College Football Week 6 Upset Picks

• Week 6 of the college football season features another loaded slate of games on Saturday, Oct. 10th
• The Big 12 and ACC are ripe for upsets this week
• See the odds and best upset picks for Week 6 within our story below

The college football season is in full swing, and Week 6 features another big slate of games. The Big 12 conference has been a roller coaster this year, and there’s a chance for even more craziness this weekend.

In the ACC, there’s one underdog to like on the moneyline.

Here are three upset picks you should consider making for Week 6 of college football.

#22 Texas vs Oklahoma Odds

All odds taken Oct. 7 at DraftKings

Ehlinger Leads Texas to Red River Showdown Victory

Sam Ehlinger and the Longhorns will look to hand unranked Oklahoma a third consecutive loss when the two teams clash in the annual Red River Showdown in Dallas on Saturday. The experience of the Texas QB is a primary reason to consider betting Texas over freshman Spencer Rattler and the Sooners.

Sam Ehlinger's 14 passing touchdowns and 15 total touchdowns are the most ever by a Texas QB in a three-game stretch. pic.twitter.com/7SwLnchI3l

— Texas Football (@TexasFootball) October 6, 2020

This will be the fifth time Ehlinger has faced OU in his career, which is a big advantage going up against an inexperienced QB who has struggled at times in the early goings. Ehlinger has gone off for 1,151 passing yards and five touchdowns, while adding an additional eight scores on the ground in his career against the Sooners.

Both these teams have been messes defensively and are being faded in the National Championship odds, but there’s more to like about Texas and the Longhorns offense. Rattler has thrown four interceptions in his last two games, and will be playing the first big rivalry game of his college career. This could become a shootout, and that’s where the experience of Ehlinger and the Texas offense (nation-leading 51 PPG) gives them the edge. Also look for a big day from junior running back Keaontay Ingram after a costly fumble last time out.

With pressure mounting on Texas coach Tom Herman, he needs a signature rivalry win more than anything. With a loss, Herman could fall to 1-4 all-time against Oklahoma. Trust the leadership of Ehlinger to help his team regroup from the TCU loss and rebound with a big win over the Sooners in Week 6.

Pick: Texas (+108)

Kansas State vs TCU Odds

Wildcats Don’t Need Thompson to Beat Horned Frogs 

One of the reasons Kansas State is such a heavy underdog against TCU in Week 6 is because it’s unclear if starting QB Skylar Thompson will be able to play after injuring his arm in last week’s win over Texas Tech.

Rest assured, Kansas State can still pull off the upset if Skylar can’t go.

Wildcats backup QB Will Howard is a very promising freshman who looked poised in his debut last week. The young pivot passed for 173 yards against Texas Tech after taking over in the second quarter, including making 70-yard and 66-yard touchdown passes.

This should be a close game that Kansas State can win by taking advantage of opportunities. TCU earned their first win of the season over Texas in Week 6 by making big plays, including a key fumble recovery at the goal line in the fourth quarter. But they also were sloppy in the game with 14 penalties and a turnover of their own. This Wildcats team has yet to commit a turnover this season and recorded four takeaways in their big upset victory over Oklahoma.

The Wildcats always put up a good fight and took down TCU as +4.5 underdogs in 2019. Their big weapon on Saturday will be RB Deuce Vaughn, who has rushed for 234 yards in three games this season. The Horned Frogs are struggling mightily against the run in 2020, giving up over 180 yards on the ground per game. Kansas State is playing the better football right now and can win this win one outright.

Pick: Kansas State (+255)

Duke vs Syracuse Odds

The Orange Will Take Down Duke

It may be a tad confusing to see 0-4 Duke listed as the favorites over the Orange at the Carrier Dome on Saturday.  This is a well-rested Syracuse team that is coming off a bye week following an impressive victory over Georgia Tech in Week 4. There’s plenty of reason to think that momentum will carry over into this game.

The Orange got their offense rolling against the Yellow Jackets (37 points) after managing just 16 points in their first two games of the year. Freshman running back Sean Tucker was the standout with 111 rushing yards and two scores. That’s going to be a major asset against a Duke rush defense that is allowing 194 yards on the ground per game, most of all ACC teams.

The Blue Devils are coming off a 38-31 home loss to Virginia Tech, which gave them their worst overall start since 2006. Duke has been done in by turnovers, giving up 34 points to opponents on giveaways and ranking second-last in the conference with a -7 turnover margin. That’s not going to cut it against a Syracuse squad that leads the ACC in turnover margin (+6) and showed their defensive prowess with four interceptions and a fumble recovery last time out.

Syracuse has won two straight games at home and will greatly benefit from the extra week of rest. Take the Orange on the Moneyline.

Pick: Syracuse (+115)