +1 (-110)