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Week 10 College Football Picks Against the Spread

Brady Trettenero

by Brady Trettenero in College Football

Updated Nov 1, 2023 · 6:00 AM PDT

Notre Dame Fighting Irish quarterback Sam Hartman holds the football
Sep 30, 2023; Durham, North Carolina, USA; Notre Dame Fighting Irish quarterback Sam Hartman (10) holds the football before the first half of the game against Duke Blue Devils at Wallace Wade Stadium. Mandatory Credit: Jaylynn Nash-USA TODAY Sports
  • Week 10 of the college football season features a jam-packed slate on Saturday, November 4th
  • Notre Dame hosts Clemson in South Bend, while Florida battles Arkansas
  • Read below for expert Week 10 college football picks against the spread

Week 10 of the college football season features no shortage of pivotal games, and we’ve got CFB against the spreads picks to help you make some money this weekend. We’ve identified three of our top college football ATS picks for the main Saturday slate on November 4th.

Among our Week 10 college football picks against the spread is a play on the Notre Dame Fighting Irish as they travel to South Carolina to face the Clemson Tigers. We also think one side holds all the value in the SEC Arkansas vs Florida SEC showdown.

Let’s get into our expert Week 10 college football picks against the spread.

Notre Dame vs Clemson Odds

Team Spread Moneyline Total
Notre Dame -3 (-112) -155 Over 45 (-108)
Clemson +3 (-108) +130 Under 45 (-112)

 

All odds as of November 1st at DraftKings Sportsbook. Check out the available sportsbook betting apps for college football against the spread wagering. 

Pick #1: Notre Dame (-3) vs Clemson

Kicking off our Week 10 college football picks against the spread is a play on the Notre Dame Fighting Irish as three-point favorites over the Clemson Tigers. The Irish are coming off a bye week to face a Tigers team that has dropped back-to-back games.

UND has been one of the most profitable college football teams against the spread lately, covering the spread in seven of their past 10 games. On the other hand, the Tigers have only covered the number once in their past five contests.

The Irish dominated the Tigers in the trenches when the two teams played last season, rushing for 263 yards in a 35-14 victory. With Sam Hartman now in the fold, the Irish will also be able to air things out in addition to relying on their usually dominant ground game.

The prime reason we are backing the lucky green against the spread, however, is we simply don’t trust this Clemson offense. They are outside the ACC top-five in both passing and rushing, and now face an elite ND defense that is allowing under 300 yards per game and just 15.4 points per contest.

  • Pick: Notre Dame -3 (-112)

Arkansas vs Florida Odds

Team Spread Moneyline Total
Arkansas +6 (-108) +195 Over 50 (-108)
Florida -6 (-112) -238 Under 50 (-112)

Pick #2: Florida (-6) vs Arkansas

Another addition to our Week 10 college football picks against the spread is going to be the Florida Gators as six-point favorites against the Arkansas Razorbacks. Florida is going to be hungry to respond coming off a loss to Georgia, and a win here makes them bowl eligible.

Arkansas’ season has already gone off the rails, and the team is basically playing now to save the job of their head coach Sam Pittman. The Razorbacks fired offensive coordinator Dan Enos, and Kenny Gon, a former backup at Ohio State, will call plays.

Florida has a well-balanced defense that will cause problems for an Arkansas defense that is giving up 333 yards and 23 points per game. Uf’s defense has had similar struggles, but they’ll have an easier time against a lifeless Hogs’ offense that is bottom-three in the SEC in both passing and rushing.

While KJ Jefferson is a talented quarterback capable of going off at any moment, it’s unlikely he will break out of his slump against Florida. The Gators have won 10 of the past 11 meetings, covering in nine of those games. With this game taking place at the ‘Swamp’, we expect Florida to cruise to another double-digit victory.

  • Pick: Florida -6 (-112)

Ohio State vs Rutgers Odds

Team Spread Moneyline Total
Ohio State -19 (-108) -1100 Over 42.5 (-110)
Rutgers +19 (-112) +700 Under 42.5 (-110)

Pick #3: Ohio State -19 (vs Rutgers)

We usually stay away from overly high spreads in our college football picks against the spread, but value is value no matter the number. We have Ohio State projected as a three-touchdown favorite over Rutgers, but the CFB odds list the Buckeyes as only 19-point favorites.

This is a clear mismatch, and we don’t think the Buckeyes will take their foot off the gas as they aim to prove they deserve the top spot in the college football playoff bracket. Take a look at the nine all-time Ohio State vs Rutgers games, and you’ll see the Buckeyes have won each one by at least 20 points.

YouTube video

We don’t think this will be the year the Buckeyes end the trend considering how much they still have to play for this season. Rutgers could be a popular upset pick this weekend when you look a their 6-2 record, but keep in mind they’ve played one of the easiest strengths schedules in FBS and will likely be an underdog in all remaining games.

Buckeyes’ pivot Kyle McCord committed three turnovers last weekend against Wisconsin, and he’ll want to bounce back against Rutgers and get his game back on track with Michigan looming. Considering Rutgers ranks 67th nationally in sacking the QB, look for McCord to have time in the pocket to carve up this Scarlet Knights’ secondary and lead OSU to a statement win.

  • Pick: Ohio State -19 (-108)

 

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